EA199800062A1 - Новые гетероциклические соединения для лечения боли и их применение - Google Patents
Новые гетероциклические соединения для лечения боли и их применениеInfo
- Publication number
- EA199800062A1 EA199800062A1 EA199800062A EA199800062A EA199800062A1 EA 199800062 A1 EA199800062 A1 EA 199800062A1 EA 199800062 A EA199800062 A EA 199800062A EA 199800062 A EA199800062 A EA 199800062A EA 199800062 A1 EA199800062 A1 EA 199800062A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- independently
- application
- heterocyclic compounds
- compounds
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 102000003840 Opioid Receptors Human genes 0.000 abstract 1
- 108090000137 Opioid Receptors Proteins 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/08—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/16—Eight-membered rings
- C07D313/20—Eight-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/16—Eight-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Полициклические алкалоиды формулы (I), где Rявляется H, Cалкилом или Cарилом, выборочно замещенными полярными группами; Rи Rявляются, независимо, H, OH, Cалкилом, -C(NH)-NH, положительно заряженной группой или Cаракрилом, выборочно замещенными на NH, OH, Cалкил или галоген; или Rи Rсовместно формируют от 5 до 6-элементное кольцо, выборочно включающее гетероатом; Rявляется H, Cалкилом, OR, SRили N(R), отличающиеся тем, что каждый Rявляется, независимо, H, Cалкилом или галогеном; Х является O, S, SO, N-Rили C-(R), отличающимися тем, что каждый Rявляется, независимо, H, Cалкилом или Cаралкилом, выборочно прерванными одним или более гетероатомом; n является целым числом от 0 до 2; m является целым числом от 0 до 3; с тем условием, что, когда Х является CH, тогда Rне является CH, Rи Rоба не являются H, Rне является OH, m не является 3 и n не является 0. Эти соединения входят в составы средств для лечения боли и допустимы фармацевтически. Соединения этого изобретения действуют как агонисты опиатного рецептора.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9514417.6A GB9514417D0 (en) | 1995-07-14 | 1995-07-14 | Novel heterocyclic compounds for the treatment of pain and use thereof |
| PCT/CA1996/000467 WO1997003978A1 (en) | 1995-07-14 | 1996-07-12 | Novel heterocyclic compounds for the treatment of pain and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA199800062A1 true EA199800062A1 (ru) | 1998-08-27 |
| EA001185B1 EA001185B1 (ru) | 2000-12-25 |
Family
ID=10777657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA199800062A EA001185B1 (ru) | 1995-07-14 | 1996-07-12 | Гетероциклические соединения для обезболивания и их применение |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6054474A (ru) |
| EP (1) | EP0850234B1 (ru) |
| JP (1) | JPH11509211A (ru) |
| CN (1) | CN1196053A (ru) |
| AT (1) | ATE209643T1 (ru) |
| AU (1) | AU708504B2 (ru) |
| BR (1) | BR9609548A (ru) |
| CA (1) | CA2223646A1 (ru) |
| DE (1) | DE69617444T2 (ru) |
| EA (1) | EA001185B1 (ru) |
| ES (1) | ES2167577T3 (ru) |
| FI (1) | FI974609A (ru) |
| GB (1) | GB9514417D0 (ru) |
| HU (1) | HUP9900350A3 (ru) |
| NO (1) | NO980144L (ru) |
| NZ (1) | NZ311612A (ru) |
| WO (1) | WO1997003978A1 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10153345A1 (de) * | 2001-10-29 | 2003-05-08 | Gruenenthal Gmbh | Substituierte 1H-Chinoxalin-2-on-Verbindungen und substituierte 4-Aryl- und 4-Heteroarylcyclohexan-Verbindungen |
| US6881829B2 (en) * | 2002-04-26 | 2005-04-19 | Chimeracom, L.L.C. | Chimeric hybrid analgesics |
| CN108210933B (zh) * | 2016-12-22 | 2021-05-04 | 北京键凯科技股份有限公司 | 一种地佐辛与聚乙二醇的结合物 |
| US20220117913A1 (en) * | 2019-02-02 | 2022-04-21 | Yangtze River Pharmaceutical Group Co., Ltd. | Dezocine derivative and medical use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3836670A (en) * | 1971-11-19 | 1974-09-17 | American Home Prod | Benzobicycloalkane amines for inducing analgesia |
| US5214156A (en) * | 1988-03-25 | 1993-05-25 | The Upjohn Company | Therapeutically useful tetralin derivatives |
| IL93464A (en) * | 1989-02-27 | 1996-10-16 | Lilly Co Eli | 2-Amino-1,2,3,4-Tetrahydronaplanin and 3 aminochromes with a transformed ring, a process for their preparation and pharmaceutical preparations containing them |
-
1995
- 1995-07-14 GB GBGB9514417.6A patent/GB9514417D0/en active Pending
-
1996
