DE69316392D1 - Azanoradamantane - Google Patents

Azanoradamantane

Info

Publication number
DE69316392D1
DE69316392D1 DE69316392T DE69316392T DE69316392D1 DE 69316392 D1 DE69316392 D1 DE 69316392D1 DE 69316392 T DE69316392 T DE 69316392T DE 69316392 T DE69316392 T DE 69316392T DE 69316392 D1 DE69316392 D1 DE 69316392D1
Authority
DE
Germany
Prior art keywords
carbon atoms
antagonists
alkoxy
hydrogen
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69316392T
Other languages
English (en)
Inventor
Daniel Flynn
Alan Moorman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE69316392D1 publication Critical patent/DE69316392D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69316392T 1992-12-15 1993-11-26 Azanoradamantane Expired - Lifetime DE69316392D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/991,028 US5354757A (en) 1992-12-15 1992-12-15 Azanoradamantanes
PCT/US1993/011347 WO1994013667A1 (en) 1992-12-15 1993-11-26 Azanoradamantanes

Publications (1)

Publication Number Publication Date
DE69316392D1 true DE69316392D1 (de) 1998-02-19

Family

ID=25536774

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69316392T Expired - Lifetime DE69316392D1 (de) 1992-12-15 1993-11-26 Azanoradamantane

Country Status (8)

Country Link
US (2) US5354757A (de)
EP (1) EP0674639B1 (de)
JP (1) JPH08504441A (de)
AT (1) ATE162191T1 (de)
AU (1) AU5674894A (de)
CA (1) CA2151282A1 (de)
DE (1) DE69316392D1 (de)
WO (1) WO1994013667A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530018A (en) * 1994-02-04 1996-06-25 G. D. Searle & Co. Meso-azanoradamantanes
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US6558708B1 (en) * 1995-05-17 2003-05-06 Cedars-Sinai Medical Center Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US20040096423A1 (en) * 2000-11-24 2004-05-20 Megens Antonius Adrianus Hendrikus Petrus Use of a triple combination comprising a 5ht3 antagonist, a 5ht4agonist and a laxative for promoting intestinal lavage
WO2008112205A1 (en) 2007-03-09 2008-09-18 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2514006A1 (fr) * 1981-10-05 1983-04-08 Nativelle Sa Ets Acylamino-4 aza-1 adamantanes, procede pour leur preparation, et application en therapeutique
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
DE3587151T2 (de) * 1984-12-20 1993-07-15 Sandoz Ag Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
GB8523211D0 (en) * 1985-09-19 1985-10-23 Beecham Group Plc Compounds
HU202108B (en) * 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
US4950759A (en) * 1988-07-07 1990-08-21 Duphar International Research B.V. Substituted 1,7-annelated 1H-indazoles
US4992461A (en) * 1989-09-11 1991-02-12 G. D. Searle & Co. N-azabicyclo(3.3.0)octane amides of aromatic acids, compositions, and methods of use thereof
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
US5140023A (en) * 1990-04-27 1992-08-18 G. D. Searle & Co. Azatetracycle compounds
US5137893A (en) * 1991-03-07 1992-08-11 G. D. Searle & Co. Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

Also Published As

Publication number Publication date
US5446049A (en) 1995-08-29
AU5674894A (en) 1994-07-04
ATE162191T1 (de) 1998-01-15
EP0674639B1 (de) 1998-01-14
EP0674639A1 (de) 1995-10-04
US5354757A (en) 1994-10-11
WO1994013667A1 (en) 1994-06-23
JPH08504441A (ja) 1996-05-14
CA2151282A1 (en) 1994-06-23

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Legal Events

Date Code Title Description
8332 No legal effect for de