ES2080764T3 - Derivados de acidos biliares fluorados, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents
Derivados de acidos biliares fluorados, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2080764T3 ES2080764T3 ES90106971T ES90106971T ES2080764T3 ES 2080764 T3 ES2080764 T3 ES 2080764T3 ES 90106971 T ES90106971 T ES 90106971T ES 90106971 T ES90106971 T ES 90106971T ES 2080764 T3 ES2080764 T3 ES 2080764T3
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- fluorated
- procedures
- contain
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 HYDROXYL GROUP Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical group [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
UNOS COMPUESTOS DE FORMULA GENERAL I EN DONDE R1 ES HIDROGENO O HIDROXILO, Y EL GRUPO HIDROXILO DE LA POSICION 7 PUEDE ESTAR EN CONFIGURACION (ALFA) O (BETA), SON VALIDOS EN TERAPIA HUMANA. LOS COMPUESTOS SE PUEDEN PREPARAR POR FLUORACION DE LOS ADECUADOS 6-HIDROXILO-7-KETO DERIVADOS PROTEGIDOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8920170A IT1229570B (it) | 1989-04-17 | 1989-04-17 | Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2080764T3 true ES2080764T3 (es) | 1996-02-16 |
Family
ID=11164384
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90106971T Expired - Lifetime ES2080764T3 (es) | 1989-04-17 | 1990-04-11 | Derivados de acidos biliares fluorados, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5061701A (es) |
EP (1) | EP0393493B1 (es) |
JP (1) | JP3122448B2 (es) |
AT (1) | ATE131173T1 (es) |
CA (1) | CA2014545C (es) |
DE (1) | DE69023947T2 (es) |
DK (1) | DK0393493T3 (es) |
ES (1) | ES2080764T3 (es) |
GR (1) | GR3018387T3 (es) |
IT (1) | IT1229570B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5175320A (en) * | 1989-04-17 | 1992-12-29 | Giuliani S.P.A. | Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
DK0688333T3 (da) * | 1993-03-10 | 1999-02-08 | Magainin Pharma | Steroidderivater, farmaceutiske præparater indeholdende disse og deres anvendelse som antibiotika eller desinfektionsmidler |
US5856535A (en) * | 1994-08-18 | 1999-01-05 | Magainin Pharmaceuticals, Inc. | Aminosterol ester compounds |
US5840740A (en) * | 1995-06-07 | 1998-11-24 | Magainin Pharmaceuticals Inc. | Aminosterol compounds and a method of treating infection using the aminosterol compounds |
US5763430A (en) * | 1995-06-07 | 1998-06-09 | Magainin Pharmaceuticals Inc. | Method of treating a viral infection by administering a steroid compound |
US5994336A (en) * | 1995-06-07 | 1999-11-30 | Magainin Pharmaceuticals Inc. | Method of inhibiting proliferation of cells by administering an aminosterol compound |
US5795885A (en) * | 1995-06-07 | 1998-08-18 | Magainin Pharmaceuticals Inc. | Method of inhibiting profileration of cells by administering an aminosterol compound |
US5847172A (en) * | 1995-06-07 | 1998-12-08 | Magainin Pharmaceuticals Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
US6143738A (en) * | 1995-06-07 | 2000-11-07 | Magainin Pharmaceuticals, Inc. | Therapeutic uses for an aminosterol compound |
US5792635A (en) * | 1995-06-07 | 1998-08-11 | Magainin Pharmaceuticals, Inc. | Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine |
US5874597A (en) * | 1995-06-07 | 1999-02-23 | Magainin Pharmaceuticals, Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
US5840936A (en) * | 1995-06-07 | 1998-11-24 | Magainin Pharmaceuticals Inc. | Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE) |
