ES2000524A6 - Procedimiento para la preparacion de nuevas benzamidas y benzoatos sustituidos. - Google Patents

Procedimiento para la preparacion de nuevas benzamidas y benzoatos sustituidos.

Info

Publication number
ES2000524A6
ES2000524A6 ES8600369A ES8600369A ES2000524A6 ES 2000524 A6 ES2000524 A6 ES 2000524A6 ES 8600369 A ES8600369 A ES 8600369A ES 8600369 A ES8600369 A ES 8600369A ES 2000524 A6 ES2000524 A6 ES 2000524A6
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
phenyl
alkoxy
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600369A
Other languages
English (en)
Inventor
Francis David King
Michael Stewart Hadley
Roger Thomas Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES2000524A6 publication Critical patent/ES2000524A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVAS BENZAMIDAS Y BENZOATOS SUSTITUIDOS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (IV) CON UN COMPUESTO DE FORMULA (V) PARA PRODUCIR UN COMPUESTO DE FORMULA (I), EN LAS QUE Q REPRESENTA UN GRUPO SALIENTE, R1 A R7 REPRESENTAN VARIOS RADICALES J, P, Q Y R REPRESENTAN NUMEROS ENTEROS ENTRE 0 Y 3, X ES O, S, SO O NR E Y ES NH U O. LA REACCION SE EFECTUA EN UN DISOLVENTE NO HIDROXILICO O EN UN DISOLVENTE POLAR INERTE FRENTE A LA MISMA, OPCIONALMENTE EN PRESENCIA DE UN CATALIZADOR DESHIDRATANTE O DE UN ACEPTOR DE ACIDO Y A UNA TEMPERATURA ENTRE 10 Y 100JC. POSEEN ACTIVIDAD POTENCIADORA DE LA MOTILIDAD GASTRICA, ACTIVIDAD ANTIEMETICA Y/O ACTIVIDAD ANTAGONICA DEL RECEPTOR DE 5-HT.-
ES8600369A 1985-07-19 1986-07-17 Procedimiento para la preparacion de nuevas benzamidas y benzoatos sustituidos. Expired ES2000524A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858518236A GB8518236D0 (en) 1985-07-19 1985-07-19 Compounds

Publications (1)

Publication Number Publication Date
ES2000524A6 true ES2000524A6 (es) 1988-03-01

Family

ID=10582523

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600369A Expired ES2000524A6 (es) 1985-07-19 1986-07-17 Procedimiento para la preparacion de nuevas benzamidas y benzoatos sustituidos.

Country Status (12)

Country Link
US (2) US4826839A (es)
EP (1) EP0226267B1 (es)
JP (1) JPS6230785A (es)
AU (1) AU594351B2 (es)
DE (1) DE3687515T2 (es)
DK (1) DK340886A (es)
ES (1) ES2000524A6 (es)
GB (1) GB8518236D0 (es)
GR (1) GR861874B (es)
NZ (1) NZ216880A (es)
PT (1) PT83016A (es)
ZA (1) ZA865328B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8615785D0 (en) * 1986-06-27 1986-08-06 Beecham Group Plc Compounds
US4895943A (en) * 1988-10-25 1990-01-23 Pfizer Inc. Preparation of 1,4-diazabicyclo(3.2.2)nonane
US5185333A (en) * 1989-07-03 1993-02-09 Yoshitomi Pharmaceutical Industries, Ltd. Benzazine compounds and pharmaceutical uses thereof
GB9027098D0 (en) * 1990-12-13 1991-02-06 Beecham Group Plc Pharmaceuticals
AU2782792A (en) * 1991-10-15 1993-05-21 Warner-Lambert Company Azabicyclo oxime and amine cholinergic agents and methods of treatment
US5244907A (en) * 1992-03-26 1993-09-14 A. H. Robins Company, Incorporated Carbocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents
US5190953A (en) * 1992-03-26 1993-03-02 A. H. Robins Company, Incorporated Heterocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents
US5679673A (en) * 1992-09-24 1997-10-21 The United States Of America, Represented By The Department Of Health And Human Services Aralkyl bridged diazabicycloalkane derivatives for CNS disorders
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
FR2827288B1 (fr) * 2001-07-12 2003-10-31 Servier Lab Nouveaux derives d'octahydro-2h-pyrido[1,2-a]pyrazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59004A0 (en) * 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
IL61972A0 (en) * 1980-01-30 1981-02-27 Beecham Group Ltd Azabicyclic compounds,their preparation and pharmaceutical compositions containing them
US4352802A (en) * 1980-06-10 1982-10-05 Beecham Group Limited Bicyclo[3.3.1]nonyl-benzamide
ZA832549B (en) * 1982-04-14 1988-09-28 Beecham Group Plc Pharmaceutically active compounds
CA1223873A (en) * 1982-04-14 1987-07-07 Francis D. King Pharmaceutically active compounds

Also Published As

Publication number Publication date
EP0226267A1 (en) 1987-06-24
DE3687515T2 (de) 1993-05-13
AU6027486A (en) 1987-01-22
DE3687515D1 (de) 1993-02-25
NZ216880A (en) 1989-09-27
DK340886D0 (da) 1986-07-17
JPS6230785A (ja) 1987-02-09
EP0226267B1 (en) 1993-01-13
US4826839A (en) 1989-05-02
AU594351B2 (en) 1990-03-08
PT83016A (en) 1986-08-01
US4883874A (en) 1989-11-28
DK340886A (da) 1987-01-20
ZA865328B (en) 1987-06-24
GR861874B (en) 1986-11-10
GB8518236D0 (en) 1985-08-29

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-07-17