GR3018387T3 - Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them. - Google Patents

Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them.

Info

Publication number
GR3018387T3
GR3018387T3 GR950403523T GR950403523T GR3018387T3 GR 3018387 T3 GR3018387 T3 GR 3018387T3 GR 950403523 T GR950403523 T GR 950403523T GR 950403523 T GR950403523 T GR 950403523T GR 3018387 T3 GR3018387 T3 GR 3018387T3
Authority
GR
Greece
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
acid derivatives
Prior art date
Application number
GR950403523T
Other languages
English (en)
Inventor
Roberto Pellicciari
Aldo Roda
Giuliano Frigerio
Original Assignee
Giuliani Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Giuliani Spa filed Critical Giuliani Spa
Publication of GR3018387T3 publication Critical patent/GR3018387T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
GR950403523T 1989-04-17 1995-12-13 Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them. GR3018387T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8920170A IT1229570B (it) 1989-04-17 1989-04-17 Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.

Publications (1)

Publication Number Publication Date
GR3018387T3 true GR3018387T3 (en) 1996-03-31

Family

ID=11164384

Family Applications (1)

Application Number Title Priority Date Filing Date
GR950403523T GR3018387T3 (en) 1989-04-17 1995-12-13 Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them.

Country Status (10)

Country Link
US (1) US5061701A (el)
EP (1) EP0393493B1 (el)
JP (1) JP3122448B2 (el)
AT (1) ATE131173T1 (el)
CA (1) CA2014545C (el)
DE (1) DE69023947T2 (el)
DK (1) DK0393493T3 (el)
ES (1) ES2080764T3 (el)
GR (1) GR3018387T3 (el)
IT (1) IT1229570B (el)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175320A (en) * 1989-04-17 1992-12-29 Giuliani S.P.A. Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
JP3546886B2 (ja) * 1993-03-10 2004-07-28 ジェネーラ コーポレーション ステロイド誘導体、それらを含む薬剤組成物、及び抗生物質又は消毒薬としてのそれらの使用
US5856535A (en) * 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
US5840740A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
US5763430A (en) * 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
US5874597A (en) * 1995-06-07 1999-02-23 Magainin Pharmaceuticals, Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5795885A (en) * 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
US5840936A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US6143738A (en) * 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
US6596712B2 (en) 1996-04-26 2003-07-22 Genaera Corporation Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
JP2000510460A (ja) * 1996-04-26 2000-08-15 マゲイニン・ファーマシューティカルズ・インコーポレーテッド スクアラミンを他の抗癌剤と併用する上皮性悪性腫瘍の治療
US6262283B1 (en) 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
AU5342701A (en) * 2000-04-12 2001-10-30 Genaera Corp A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group
DK1392714T3 (da) 2001-03-12 2006-01-09 Intercept Pharmaceuticals Inc Steroider som agonister for FXR
ITMI20021532A1 (it) * 2002-07-12 2004-01-12 Roberto Pellicciari Composti chimici
US10987362B2 (en) 2004-03-12 2021-04-27 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using FXR ligands
EP2712617B2 (en) 2004-03-12 2020-11-18 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using Fxr ligands
ITMI20050912A1 (it) * 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
JP5292310B2 (ja) * 2007-01-19 2013-09-18 インターセプト ファーマシューティカルズ， インコーポレイテッド Ｔｇｒ５調節剤としての２３−置換胆汁酸およびその使用方法
CN105037476B (zh) 2008-07-30 2018-06-12 英特塞普特医药品公司 Tgr5调节剂及其使用方法
HUE039171T2 (hu) 2008-11-19 2018-12-28 Intercept Pharmaceuticals Inc TGR5 modulátorok és azok alkalmazási eljárása
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
CA3028207A1 (en) 2012-06-19 2013-12-27 Intercept Pharmaceuticals, Inc. Preparation, uses and solid forms of obeticholic acid
CN105593237B (zh) 2013-08-01 2019-06-04 美国卫生和人力服务部 法尼醇x受体的抑制剂和在医学中的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460509A (en) * 1981-08-19 1984-07-17 Beth Israel Medical Center Chemical synthesis
US4545938A (en) * 1983-11-02 1985-10-08 Beth Israel Medical Center Chemical synthesis
US4648995A (en) * 1983-11-02 1987-03-10 Beth Israel Medical Center Chemical synthesis

Also Published As

Publication number Publication date
DE69023947D1 (de) 1996-01-18
JPH02292300A (ja) 1990-12-03
EP0393493A2 (en) 1990-10-24
EP0393493A3 (en) 1992-05-27
CA2014545C (en) 2001-08-14
US5061701A (en) 1991-10-29
ATE131173T1 (de) 1995-12-15
DE69023947T2 (de) 1996-05-30
EP0393493B1 (en) 1995-12-06
ES2080764T3 (es) 1996-02-16
DK0393493T3 (da) 1996-04-15
IT8920170A0 (it) 1989-04-17
CA2014545A1 (en) 1990-10-17
JP3122448B2 (ja) 2001-01-09
IT1229570B (it) 1991-09-04

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