ZA981957B - Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus. - Google Patents

Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus.

Info

Publication number
ZA981957B
ZA981957B ZA9801957A ZA981957A ZA981957B ZA 981957 B ZA981957 B ZA 981957B ZA 9801957 A ZA9801957 A ZA 9801957A ZA 981957 A ZA981957 A ZA 981957A ZA 981957 B ZA981957 B ZA 981957B
Authority
ZA
South Africa
Prior art keywords
dolastatin
terminus
carbonyl
derivatives
functionalities
Prior art date
Application number
ZA9801957A
Other languages
English (en)
Inventor
Kurt Ritter
Wilhelm Amberg
Teresa Barlozzari
Andreas Haupt
Bernd Janssen
Andreas Kling
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of ZA981957B publication Critical patent/ZA981957B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA9801957A 1997-03-10 1998-03-09 Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus. ZA981957B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/814,577 US5965537A (en) 1997-03-10 1997-03-10 Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus

Publications (1)

Publication Number Publication Date
ZA981957B true ZA981957B (en) 1999-09-09

Family

ID=25215470

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9801957A ZA981957B (en) 1997-03-10 1998-03-09 Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus.

Country Status (17)

Country Link
US (1) US5965537A (xx)
EP (1) EP0981539A1 (xx)
JP (1) JP2001518084A (xx)
KR (1) KR20000076099A (xx)
CN (1) CN1252806A (xx)
AR (1) AR011957A1 (xx)
AU (1) AU744511B2 (xx)
BR (1) BR9808017A (xx)
CA (1) CA2297164A1 (xx)
CO (1) CO4950525A1 (xx)
HR (1) HRP980124A2 (xx)
HU (1) HUP0001758A3 (xx)
IL (1) IL131596A0 (xx)
NO (1) NO994364L (xx)
TW (1) TW505657B (xx)
WO (1) WO1998040400A1 (xx)
ZA (1) ZA981957B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CN101307046B (zh) 2000-10-30 2012-08-15 詹森药业有限公司 三肽酶抑制剂
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
PT1545613E (pt) * 2002-07-31 2011-09-27 Seattle Genetics Inc Conjugados de auristatina e sua utilização para tratamento do cancro, de uma doença autoimune ou de uma doença infecciosa
DE10240818A1 (de) * 2002-08-30 2004-05-13 Grünenthal GmbH Substituierte 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazol-Derivate
FR2856685B1 (fr) * 2003-06-25 2005-09-23 Merck Sante Sas Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
SG10201701737XA (en) 2003-11-06 2017-04-27 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
EP2024362A4 (en) 2006-05-16 2012-01-25 Pharmascience Inc IAP BIR DOMAIN BINDING COMPOUNDS
SG183023A1 (en) 2007-07-16 2012-08-30 Genentech Inc Anti-cd79b antibodies and immunoconjugates and methods of use
MX341687B (es) 2010-02-10 2016-08-30 Immunogen Inc "anticuerpos cd20 y su utilización".
US9284350B2 (en) 2010-02-12 2016-03-15 Pharmascience Inc. IAP BIR domain binding compounds
CA2891280C (en) 2012-11-24 2018-03-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
PT3122757T (pt) 2014-02-28 2023-11-03 Hangzhou Dac Biotech Co Ltd Ligantes carregados e as suas utilizações em conjugação
WO2016086357A1 (en) * 2014-12-02 2016-06-09 Merck Sharp & Dohme Corp. Methyl oxazole orexin receptor antagonists
US9987255B2 (en) 2014-12-19 2018-06-05 Merck Sharp & Dohme Corp. 5,5-bicyclic oxazole orexin receptor antagonists
CN104952808A (zh) * 2015-06-12 2015-09-30 广州先艺电子科技有限公司 一种预置金锡盖板及其制造方法
EP3319936A4 (en) 2015-07-12 2019-02-06 Suzhou M-conj Biotech Co., Ltd. PLACES OF CONDUCT FOR THE CONJUGATION OF CELL BINDING MOLECULES
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
JP7138350B2 (ja) 2016-11-14 2022-09-16 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． 共役連結体、該連結体を含有する細胞結合分子－薬物共役体、並びに該共役体及び連結体の使用及び製造方法
CN109776342A (zh) * 2019-02-26 2019-05-21 北京大学深圳研究生院 顺式β-氨基酸及其衍生物的合成方法
US20240132487A1 (en) * 2019-10-17 2024-04-25 Givaudan Sa Substituted azacyles as trmp8 modulators
JPWO2023033129A1 (xx) 2021-09-03 2023-03-09