- 1996-07-12 ES ES96921855T patent/ES2167577T3/es not_active Expired - Lifetime
- 1996-07-12 EA EA199800062A patent/EA001185B1/ru not_active IP Right Cessation
- 1996-07-12 DE DE69617444T patent/DE69617444T2/de not_active Expired - Fee Related
- 1996-07-12 AU AU62968/96A patent/AU708504B2/en not_active Ceased
- 1996-07-12 EP EP96921855A patent/EP0850234B1/en not_active Expired - Lifetime
- 1996-07-12 NZ NZ311612A patent/NZ311612A/xx unknown
- 1996-07-12 HU HU9900350A patent/HUP9900350A3/hu unknown
- 1996-07-12 WO PCT/CA1996/000467 patent/WO1997003978A1/en active IP Right Grant
- 1996-07-12 CA CA002223646A patent/CA2223646A1/en not_active Abandoned
- 1996-07-12 AT AT96921855T patent/ATE209643T1/de not_active IP Right Cessation
- 1996-07-12 JP JP9506109A patent/JPH11509211A/ja active Pending
- 1996-07-12 US US08/981,932 patent/US6054474A/en not_active Expired - Fee Related
- 1996-07-12 BR BR9609548A patent/BR9609548A/pt unknown
- 1996-07-12 CN CN96196893A patent/CN1196053A/zh active Pending
-
1997
- 1997-12-23 FI FI974609A patent/FI974609A/fi unknown
-
1998
- 1998-01-13 NO NO980144A patent/NO980144L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9514417D0 (en) | 1995-09-13 |
| ATE209643T1 (de) | 2001-12-15 |
| CN1196053A (zh) | 1998-10-14 |
| BR9609548A (pt) | 1999-03-02 |
| NZ311612A (en) | 1999-05-28 |
| HUP9900350A3 (en) | 1999-11-29 |
| EA001185B1 (ru) | 2000-12-25 |
| DE69617444T2 (de) | 2002-08-01 |
| HUP9900350A2 (hu) | 1999-06-28 |
| AU6296896A (en) | 1997-02-18 |
| WO1997003978A1 (en) | 1997-02-06 |
| EP0850234A1 (en) | 1998-07-01 |
| CA2223646A1 (en) | 1997-02-06 |
| DE69617444D1 (de) | 2002-01-10 |
| NO980144D0 (no) | 1998-01-13 |
| JPH11509211A (ja) | 1999-08-17 |
| US6054474A (en) | 2000-04-25 |
| FI974609A (fi) | 1998-01-14 |
| ES2167577T3 (es) | 2002-05-16 |
| AU708504B2 (en) | 1999-08-05 |
| NO980144L (no) | 1998-01-13 |
| FI974609A0 (fi) | 1997-12-23 |
| EP0850234B1 (en) | 2001-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2215746C2 (ru) | Гетероциклические производные глицил-бета-аланина в качестве антагонистов витронектина | |
| NO931151D0 (no) | Fremgangsmaate for fremstilling av nitrogenholdige heterocykliske forbindelser med kondenserte ringer | |
| DK0640592T3 (da) | N-acylerede tricycliske azaheteroringe anvendelige som vasopressin-antagonister | |
| EA200100203A1 (ru) | Производные 4,4-биарилпиперидина с активностью в отношении опиоидных рецепторов | |
| EA200000592A1 (ru) | Азаполициклические соединения, конденсированные с арилом | |
| DK0430190T3 (da) | Hidtil ukendte tricykliske forbindelser | |
| DK0540526T3 (da) | Quinuclidinderivater | |
| BG60262B1 (bg) | Метод за получаване на заместени двупръстенни съединения | |
| EA199700156A1 (ru) | Производные индола как антагонисты рецептора 5-нт | |
| DE69011318D1 (de) | Diazinderivate als Angiotensin II Rezeptor Antagonisten. | |
| NO911121D0 (no) | Fremgangsmaate for fremstilling av nye skvalen-synetase-inhibitorer. | |
| RU94045881A (ru) | Производные пептидов, способ получения, фармацевтическая композиция, способ лечения | |
| EA199901075A1 (ru) | Лечение резистентности к инсулину средствами, стимулирующими секрецию гормона роста | |
| EA199900161A1 (ru) | Производные пиридазино [4,5-в]-хинолин-5-оксида, их получение и применение в качестве антагонистов глицина | |
| FI811373L (fi) | Substituerade fenyletrar | |
| ES2111930T3 (es) | Antagonistas del acido amp y procedimientos de tratamiento con la ayuda de estos. | |
| EA199800062A1 (ru) | Новые гетероциклические соединения для лечения боли и их применение | |
| ES2132245T3 (es) | Derivados de 1-azaadamantano como agonistas o antagonistas de 5-ht. | |
| EA199900043A1 (ru) | ПРОИЗВОДНЫЕ ПИРИДИЛКАРБАМОИЛИНДОЛИНОВ В КАЧЕСТВЕ АНТАГОНИСТОВ 5-НТ2с-РЕЦЕПТОРОВ | |
| PE20011321A1 (es) | Indanilimizadoles policiclicos nuevos con actividad adrenergica alfa 2 | |
| DE69316392D1 (de) | Azanoradamantane | |
| RU98102400A (ru) | Производные полициклических алкалоидов как антагонисты nmda-рецептора | |
| MX9800281A (es) | Compuestos heterociclicos nuevos para el tratamiento de dolores y uso de los mismos. | |
| ATE164519T1 (de) | Verwendung von pyridine derivate zur behandlung der okulären hypertomie | |
| RU94019331A (ru) | Конденсированные трициклические азотсодержащие гетероциклы, фармацевтическая композиция, способ лечения |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |