YU27691A - Poboljšanja vezana za leukotrienske antagoniste - Google Patents

Poboljšanja vezana za leukotrienske antagoniste

Info

Publication number
YU27691A
YU27691A YU27691A YU27691A YU27691A YU 27691 A YU27691 A YU 27691A YU 27691 A YU27691 A YU 27691A YU 27691 A YU27691 A YU 27691A YU 27691 A YU27691 A YU 27691A
Authority
YU
Yugoslavia
Prior art keywords
leukotriene
antagonists
bond
alkyl
obtaining
Prior art date
Application number
YU27691A
Other languages
English (en)
Inventor
D.M. Gapinski
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of YU27691A publication Critical patent/YU27691A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/88—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)

Abstract

POBOLJŠANJA VEZANA ZA LEUKOTRIENSKE ANTAGONISTE -TRICIKLIČNI DERIVATI KARBOKSI PROPANSKE KISELINE I POSTUPAK ZA NJIHOVO DOBIJANJE, obezbedjeni su novi triciklični derivati karboksipropanske kiseline formule I ili farmaceutski prihvatljive adicione soli sa bazama, u kojoj je Y -CO-, -C(=NOH), -CHON-, -CH2- ILI -C(=CH2)-; A je veza ili -O-; jedan od R1 i R2 je vodonik i drugi od R1 i R2 -CH2CH2COOH; p ima vrednost 1-16; i Z je -H ili -G-Q gde je G veza, -O-, -S(O)t-, -NH-, -CH=CH-, ili -C = C-, Q je fenil ili fenil supstituisan sa jednim ili dva supstituenta izabrana iz grupe koja sadrži haloge, C1-C3 alkil, C1-C3 alkoksi, acetal, nitro, amino, trifluorometil, hidroksi i -S(O)t-(C1-C3) alkil) i svako t je nezavisno sa vrednošću od O-2, kao i postupak za njihovo dobijanje. Ta jedinjenja su dobri leukotrien B4 antagonisti.
YU27691A 1990-02-16 1991-02-15 Poboljšanja vezana za leukotrienske antagoniste YU27691A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/481,413 US4996230A (en) 1990-02-16 1990-02-16 Leukotriene antagonists

Publications (1)

Publication Number Publication Date
YU27691A true YU27691A (sh) 1994-04-05

Family

ID=23911845

Family Applications (1)

Application Number Title Priority Date Filing Date
YU27691A YU27691A (sh) 1990-02-16 1991-02-15 Poboljšanja vezana za leukotrienske antagoniste

Country Status (20)

Country Link
US (1) US4996230A (sh)
EP (1) EP0442748B1 (sh)
JP (1) JPH04211037A (sh)
KR (1) KR910015558A (sh)
CN (1) CN1028639C (sh)
AR (1) AR247205A1 (sh)
AT (1) ATE116980T1 (sh)
AU (1) AU631482B2 (sh)
CA (1) CA2036523A1 (sh)
DE (1) DE69106545T2 (sh)
FI (1) FI910728A (sh)
HU (1) HU208431B (sh)
IE (1) IE910531A1 (sh)
IL (1) IL97242A0 (sh)
NO (1) NO177097C (sh)
NZ (1) NZ237124A (sh)
PT (1) PT96760A (sh)
RU (1) RU2007401C1 (sh)
YU (1) YU27691A (sh)
ZA (1) ZA911111B (sh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
US5352690A (en) * 1992-07-01 1994-10-04 Eli Lilly And Company 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists
US5942641A (en) * 1993-06-18 1999-08-24 Otsuka Pharmaceutical Co., Ltd. Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent
AU696890B2 (en) * 1994-10-13 1998-09-24 Pfizer Inc. Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4 (LTB4) antagonists
KR100232340B1 (ko) * 1994-10-13 1999-12-01 디. 제이. 우드, 스피겔 알렌 제이 류코트리엔 b4(ltb4) 길항물질로서의 벤조피란 및 벤조-축합된 화합물
US5977077A (en) * 1995-08-28 1999-11-02 Interlab Corporation Xanthone analogs for the treatment of infectious diseases
CN1171400A (zh) * 1996-03-05 1998-01-28 武田药品工业株式会社 呫吨衍生物,其制备和用途
AU4515701A (en) 1999-12-02 2001-06-18 Interlab, Inc. Xanthone analogs for treating infectious diseases and complexation of heme and porphyrins
US20060019269A1 (en) * 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
CN112285355B (zh) * 2020-10-20 2023-01-13 四川大学华西医院 Viridiflorin检测试剂在制备COPD诊断试剂盒中的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7008627A (sh) * 1969-06-25 1970-12-29
US3987088A (en) * 1971-09-08 1976-10-19 Burroughs Wellcome Co. Cyclic carbonyl compounds
FR2278331A1 (fr) * 1974-01-24 1976-02-13 Roussel Uclaf Nouveaux acides carboxyliques et leurs derives, leur application comme medicaments et leur procede de preparation
US4166819A (en) * 1975-09-24 1979-09-04 Abbott Laboratories 4-Aroyl substituted phenoxy methylene-5-tetrazoles
GB1543964A (en) * 1976-04-08 1979-04-11 Ici Ltd Method of antagonising herbicides on soyabean and cotton
FI82832C (fi) * 1982-04-27 1991-04-25 Wellcome Found Foerfarande foer framstaellning av terapeutiskt anvaendbara disubstituerade xanten- och xantonderivat.
SE8400239D0 (sv) * 1984-01-19 1984-01-19 Pharmacia Ab Nya arylettiksyraderivat
US4661607A (en) * 1984-09-21 1987-04-28 Chugai Seiyaku Kabushiki Kaisha Furoxanthone derivatives useful as diuretics
ES2061518T3 (es) * 1986-12-23 1994-12-16 Warner Lambert Co Compuestos que tienen propiedades antitumorales y antibacterianas.
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US5242121A (en) * 1991-08-23 1993-09-07 Roto-Mix Enterprises, Ltd. Bale support and cutter

Also Published As

Publication number Publication date
HU208431B (en) 1993-10-28
PT96760A (pt) 1991-11-29
CN1028639C (zh) 1995-05-31
RU2007401C1 (ru) 1994-02-15
EP0442748A1 (en) 1991-08-21
ZA911111B (en) 1992-10-28
DE69106545T2 (de) 1995-06-01
CA2036523A1 (en) 1991-08-17
IE910531A1 (en) 1991-08-28
KR910015558A (ko) 1991-09-30
DE69106545D1 (de) 1995-02-23
CN1054066A (zh) 1991-08-28
IL97242A0 (en) 1992-05-25
EP0442748B1 (en) 1995-01-11
NZ237124A (en) 1992-04-28
HUT56359A (en) 1991-08-28
NO177097B (no) 1995-04-10
AU631482B2 (en) 1992-11-26
NO910608L (no) 1991-08-19
US4996230A (en) 1991-02-26
NO177097C (no) 1995-07-19
JPH04211037A (ja) 1992-08-03
NO910608D0 (no) 1991-02-15
FI910728A (fi) 1991-08-17
ATE116980T1 (de) 1995-01-15
FI910728A0 (fi) 1991-02-14
AR247205A1 (es) 1994-11-30
AU7110391A (en) 1991-08-22

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