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
US5091368A (en) * 1990-08-08 1992-02-25 Harbor Branch Oceanographic Institution, Inc. Biologically active compounds from blue-green algae
EP0598129B1 (en) * 1991-08-09 2000-03-22 Teikoku Hormone Mfg. Co., Ltd. Novel tetrapeptide derivative
CZ292612B6 (cs) * 1992-05-20 2003-11-12 Abbott Gmbh & Co. Kg Peptid s protirakovinnou aktivitou, jeho použití a farmaceutický prostředek s obsahem takového peptidu
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
AU679479B2 (en) * 1992-12-16 1997-07-03 Basf Aktiengesellschaft Dolostatin analog
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof

Also Published As

Publication number Publication date
TW505657B (en) 2002-10-11
BR9808017A (pt) 2000-03-08
NO994364D0 (no) 1999-09-09
AU744511B2 (en) 2002-02-28
AU6448298A (en) 1998-09-29
HRP980124A2 (en) 1998-12-31
HUP0001758A2 (hu) 2001-05-28
CN1252806A (zh) 2000-05-10
CA2297164A1 (en) 1998-09-17
NO994364L (no) 1999-11-09
AR011957A1 (es) 2000-09-13
HUP0001758A3 (en) 2001-12-28
IL131596A0 (en) 2001-01-28
JP2001518084A (ja) 2001-10-09
US5965537A (en) 1999-10-12
CO4950525A1 (es) 2000-09-01
WO1998040400A1 (en) 1998-09-17
KR20000076099A (ko) 2000-12-26
EP0981539A1 (en) 2000-03-01

Similar Documents

Publication Publication Date Title
ZA981957B (en) Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus.
ZA977901B (en) Heterocyclic esters and amides.
ZA986358B (en) Dolastatin 15 derivatives.
EP1032377A4 (en) SUBSTITUTED 2-AMINOACETAMIDES AND APPLICATION THEREOF
HK1018780A1 (en) 6-Phenylpyridine-2-ylamine derivatives, the composition and use thereof.
HUP0103560A3 (en) Dolastatin 15 derivatives
ZA964646B (en) Substituted N-(indole-2-Carbonyl)-ß-alanimamides and derivatives as antidiabetic agents.
ZA98533B (en) Soluble CTLA4 mutant molecules and uses thereof.
ZA976222B (en) N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their use.
AU6636598A (en) Novel 3,4-dialkoxyphenyl derivatives and the use thereof
ZA973959B (en) Bellows-type cover with integrated clamping member.
ZA99800B (en) Benzothiadiazoles and derivatives.
IL143095A0 (en) 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives
AU7263300A (en) Opaminergic neuronal survival-promoting factors and uses thereof
ZA979068B (en) Modified electrode material and its use.
CA95352S (en) Cereal piece and the like
HK1026015A1 (en) Supporting device and the holding-profile therefor.
ZA976304B (en) Seal for bags and the like.
AU4318799A (en) Caspase-9 deficient animals and the use thereof
Smith Ways and Means
Sheikh Meantime
GB2392159B (en) Endo-ß-1, 4, xylanase and uses thereof
EP1383530A4 (en) LAMININ 5, 13 AND 14 AND THEIR APPLICATIONS
ZA977300B (en) Anti-atherosclerotic and anti-thrombotic agent and the use thereof.
SI0991658T1 (sl) Derivati dolastatina 15