ES2167577T3 - Nuevos compuestos heterociclicos para el tratamiento del dolor y utilizacion de los mismos. - Google Patents
Nuevos compuestos heterociclicos para el tratamiento del dolor y utilizacion de los mismos.Info
- Publication number
- ES2167577T3 ES2167577T3 ES96921855T ES96921855T ES2167577T3 ES 2167577 T3 ES2167577 T3 ES 2167577T3 ES 96921855 T ES96921855 T ES 96921855T ES 96921855 T ES96921855 T ES 96921855T ES 2167577 T3 ES2167577 T3 ES 2167577T3
- Authority
- ES
- Spain
- Prior art keywords
- radical
- rent
- independently
- pain
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/08—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/16—Eight-membered rings
- C07D313/20—Eight-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/16—Eight-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
ALCALOIDES POLICICLICOS DE FORMULA (I), DONDE R 1 ES H, UN RADICAL ALQUILO C 1-6 O ARILO C 6-12 SUSTITUIDO OPCIONALMENTE CON GRUPOS POLARES; R 2 Y R 3 SON INDEPENDIENTEMENTE H, OH, UN RADICAL ALQUILO C 1-6 , -C(NH)NH 2 -, UN GRUPO CARGADO POSITIVAMENTE O UN RADICAL ARALQUILO C 7-13 SUSTITUIDO OPCIONALMENTE CON NH 2 , OH, UN RADICAL ALQUILO C 1-6 O UN ATOMO HALOGENO; O R 2 Y R S UB,3 JUNTOS FORMAN UN ANILLO DE 5 A 6 ELEMENTOS QUE OPCIONALMENTE INCORPORA UN HETEROATOMO; R 4 ES H, UN RADICAL ALQUI LO C 1-6 , OR 6 , SR 6 O N(R 6 ) 2 , DONDE CADA R 6 ES INDEPENDIENTEMENTE H, UN RADICAL ALQUILO C SUB,1-3 O UN ATOMO HALOGENO; X ES O, S, SO, SO 2 , NR 5 O C-(R 5 ) 2 , DONDE CADA R 5 ES INDEPENDIENTEMENTE H, UN RADICAL ALQUILO C 1-6 O UN RADICAL ARALQUILO C 7-13 INTERRUMPIDO OPCIONALMENTE CON UNO O MAS HETEROATOMOS; N ES UN NUMERO ENTERO ENTRE 0 Y 2; M ES UN NUMERO ENTERO ENTRE 0 Y 3; CONSIDERANDO SIEMPRE QUE CUANDO X ES CH 2 , R1 NO ES CH 3 , R 2 Y R 3 NO SON NINGUNO H, R 4 NO ES OH, M NO ES 3 Y NNO ES 0. SON UTILES PARA EL TRATAMIENTO DEL DOLOR ASI COMO LAS COMPOSICIONES ACEPTABLES FARMACEUTICAMENTE QUE CONTIENEN ESTOS COMPUESTOS. LOS COMPUESTOS DE ESTA INVENCION ACTUAN COMO AGONISTAS DEL RECEPTOR DE OPIACEOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9514417.6A GB9514417D0 (en) | 1995-07-14 | 1995-07-14 | Novel heterocyclic compounds for the treatment of pain and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2167577T3 true ES2167577T3 (es) | 2002-05-16 |
Family
ID=10777657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96921855T Expired - Lifetime ES2167577T3 (es) | 1995-07-14 | 1996-07-12 | Nuevos compuestos heterociclicos para el tratamiento del dolor y utilizacion de los mismos. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6054474A (es) |
| EP (1) | EP0850234B1 (es) |
| JP (1) | JPH11509211A (es) |
| CN (1) | CN1196053A (es) |
| AT (1) | ATE209643T1 (es) |
| AU (1) | AU708504B2 (es) |
| BR (1) | BR9609548A (es) |
| CA (1) | CA2223646A1 (es) |
| DE (1) | DE69617444T2 (es) |
| EA (1) | EA001185B1 (es) |
| ES (1) | ES2167577T3 (es) |
| FI (1) | FI974609A (es) |
| GB (1) | GB9514417D0 (es) |
| HU (1) | HUP9900350A3 (es) |
| NO (1) | NO980144L (es) |
| NZ (1) | NZ311612A (es) |
