EA199901075A1 - Лечение резистентности к инсулину средствами, стимулирующими секрецию гормона роста - Google Patents

Лечение резистентности к инсулину средствами, стимулирующими секрецию гормона роста

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Publication number
EA199901075A1
EA199901075A1 EA199901075A EA199901075A EA199901075A1 EA 199901075 A1 EA199901075 A1 EA 199901075A1 EA 199901075 A EA199901075 A EA 199901075A EA 199901075 A EA199901075 A EA 199901075A EA 199901075 A1 EA199901075 A1 EA 199901075A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
growth hormone
secretion
methods
compounds
Prior art date
Application number
EA199901075A
Other languages
English (en)
Other versions
EA002089B1 (ru
Inventor
Филип Алберт Карпайно
Чарлз Куок-Фанг Чью
Брюс Аллен Лефкер
Лидиа Кодетта Пэн
Джудит Ли Тредуэй
Майкл Пол Завистоски
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA199901075A1 publication Critical patent/EA199901075A1/ru
Publication of EA002089B1 publication Critical patent/EA002089B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF] (Somatoliberin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Данное изобретение относится к способам лечения резистентности к инсулину у млекопитающего, при которых указанному млекопитающему вводят эффективное количество соединения формулы Iгде переменные являются такими, как определено в описании, или его стереоизомерных смесей, диастереомерно обогащенных, диастереомерно чистых, энантиомерно обогащенных или энантиомерно чистых изомеров, или фармацевтически приемлемых солей и пролекарств. Соединения формулы (I) являются средствами, стимулирующими секрецию гормона роста, и как таковые могут применяться для увеличения уровня эндогенного гормона роста. В другом аспекте данного изобретения предложены некоторые промежуточные соединения, которые можно использовать в синтезе упомянутых выше соединений, и некоторые способы, используемые для синтеза указанных промежуточных соединений и соединений формулы (I). Кроме того, данное изобретение относится к способам, при которых человеку или другому животному вводят комбинацию функционального антагониста соматостатина, такого как α-2-адренергический агонист, и соединения формулы (I).Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199901075A 1997-06-25 1998-06-05 Способ лечения резистентности к инсулину средствами, стимулирующими секрецию гормона роста EA002089B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5079097P 1997-06-25 1997-06-25
PCT/IB1998/000876 WO1998058949A1 (en) 1997-06-25 1998-06-05 Treatment of insulin resistance with growth hormone secretagogues

Publications (2)

Publication Number Publication Date
EA199901075A1 true EA199901075A1 (ru) 2000-08-28
EA002089B1 EA002089B1 (ru) 2001-12-24

Family

ID=21967444

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199901075A EA002089B1 (ru) 1997-06-25 1998-06-05 Способ лечения резистентности к инсулину средствами, стимулирующими секрецию гормона роста

Country Status (41)

Country Link
US (3) US6448263B1 (ru)
EP (1) EP1000085B1 (ru)
JP (2) JP2000514099A (ru)
KR (1) KR20010014224A (ru)
CN (2) CN1152049C (ru)
AP (1) AP1145A (ru)
AR (1) AR012256A1 (ru)
AT (1) ATE305477T1 (ru)
AU (1) AU747510B2 (ru)
BG (1) BG104008A (ru)
BR (1) BR9810477A (ru)
CA (1) CA2294464A1 (ru)
CO (1) CO4950621A1 (ru)
DE (1) DE69831745T2 (ru)
DZ (1) DZ2539A1 (ru)
EA (1) EA002089B1 (ru)
EG (1) EG21712A (ru)
ES (1) ES2248899T3 (ru)
HK (1) HK1028051A1 (ru)
HN (1) HN1998000088A (ru)
HR (1) HRP980361A2 (ru)
HU (1) HUP0001922A3 (ru)
ID (1) ID24345A (ru)
IL (7) IL154116A0 (ru)
IN (1) IN189724B (ru)
IS (1) IS5275A (ru)
MA (1) MA24581A1 (ru)
NO (1) NO996205L (ru)
NZ (1) NZ500655A (ru)
OA (1) OA11242A (ru)
PA (1) PA8452601A1 (ru)
PE (1) PE105399A1 (ru)
PL (1) PL337659A1 (ru)
SK (1) SK175699A3 (ru)
TN (1) TNSN98113A1 (ru)
TR (1) TR199903257T2 (ru)
TW (1) TW553943B (ru)
UA (1) UA64751C2 (ru)
WO (1) WO1998058949A1 (ru)
YU (1) YU70199A (ru)
ZA (1) ZA985546B (ru)

