ES2064328T3 - Indolilpropanoles, procedimiento para su fabricacion y su uso, asi como preparaciones que contienen los compuestos. - Google Patents
Indolilpropanoles, procedimiento para su fabricacion y su uso, asi como preparaciones que contienen los compuestos.Info
- Publication number
- ES2064328T3 ES2064328T3 ES88109770T ES88109770T ES2064328T3 ES 2064328 T3 ES2064328 T3 ES 2064328T3 ES 88109770 T ES88109770 T ES 88109770T ES 88109770 T ES88109770 T ES 88109770T ES 2064328 T3 ES2064328 T3 ES 2064328T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- indolilpropanoles
- procedure
- manufacture
- well
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
INDOLILPROPANOLES SUSTITUIDOS DE FORMULA (I) EN LA QUE R1 ES UN GRUPO CIANO, CARBOXAMIDA, ALCOXICARBONILO, HIDROXILO O ACETILO; Y ES EL GRUPO (A) DONDE N ES EL NUMERO 2 O 3 O EL GRUPO (B); R2, R3 TIENEN EL SIGNIFICADO DETALLADO EN LA INVENCION. ESTOS COMPUESTOS POSEEN ACCION NIOTROPICA POSITIVA, VASODILATADORA Y ANTIARRITMICA Y SON APROPIADOS PARA EL TRATAMIENTO DE INSUFICIENCIA CORONARIA, ALTERACIONES DEL RITMO CARDIACO E HIPERTONIA, ENFERMEDADES CORONARIAS Y ALTERACIONES DE CIRCULACION ARTERIAL PERIFERICA Y CENTRAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873721260 DE3721260A1 (de) | 1987-06-27 | 1987-06-27 | Neue indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2064328T3 true ES2064328T3 (es) | 1995-02-01 |
Family
ID=6330413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88109770T Expired - Lifetime ES2064328T3 (es) | 1987-06-27 | 1988-06-20 | Indolilpropanoles, procedimiento para su fabricacion y su uso, asi como preparaciones que contienen los compuestos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4935414A (es) |
EP (1) | EP0297380B1 (es) |
JP (1) | JP2577442B2 (es) |
AT (1) | ATE112565T1 (es) |
AU (1) | AU609359B2 (es) |
CA (1) | CA1312078C (es) |
CY (1) | CY1910A (es) |
DE (2) | DE3721260A1 (es) |
ES (1) | ES2064328T3 (es) |
HK (1) | HK87696A (es) |
ZA (1) | ZA884388B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5221674A (en) * | 1989-06-19 | 1993-06-22 | Teikoku Hormone Mfg. Co., Ltd. | Pyridazinone derivatives |
NZ234087A (en) * | 1989-06-19 | 1991-08-27 | Teikoku Hormone Mfg Co Ltd | 2-(3-aryloxy(2-hydroxy-propylamino))-2-methylpropyl- aminophenyl pyridazine derivatives |
DE4002391A1 (de) * | 1990-01-27 | 1991-08-01 | Beiersdorf Ag | Indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
CA2154318A1 (en) * | 1994-08-25 | 1996-02-26 | Richard David Poole | Adaptable radio telephone handset |
US5741789A (en) * | 1995-01-17 | 1998-04-21 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
US5627196A (en) * | 1995-01-17 | 1997-05-06 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
US5789402A (en) * | 1995-01-17 | 1998-08-04 | Eli Lilly Company | Compounds having effects on serotonin-related systems |
US5614523A (en) * | 1995-01-17 | 1997-03-25 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
CA2228938A1 (en) * | 1995-10-03 | 1997-04-10 | Beiersdorf-Lilly Gmbh | Treatment of atherosclerosis |
US5843938A (en) * | 1995-10-03 | 1998-12-01 | Beiersdorf-Lilly Gmbh | Treatment of atherosclerosis |
EP0766962A3 (en) * | 1995-10-03 | 2000-05-10 | Beiersdorf-Lilly GmbH | Treatment of atherosclerosis |
JP2009220797A (ja) * | 2008-03-19 | 2009-10-01 | Tokuo Suzuki | 特に広範囲な視野を持つバックミラー |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4137331A (en) * | 1974-06-19 | 1979-01-30 | Sandoz Ltd. | 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones |
DE2651574A1 (de) * | 1976-11-12 | 1978-05-18 | Boehringer Mannheim Gmbh | Ein neues aminopropanol-derivat und verfahren zu dessen herstellung |
DE2737630A1 (de) * | 1977-08-20 | 1979-03-01 | Boehringer Mannheim Gmbh | Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE2824677A1 (de) * | 1978-06-06 | 1979-12-20 | Hoechst Ag | Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung |
WO1980000152A1 (en) * | 1978-07-03 | 1980-02-07 | Sandoz Ag | 3-aminopropoxy-aryl derivates,preparation and use thereof |
EP0025111B1 (en) * | 1979-08-10 | 1984-07-25 | Sandoz Ag | 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them |
DE3200304A1 (de) * | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
FR2543952B1 (fr) * | 1982-09-03 | 1986-02-21 | Bristol Myers Co | Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique |
GB2163150B (en) * | 1984-07-19 | 1988-05-25 | Sandoz Ltd | 3-aminopropoxyaryl derivatives |
DE3524955A1 (de) * | 1984-07-19 | 1986-01-30 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
GB8502887D0 (en) * | 1985-02-05 | 1985-03-06 | Sandoz Ltd | Pharmaceutical compositions |
-
1987
- 1987-06-27 DE DE19873721260 patent/DE3721260A1/de not_active Ceased
-
1988
- 1988-06-17 US US07/207,997 patent/US4935414A/en not_active Expired - Lifetime
- 1988-06-20 AT AT88109770T patent/ATE112565T1/de not_active IP Right Cessation
- 1988-06-20 DE DE3851720T patent/DE3851720D1/de not_active Expired - Fee Related
- 1988-06-20 EP EP88109770A patent/EP0297380B1/de not_active Expired - Lifetime
- 1988-06-20 ES ES88109770T patent/ES2064328T3/es not_active Expired - Lifetime
- 1988-06-20 ZA ZA884388A patent/ZA884388B/xx unknown
- 1988-06-22 CA CA000570083A patent/CA1312078C/en not_active Expired - Lifetime
- 1988-06-24 AU AU18334/88A patent/AU609359B2/en not_active Ceased
- 1988-06-27 JP JP63159056A patent/JP2577442B2/ja not_active Expired - Fee Related
-
1996
- 1996-05-16 HK HK87696A patent/HK87696A/xx not_active IP Right Cessation
-
1997
- 1997-03-07 CY CY191097A patent/CY1910A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP0297380A3 (en) | 1990-05-09 |
EP0297380B1 (de) | 1994-10-05 |
AU1833488A (en) | 1989-01-05 |
JP2577442B2 (ja) | 1997-01-29 |
DE3851720D1 (de) | 1994-11-10 |
JPS6426558A (en) | 1989-01-27 |
ATE112565T1 (de) | 1994-10-15 |
DE3721260A1 (de) | 1989-01-12 |
HK87696A (en) | 1996-05-24 |
CY1910A (en) | 1997-03-07 |
ZA884388B (en) | 1989-03-29 |
US4935414A (en) | 1990-06-19 |
CA1312078C (en) | 1992-12-29 |
EP0297380A2 (de) | 1989-01-04 |
AU609359B2 (en) | 1991-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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