| WO (1) | WO1997003978A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10153345A1 (de) * | 2001-10-29 | 2003-05-08 | Gruenenthal Gmbh | Substituierte 1H-Chinoxalin-2-on-Verbindungen und substituierte 4-Aryl- und 4-Heteroarylcyclohexan-Verbindungen |
| US6881829B2 (en) * | 2002-04-26 | 2005-04-19 | Chimeracom, L.L.C. | Chimeric hybrid analgesics |
| CN108210933B (zh) * | 2016-12-22 | 2021-05-04 | 北京键凯科技股份有限公司 | 一种地佐辛与聚乙二醇的结合物 |
| US20220117913A1 (en) * | 2019-02-02 | 2022-04-21 | Yangtze River Pharmaceutical Group Co., Ltd. | Dezocine derivative and medical use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3836670A (en) * | 1971-11-19 | 1974-09-17 | American Home Prod | Benzobicycloalkane amines for inducing analgesia |
| US5214156A (en) * | 1988-03-25 | 1993-05-25 | The Upjohn Company | Therapeutically useful tetralin derivatives |
| ZA901277B (en) * | 1989-02-27 | 1991-10-30 | Lilly Co Eli | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes |
-
1995
- 1995-07-14 GB GBGB9514417.6A patent/GB9514417D0/en active Pending
-
1996
- 1996-07-12 CA CA002223646A patent/CA2223646A1/en not_active Abandoned
- 1996-07-12 ES ES96921855T patent/ES2167577T3/es not_active Expired - Lifetime
- 1996-07-12 EA EA199800062A patent/EA001185B1/ru not_active IP Right Cessation
- 1996-07-12 AU AU62968/96A patent/AU708504B2/en not_active Ceased
- 1996-07-12 WO PCT/CA1996/000467 patent/WO1997003978A1/en active IP Right Grant
- 1996-07-12 BR BR9609548A patent/BR9609548A/pt unknown
- 1996-07-12 US US08/981,932 patent/US6054474A/en not_active Expired - Fee Related
- 1996-07-12 NZ NZ311612A patent/NZ311612A/xx unknown
- 1996-07-12 HU HU9900350A patent/HUP9900350A3/hu unknown
- 1996-07-12 EP EP96921855A patent/EP0850234B1/en not_active Expired - Lifetime
- 1996-07-12 CN CN96196893A patent/CN1196053A/zh active Pending
- 1996-07-12 DE DE69617444T patent/DE69617444T2/de not_active Expired - Fee Related
- 1996-07-12 JP JP9506109A patent/JPH11509211A/ja active Pending
- 1996-07-12 AT AT96921855T patent/ATE209643T1/de not_active IP Right Cessation
-
1997
- 1997-12-23 FI FI974609A patent/FI974609A/fi unknown
-
1998
- 1998-01-13 NO NO980144A patent/NO980144L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997003978A1 (en) | 1997-02-06 |
| FI974609A (fi) | 1998-01-14 |
| JPH11509211A (ja) | 1999-08-17 |
| US6054474A (en) | 2000-04-25 |
| HUP9900350A2 (hu) | 1999-06-28 |
| BR9609548A (pt) | 1999-03-02 |
| AU708504B2 (en) | 1999-08-05 |
| NO980144D0 (no) | 1998-01-13 |
| NO980144L (no) | 1998-01-13 |
| DE69617444D1 (de) | 2002-01-10 |
| EP0850234A1 (en) | 1998-07-01 |
| EP0850234B1 (en) | 2001-11-28 |
| CN1196053A (zh) | 1998-10-14 |
| AU6296896A (en) | 1997-02-18 |
| EA001185B1 (ru) | 2000-12-25 |
| FI974609A0 (fi) | 1997-12-23 |
| EA199800062A1 (ru) | 1998-08-27 |
| NZ311612A (en) | 1999-05-28 |
| DE69617444T2 (de) | 2002-08-01 |
| CA2223646A1 (en) | 1997-02-06 |
| GB9514417D0 (en) | 1995-09-13 |
| ATE209643T1 (de) | 2001-12-15 |
| HUP9900350A3 (en) | 1999-11-29 |
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