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UA64751C2 (ru) 1997-06-25 2004-03-15 Пфайзер Продактс Інк. Translated By PlajЛЕЧЕНИЕ ИНСУЛИНОВОЙ ТОЛЕРАНТНОСТИ ВЕЩЕСТВАМИ, КОТОРЫЕ УСИЛИВАЮТ СЕКРЕЦИЮ ГОРМОНА РОСТА
UA53716C2 (ru) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратная соль замещенного дипептида в качестве средства, стимулирующего секрецию гормона роста
US6541634B2 (en) 1999-02-26 2003-04-01 Pfizer Inc. Process for preparing growth hormone secretagogues
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IL145106A0 (en) * 2000-08-30 2002-06-30 Pfizer Prod Inc Intermittent administration of a geowth hormone secretagogue
CA2496687A1 (en) * 2002-09-18 2004-04-01 Centre Hospitalier De L'universite De Montreal (Chum) Ghrh analogues
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US7828934B2 (en) * 2004-12-21 2010-11-09 Hercules Incorporated Reactive cationic resins for use as dry and wet strength agents in sulfite ion-containing papermaking systems
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BRPI0807046A2 (pt) 2007-02-09 2015-05-26 Tranzyme Pharma Inc Composto, composição farmacêutica, métodos de tratar um distúrbio, uma doença cardiovascular e um paciente que sofre de motilidade gastrointestinal reduzida ou disfuncional e, kit.
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Also Published As

Publication number Publication date
WO1998058949A1 (en) 1998-12-30
HUP0001922A2 (hu) 2000-12-28
IL154112A0 (en) 2003-07-31
ATE305477T1 (de) 2005-10-15
IN189724B (ru) 2003-04-19
HRP980361A2 (en) 1999-02-28
EP1000085B1 (en) 2005-09-28
AU7445698A (en) 1999-01-04
CN1530107A (zh) 2004-09-22
US20030100561A1 (en) 2003-05-29
IL156465A (en) 2004-07-25
AP1145A (en) 2003-02-14
KR20010014224A (ko) 2001-02-26
AP9801267A0 (en) 1998-06-30
IL154116A0 (en) 2003-07-31
ZA985546B (en) 2000-01-10
IL133626A0 (en) 2001-04-30
AU747510B2 (en) 2002-05-16
JP2000514099A (ja) 2000-10-24
IS5275A (is) 1999-11-26
IL154115A0 (en) 2003-07-31
BR9810477A (pt) 2007-05-22
SK175699A3 (en) 2001-04-09
BG104008A (en) 2000-07-31
OA11242A (en) 2003-07-23
US6630487B2 (en) 2003-10-07
DZ2539A1 (fr) 2003-02-08
TW553943B (en) 2003-09-21
JP3742643B2 (ja) 2006-02-08
NO996205D0 (no) 1999-12-15
YU70199A (sh) 2003-01-31
HUP0001922A3 (en) 2001-02-28
PA8452601A1 (es) 2000-05-24
CO4950621A1 (es) 2000-09-01
HK1028051A1 (en) 2001-02-02
HN1998000088A (es) 1999-01-08
IL154114A0 (en) 2003-07-31
CN1259140A (zh) 2000-07-05
EA002089B1 (ru) 2001-12-24
IL156465A0 (en) 2004-01-04
US6867202B1 (en) 2005-03-15
ES2248899T3 (es) 2006-03-16
EG21712A (en) 2002-02-27
ID24345A (id) 2000-07-13
CN1152049C (zh) 2004-06-02
NO996205L (no) 1999-12-15
TNSN98113A1 (fr) 2005-03-15
PE105399A1 (es) 1999-11-04
DE69831745T2 (de) 2006-08-31
EP1000085A1 (en) 2000-05-17
IL154111A0 (en) 2003-07-31
TR199903257T2 (xx) 2000-12-21
AR012256A1 (es) 2000-09-27
DE69831745D1 (de) 2006-02-09
PL337659A1 (en) 2000-08-28
UA64751C2 (ru) 2004-03-15
JP2005097261A (ja) 2005-04-14
CA2294464A1 (en) 1998-12-30
NZ500655A (en) 2002-02-01
US6448263B1 (en) 2002-09-10
MA24581A1 (fr) 1998-12-31

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