WO1997040835A1 (en) * | 1996-04-26 | 1997-11-06 | Magainin Pharmaceuticals Inc. | Treatment of carcinomas using squalamine in combination with other anti-cancer agents |
US6596712B2 (en) | 1996-04-26 | 2003-07-22 | Genaera Corporation | Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities |
US6262283B1 (en) | 1996-12-06 | 2001-07-17 | Magainin Pharmaceuticals Inc. | Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds |
PT1274718E (pt) * | 2000-04-12 | 2007-01-31 | Genaera Corp | Processo para a preparação de esteróis 7. alfa-hidroxi 3- aminosubstítuidos utilizando intermediários com um grupo 7. alfa-hidroxilo desprotegido |
DK1392714T3 (da) | 2001-03-12 | 2006-01-09 | Intercept Pharmaceuticals Inc | Steroider som agonister for FXR |
ITMI20021532A1 (it) * | 2002-07-12 | 2004-01-12 | Roberto Pellicciari | Composti chimici |
PL1734970T3 (pl) | 2004-03-12 | 2015-05-29 | Intercept Pharmaceuticals Inc | Leczenie zwłóknienia z zastosowaniem ligandów FXR |
US10987362B2 (en) | 2004-03-12 | 2021-04-27 | Intercept Pharmaceuticals, Inc. | Treatment of fibrosis using FXR ligands |
ITMI20050912A1 (it) * | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
JP5292310B2 (ja) | 2007-01-19 | 2013-09-18 | インターセプト ファーマシューティカルズ, インコーポレイテッド | Tgr5調節剤としての23−置換胆汁酸およびその使用方法 |
EA020310B1 (ru) | 2008-07-30 | 2014-10-30 | Интерсепт Фармасьютикалз, Инк. | Модуляторы рецептора tgr5 и их применение |
ES2458168T3 (es) | 2008-11-19 | 2014-04-30 | Intercept Pharmaceuticals, Inc. | Moduladores de TGR5 y método de uso de los mismos |
CN104781272A (zh) | 2012-06-19 | 2015-07-15 | 英特塞普特医药品公司 | 奥贝胆酸的制备、用途和固体形式 |
US9982008B2 (en) | 2012-06-19 | 2018-05-29 | Intercept Pharmaceuticals, Inc. | Preparation and uses of obeticholic acid |
BR112016002268B1 (pt) | 2013-08-01 | 2022-11-01 | The Penn State Research Foundation | Uso de inibidores do receptor x farnesoide |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4460509A (en) * | 1981-08-19 | 1984-07-17 | Beth Israel Medical Center | Chemical synthesis |
US4545938A (en) * | 1983-11-02 | 1985-10-08 | Beth Israel Medical Center | Chemical synthesis |
US4648995A (en) * | 1983-11-02 | 1987-03-10 | Beth Israel Medical Center | Chemical synthesis |
-
1989
- 1989-04-17 IT IT8920170A patent/IT1229570B/it active
-
1990
- 1990-04-09 US US07/506,837 patent/US5061701A/en not_active Expired - Lifetime
- 1990-04-11 JP JP02096161A patent/JP3122448B2/ja not_active Expired - Fee Related
- 1990-04-11 AT AT90106971T patent/ATE131173T1/de not_active IP Right Cessation
- 1990-04-11 EP EP90106971A patent/EP0393493B1/en not_active Expired - Lifetime
- 1990-04-11 ES ES90106971T patent/ES2080764T3/es not_active Expired - Lifetime
- 1990-04-11 DK DK90106971.6T patent/DK0393493T3/da active
- 1990-04-11 DE DE69023947T patent/DE69023947T2/de not_active Expired - Fee Related
- 1990-04-12 CA CA002014545A patent/CA2014545C/en not_active Expired - Fee Related
-
1995
- 1995-12-13 GR GR950403523T patent/GR3018387T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP3122448B2 (ja) | 2001-01-09 |
JPH02292300A (ja) | 1990-12-03 |
EP0393493A2 (en) | 1990-10-24 |
DK0393493T3 (da) | 1996-04-15 |
CA2014545A1 (en) | 1990-10-17 |
ATE131173T1 (de) | 1995-12-15 |
CA2014545C (en) | 2001-08-14 |
EP0393493A3 (en) | 1992-05-27 |
IT8920170A0 (it) | 1989-04-17 |
DE69023947T2 (de) | 1996-05-30 |
GR3018387T3 (en) | 1996-03-31 |
IT1229570B (it) | 1991-09-04 |
US5061701A (en) | 1991-10-29 |
EP0393493B1 (en) | 1995-12-06 |
DE69023947D1 (de) | 1996-01-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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