EA199900043A1 - ПРОИЗВОДНЫЕ ПИРИДИЛКАРБАМОИЛИНДОЛИНОВ В КАЧЕСТВЕ АНТАГОНИСТОВ 5-НТ2с-РЕЦЕПТОРОВ - Google Patents

ПРОИЗВОДНЫЕ ПИРИДИЛКАРБАМОИЛИНДОЛИНОВ В КАЧЕСТВЕ АНТАГОНИСТОВ 5-НТ2с-РЕЦЕПТОРОВ

Info

Publication number
EA199900043A1
EA199900043A1 EA199900043A EA199900043A EA199900043A1 EA 199900043 A1 EA199900043 A1 EA 199900043A1 EA 199900043 A EA199900043 A EA 199900043A EA 199900043 A EA199900043 A EA 199900043A EA 199900043 A1 EA199900043 A1 EA 199900043A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyridilkarbamoilindolines
antagonists
derivatives
alkyl
ht2c receptors
Prior art date
Application number
EA199900043A
Other languages
English (en)
Other versions
EA001780B1 (ru
Inventor
Стивен Марк Бромидж
Ян Томсон Форбес
Original Assignee
Смитклайн Бичам Плс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичам Плс filed Critical Смитклайн Бичам Плс
Publication of EA199900043A1 publication Critical patent/EA199900043A1/ru
Publication of EA001780B1 publication Critical patent/EA001780B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к гетероциклическим соединениям формулы (I) или их солям, где Х обозначает СН или N; Rобозначает водород или C-алкил; Rи Rнезависимо обозначают галоген, C-алкил или трифторметил, обладающим фармакологической активностью, способам их получения, композициям, содержащим их, и их применению в лечении расстройств ЦНС, таких как тревожность.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900043A 1996-06-20 1997-06-16 Производные пиридилкарбамоилиндолинов в качестве антагонистов 5-нт-рецепторов EA001780B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9612883.0A GB9612883D0 (en) 1996-06-20 1996-06-20 Novel compounds
PCT/EP1997/003156 WO1997048699A1 (en) 1996-06-20 1997-06-16 Indoline derivatives useful as 5-ht-2c receptor antagonists

Publications (2)

Publication Number Publication Date
EA199900043A1 true EA199900043A1 (ru) 1999-06-24
EA001780B1 EA001780B1 (ru) 2001-08-27

Family

ID=10795575

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900043A EA001780B1 (ru) 1996-06-20 1997-06-16 Производные пиридилкарбамоилиндолинов в качестве антагонистов 5-нт-рецепторов

Country Status (33)

Country Link
US (1) US6369060B1 (ru)
EP (1) EP0912554B1 (ru)
JP (1) JP2000512306A (ru)
KR (1) KR20000022045A (ru)
CN (1) CN1229408A (ru)
AP (2) AP9801410A0 (ru)
AR (1) AR008243A1 (ru)
AT (1) ATE228514T1 (ru)
AU (1) AU718597B2 (ru)
BG (1) BG103089A (ru)
BR (1) BR9709911A (ru)
CA (1) CA2258240A1 (ru)
CO (1) CO4890847A1 (ru)
CZ (1) CZ420598A3 (ru)
DE (1) DE69717449T2 (ru)
DZ (1) DZ2250A1 (ru)
EA (1) EA001780B1 (ru)
ES (1) ES2187783T3 (ru)
GB (1) GB9612883D0 (ru)
HU (1) HUP9903439A3 (ru)
ID (1) ID19433A (ru)
IL (1) IL127417A0 (ru)
MA (1) MA24214A1 (ru)
NO (1) NO985972D0 (ru)
NZ (1) NZ333229A (ru)
OA (1) OA10944A (ru)
PE (1) PE86698A1 (ru)
PL (1) PL330796A1 (ru)
SK (1) SK282706B6 (ru)
TR (1) TR199802661T2 (ru)
TW (1) TW382015B (ru)
WO (1) WO1997048699A1 (ru)
ZA (1) ZA975415B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043650A2 (en) * 1998-02-25 1999-09-02 Smithkline Beecham Plc Process(es) for the preparation of 6-trifluoromethyl-indoline derivatives
GB0019950D0 (en) * 2000-08-12 2000-09-27 Smithkline Beecham Plc Compounds
JP2005535560A (ja) 2001-11-28 2005-11-24 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 治療用の化合物
MXPA04008517A (es) * 2002-03-04 2005-08-19 Pharmacia & Upjohn Co Llc Compuestos terapeuticos.
KR101062376B1 (ko) * 2008-04-10 2011-09-06 한국화학연구원 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물
CN102348798A (zh) 2009-01-16 2012-02-08 麻省理工学院 孤独症谱系障碍的诊断和治疗
EP2651403B1 (en) 2010-12-17 2020-12-02 Glaxo Group Limited Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases
WO2014046544A1 (en) 2012-09-21 2014-03-27 Aapa B.V. Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001333A1 (en) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
AU4704693A (en) 1992-08-20 1994-03-15 Smithkline Beecham Plc Condensed indole derivatives as 5HT-2C and 5HT-2B antagonists
GB9313913D0 (en) * 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
EA000304B1 (ru) * 1995-02-02 1999-04-29 Смитклайн Бичам Плс Производные индола как антагонисты рецептора 5-ht
GB9607219D0 (en) * 1996-04-04 1996-06-12 Smithkline Beecham Plc Novel compounds
GB9615767D0 (en) * 1996-07-26 1996-09-04 Smithkline Beecham Plc Novel treatment

Also Published As

Publication number Publication date
JP2000512306A (ja) 2000-09-19
IL127417A0 (en) 1999-10-28
AP9701037A0 (en) 1997-07-31
GB9612883D0 (en) 1996-08-21
TR199802661T2 (xx) 1999-03-22
AU3260297A (en) 1998-01-07
CO4890847A1 (es) 2000-02-28
DZ2250A1 (fr) 2002-12-18
AR008243A1 (es) 1999-12-29
CZ420598A3 (cs) 1999-06-16
HUP9903439A3 (en) 2002-12-28
NO985972L (no) 1998-12-18
PL330796A1 (en) 1999-06-07
AU718597B2 (en) 2000-04-20
ATE228514T1 (de) 2002-12-15
SK175298A3 (en) 1999-05-07
EP0912554B1 (en) 2002-11-27
BG103089A (en) 1999-09-30
DE69717449T2 (de) 2003-10-02
HUP9903439A2 (en) 2000-07-28
MA24214A1 (fr) 1997-12-31
CN1229408A (zh) 1999-09-22
PE86698A1 (es) 1999-01-28
TW382015B (en) 2000-02-11
OA10944A (en) 2003-02-27
NZ333229A (ru) 2000-01-28
ZA975415B (en) 1998-12-21
US6369060B1 (en) 2002-04-09
WO1997048699A1 (en) 1997-12-24
KR20000022045A (ko) 2000-04-25
AP745A (en) 1999-04-28
EA001780B1 (ru) 2001-08-27
SK282706B6 (sk) 2002-11-06
NO985972D0 (no) 1998-12-18
EP0912554A1 (en) 1999-05-06
ID19433A (id) 1998-07-09
DE69717449D1 (de) 2003-01-09
BR9709911A (pt) 1999-08-10
ES2187783T3 (es) 2003-06-16
CA2258240A1 (en) 1997-12-24
AP9801410A0 (en) 1998-12-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU