IL131596A0 - Dolastatin-15 derivatives with carbonyl and heterocyclic functionalities at the c-terminus - Google Patents

Dolastatin-15 derivatives with carbonyl and heterocyclic functionalities at the c-terminus

Info

Publication number
IL131596A0
IL131596A0 IL13159698A IL13159698A IL131596A0 IL 131596 A0 IL131596 A0 IL 131596A0 IL 13159698 A IL13159698 A IL 13159698A IL 13159698 A IL13159698 A IL 13159698A IL 131596 A0 IL131596 A0 IL 131596A0
Authority
IL
Israel
Prior art keywords
dolastatin
terminus
carbonyl
derivatives
functionalities
Prior art date
Application number
IL13159698A
Other languages
English (en)
Original Assignee
Basf Ag
Basf Biores Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Basf Biores Corp filed Critical Basf Ag
Publication of IL131596A0 publication Critical patent/IL131596A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL13159698A 1997-03-10 1998-03-05 Dolastatin-15 derivatives with carbonyl and heterocyclic functionalities at the c-terminus IL131596A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/814,577 US5965537A (en) 1997-03-10 1997-03-10 Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
PCT/US1998/004317 WO1998040400A1 (en) 1997-03-10 1998-03-05 Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the c-terminus

Publications (1)

Publication Number Publication Date
IL131596A0 true IL131596A0 (en) 2001-01-28

Family

ID=25215470

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13159698A IL131596A0 (en) 1997-03-10 1998-03-05 Dolastatin-15 derivatives with carbonyl and heterocyclic functionalities at the c-terminus

Country Status (17)

Country Link
US (1) US5965537A (es)
EP (1) EP0981539A1 (es)
JP (1) JP2001518084A (es)
KR (1) KR20000076099A (es)
CN (1) CN1252806A (es)
AR (1) AR011957A1 (es)
AU (1) AU744511B2 (es)
BR (1) BR9808017A (es)
CA (1) CA2297164A1 (es)
CO (1) CO4950525A1 (es)
HR (1) HRP980124A2 (es)
HU (1) HUP0001758A3 (es)
IL (1) IL131596A0 (es)
NO (1) NO994364L (es)
TW (1) TW505657B (es)
WO (1) WO1998040400A1 (es)
ZA (1) ZA981957B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
HU230376B1 (hu) 2000-10-30 2016-03-29 Janssen Pharmaceutica N.V Tripeptidil peptidáz inhibitorok
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
DK2357006T3 (en) * 2002-07-31 2015-12-21 Seattle Genetics Inc Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
DE10240818A1 (de) * 2002-08-30 2004-05-13 Grünenthal GmbH Substituierte 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazol-Derivate
FR2856685B1 (fr) * 2003-06-25 2005-09-23 Merck Sante Sas Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
CN1938046B (zh) 2003-11-06 2014-03-19 西雅图基因公司 能够与配体偶联的单甲基缬氨酸化合物
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
ATE543835T1 (de) 2007-07-16 2012-02-15 Genentech Inc Anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren
MX341687B (es) 2010-02-10 2016-08-30 Immunogen Inc "anticuerpos cd20 y su utilización".
SG182724A1 (en) 2010-02-12 2012-08-30 Pharmascience Inc Iap bir domain binding compounds
ES2701076T3 (es) 2012-11-24 2019-02-20 Hangzhou Dac Biotech Co Ltd Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
WO2015127685A1 (en) 2014-02-28 2015-09-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
WO2016086357A1 (en) * 2014-12-02 2016-06-09 Merck Sharp & Dohme Corp. Methyl oxazole orexin receptor antagonists
US9987255B2 (en) 2014-12-19 2018-06-05 Merck Sharp & Dohme Corp. 5,5-bicyclic oxazole orexin receptor antagonists
CN104952808A (zh) * 2015-06-12 2015-09-30 广州先艺电子科技有限公司 一种预置金锡盖板及其制造方法
CN113350518A (zh) 2015-07-12 2021-09-07 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CN116143678A (zh) 2016-11-14 2023-05-23 杭州多禧生物科技有限公司 偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用
CN109776342A (zh) * 2019-02-26 2019-05-21 北京大学深圳研究生院 顺式β-氨基酸及其衍生物的合成方法
US20240132487A1 (en) * 2019-10-17 2024-04-25 Givaudan Sa Substituted azacyles as trmp8 modulators
CA3230737A1 (en) 2021-09-03 2023-03-09 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
US5091368A (en) * 1990-08-08 1992-02-25 Harbor Branch Oceanographic Institution, Inc. Biologically active compounds from blue-green algae
DE69230824T2 (de) * 1991-08-09 2000-07-27 Teikoku Hormone Mfg Co Ltd Neue tetrapeptidderivate
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
JP3523253B2 (ja) * 1992-05-20 2004-04-26 アボット ゲーエムベーハー ウント カンパニー カーゲー ドラスタチン誘導体
PL178766B1 (pl) * 1992-12-16 2000-06-30 Basf Ag Nowe peptydy
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof

Also Published As

Publication number Publication date
CN1252806A (zh) 2000-05-10
US5965537A (en) 1999-10-12
CO4950525A1 (es) 2000-09-01
EP0981539A1 (en) 2000-03-01
CA2297164A1 (en) 1998-09-17
NO994364D0 (no) 1999-09-09
ZA981957B (en) 1999-09-09
HUP0001758A3 (en) 2001-12-28
HRP980124A2 (en) 1998-12-31
WO1998040400A1 (en) 1998-09-17
BR9808017A (pt) 2000-03-08
AU6448298A (en) 1998-09-29
TW505657B (en) 2002-10-11
AR011957A1 (es) 2000-09-13
NO994364L (no) 1999-11-09
KR20000076099A (ko) 2000-12-26
HUP0001758A2 (hu) 2001-05-28
JP2001518084A (ja) 2001-10-09
AU744511B2 (en) 2002-02-28

Similar Documents

Publication Publication Date Title
IL131596A0 (en) Dolastatin-15 derivatives with carbonyl and heterocyclic functionalities at the c-terminus
HU9903361D0 (en) Filter-device with collecting-vessel and with heating-device
ZA977901B (en) Heterocyclic esters and amides.
HUP9904335A3 (en) Arylpiperidinol and arylpiperidine derivatives and drugs containing the same
HUP0004885A3 (en) Harvester with withrower and tearing mechanizm
ZA986358B (en) Dolastatin 15 derivatives.
TW399609U (en) Container assembly and container unit
AU5617900A (en) Chimeric chemokine-antigen polypeptides and uses therefor
HUP0000719A3 (en) Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same
GB9919689D0 (en) Back-lighting arrangement and the like
EP1123920A4 (en) HYDRAZINO-OXOACETAMIDE DERIVATIVES AND INSECTICIDES
GB2339329B (en) Magnetoresistive sensor with improved stability
HUP0001603A3 (en) Cycloalkylalkanecarboxamides and the production and use thereof
AU2841801A (en) Triazolotriazinones and the use thereof
GB9824735D0 (en) Injector and injector assembly
GB0023323D0 (en) Arylhydantoin derivatives and uses thereof
EP1194147A4 (en) DERIVATIVES OF ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE
IL127518A0 (en) Substituted heterocyclic benzocycloalkenes and the use thereof as substances having an analgesic effect
HK1036273A1 (en) Pyridine derivative and pharmaceutical containing the same
AU7263300A (en) Opaminergic neuronal survival-promoting factors and uses thereof
HK1041403A1 (zh) 藥劑注入器
IL147534A0 (en) The il-il1 gene and polypeptide products
MXPA02005070A (es) 1-benzazepinas sustituidas y derivados de las mismas.
ZA986273B (en) Purine derivatives and the use for medicine thereof.
GB9917165D0 (en) Polypeptides polynuclcotides and uses thereof