AR011957A1 - Derivados de dolastatina 15 con funcionalidades carbonilo y heterociclicas en el c-terminal - Google Patents
Derivados de dolastatina 15 con funcionalidades carbonilo y heterociclicas en el c-terminalInfo
- Publication number
- AR011957A1 AR011957A1 ARP980101061A ARP980101061A AR011957A1 AR 011957 A1 AR011957 A1 AR 011957A1 AR P980101061 A ARP980101061 A AR P980101061A AR P980101061 A ARP980101061 A AR P980101061A AR 011957 A1 AR011957 A1 AR 011957A1
- Authority
- AR
- Argentina
- Prior art keywords
- dolastatin
- cyclical
- hetero
- functionalities
- carbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invencion se relaciona con nuevos péptidos que son de utilidad como agentes anticancerígenos. Los compuestos de la invencion presentan laformula (I): A - B - D - E - F - G, donde A, B, D y E son residuos de de alfa-aminoácidos.En una realizacion, F es un residuo del ácidoazacicloalcancarboxílico. En esta realizacion, G es un radical monovalente, por ejemlo, un átomo de hidrogeno, un grupo alquilo, un grupo arilo o un grupoheteroarilo. en otra realizacion, F es un grupo azacicloalquilo y G es un grupo heteroarilo conectado a F mediante un enlace carbono-carbono. En otrarealizacion, la invencion incluye un método para tratar el cáncer en un mamífero, como un ser humano, que comprende la administraciona dichomamífero de una cantidad efectiva de un compuesto de formula (I) en una composicion aceptable para uso farmacéutico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/814,577 US5965537A (en) | 1997-03-10 | 1997-03-10 | Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011957A1 true AR011957A1 (es) | 2000-09-13 |
Family
ID=25215470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101061A AR011957A1 (es) | 1997-03-10 | 1998-03-10 | Derivados de dolastatina 15 con funcionalidades carbonilo y heterociclicas en el c-terminal |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5965537A (es) |
| EP (1) | EP0981539A1 (es) |
| JP (1) | JP2001518084A (es) |
| KR (1) | KR20000076099A (es) |
| CN (1) | CN1252806A (es) |
| AR (1) | AR011957A1 (es) |
| AU (1) | AU744511B2 (es) |
| BR (1) | BR9808017A (es) |
| CA (1) | CA2297164A1 (es) |
| CO (1) | CO4950525A1 (es) |
| HR (1) | HRP980124A2 (es) |
| HU (1) | HUP0001758A3 (es) |
| IL (1) | IL131596A0 (es) |
| NO (1) | NO994364L (es) |
| TW (1) | TW505657B (es) |
| WO (1) | WO1998040400A1 (es) |
| ZA (1) | ZA981957B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2385528C (en) | 1999-10-01 | 2013-12-10 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| CN100400040C (zh) * | 2000-10-30 | 2008-07-09 | 詹森药业有限公司 | 三肽酶抑制剂 |
| US7256257B2 (en) * | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US6884869B2 (en) * | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| AU2003263964C1 (en) * | 2002-07-31 | 2010-08-19 | Seagen Inc. | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
| DE10240818A1 (de) * | 2002-08-30 | 2004-05-13 | Grünenthal GmbH | Substituierte 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazol-Derivate |
| FR2856685B1 (fr) * | 2003-06-25 | 2005-09-23 | Merck Sante Sas | Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| ES2579836T3 (es) | 2003-11-06 | 2016-08-17 | Seattle Genetics, Inc. | Compuestos de monometilvalina capaces de conjugación con ligandos |
| EP1883627B1 (en) | 2005-05-18 | 2018-04-18 | Pharmascience Inc. | Bir domain binding compounds |
| JP5419685B2 (ja) | 2006-05-16 | 2014-02-19 | ファーマサイエンス・インコーポレイテッド | Ｉａｐｂｉｒドメイン結合タンパク質 |
| CN101802012B (zh) | 2007-07-16 | 2014-08-06 | 健泰科生物技术公司 | 抗cd79b抗体和免疫偶联物及使用方法 |
| US9173961B2 (en) | 2010-02-10 | 2015-11-03 | Immunogen, Inc. | CD20 antibodies and uses thereof |
| WO2011098904A1 (en) | 2010-02-12 | 2011-08-18 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
| CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| CA2938919C (en) | 2014-02-28 | 2020-12-29 | Hangzhou Dac Biotech Co., Ltd | Charged linkers and their uses for conjugation |
| WO2016086357A1 (en) * | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Methyl oxazole orexin receptor antagonists |
| US9987255B2 (en) | 2014-12-19 | 2018-06-05 | Merck Sharp & Dohme Corp. | 5,5-bicyclic oxazole orexin receptor antagonists |
| CN104952808A (zh) * | 2015-06-12 | 2015-09-30 | 广州先艺电子科技有限公司 | 一种预置金锡盖板及其制造方法 |
| JP6759326B2 (ja) | 2015-07-12 | 2020-09-23 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． | 細胞結合分子の共役のための架橋連結体 |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| WO2018086139A1 (en) | 2016-11-14 | 2018-05-17 | Hangzhou Dac Biotech Co., Ltd | Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers |
| CN109776342A (zh) * | 2019-02-26 | 2019-05-21 | 北京大学深圳研究生院 | 顺式β-氨基酸及其衍生物的合成方法 |
| EP4045491A1 (en) * | 2019-10-17 | 2022-08-24 | Givaudan SA | Substituted azacyles as trmp8 modulators |
| JPWO2023033129A1 (es) | 2021-09-03 | 2023-03-09 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816444A (en) * | 1987-07-10 | 1989-03-28 | Arizona Board Of Regents, Arizona State University | Cell growth inhibitory substance |
| US4879278A (en) * | 1989-05-16 | 1989-11-07 | Arizona Board Of Regents | Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15 |
| US5091368A (en) * | 1990-08-08 | 1992-02-25 | Harbor Branch Oceanographic Institution, Inc. | Biologically active compounds from blue-green algae |
| ATE215962T1 (de) * | 1991-08-09 | 2002-04-15 | Teikoku Hormone Mfg Co Ltd | Tetrapeptide derivat |
| RU2116312C1 (ru) * | 1992-05-20 | 1998-07-27 | Басф Акциенгезельшафт | Производные пептида или их соли, фармацевтическая композиция |
| US5831002A (en) * | 1992-05-20 | 1998-11-03 | Basf Aktiengesellschaft | Antitumor peptides |
| CZ286752B6 (en) * | 1992-12-16 | 2000-06-14 | Basf Ag | Peptide and pharmaceutical preparation containing thereof |
| US5504191A (en) * | 1994-08-01 | 1996-04-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide methyl esters |
| US5530097A (en) * | 1994-08-01 | 1996-06-25 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory peptide amides |
| US5554725A (en) * | 1994-09-14 | 1996-09-10 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Synthesis of dolastatin 15 |
| US5807984A (en) * | 1995-11-09 | 1998-09-15 | Basf Aktienegesellschaft | Oligopeptides, the preparation and use thereof |
-
1997
- 1997-03-10 US US08/814,577 patent/US5965537A/en not_active Expired - Fee Related
-
1998
- 1998-03-05 BR BR9808017-2A patent/BR9808017A/pt not_active IP Right Cessation
- 1998-03-05 CA CA002297164A patent/CA2297164A1/en not_active Abandoned
- 1998-03-05 AU AU64482/98A patent/AU744511B2/en not_active Ceased
- 1998-03-05 CN CN98803903A patent/CN1252806A/zh active Pending
- 1998-03-05 WO PCT/US1998/004317 patent/WO1998040400A1/en not_active Application Discontinuation
- 1998-03-05 EP EP98910182A patent/EP0981539A1/en not_active Withdrawn
- 1998-03-05 KR KR1019997008187A patent/KR20000076099A/ko not_active Application Discontinuation
- 1998-03-05 JP JP53963098A patent/JP2001518084A/ja active Pending
- 1998-03-05 HU HU0001758A patent/HUP0001758A3/hu unknown
- 1998-03-05 IL IL13159698A patent/IL131596A0/xx unknown
- 1998-03-09 CO CO98012757A patent/CO4950525A1/es unknown
- 1998-03-09 ZA ZA9801957A patent/ZA981957B/xx unknown
- 1998-03-10 AR ARP980101061A patent/AR011957A1/es unknown
- 1998-03-10 HR HR08/814,577A patent/HRP980124A2/hr not_active Application Discontinuation
- 1998-03-10 TW TW087103515A patent/TW505657B/zh active
-
1999
- 1999-09-09 NO NO994364A patent/NO994364L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0001758A3 (en) | 2001-12-28 |
| WO1998040400A1 (en) | 1998-09-17 |
| AU744511B2 (en) | 2002-02-28 |
| AU6448298A (en) | 1998-09-29 |
| CA2297164A1 (en) | 1998-09-17 |
| US5965537A (en) | 1999-10-12 |
| CO4950525A1 (es) | 2000-09-01 |
| EP0981539A1 (en) | 2000-03-01 |
| BR9808017A (pt) | 2000-03-08 |
| CN1252806A (zh) | 2000-05-10 |
| HUP0001758A2 (hu) | 2001-05-28 |
| TW505657B (en) | 2002-10-11 |
| NO994364D0 (no) | 1999-09-09 |
| KR20000076099A (ko) | 2000-12-26 |
| JP2001518084A (ja) | 2001-10-09 |
| ZA981957B (en) | 1999-09-09 |
| IL131596A0 (en) | 2001-01-28 |
| HRP980124A2 (en) | 1998-12-31 |
| NO994364L (no) | 1999-11-09 |
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