ES2059335T3 - Derivados de pirido(3,2,1-ij)-1,3,4-benzoxadiazina, procedimiento para su obtencion, preparados farmaceuticos correspondientes y productos intermedios utilizables en el procedimiento. - Google Patents

Derivados de pirido(3,2,1-ij)-1,3,4-benzoxadiazina, procedimiento para su obtencion, preparados farmaceuticos correspondientes y productos intermedios utilizables en el procedimiento.

Info

Publication number
ES2059335T3
ES2059335T3 ES87112990T ES87112990T ES2059335T3 ES 2059335 T3 ES2059335 T3 ES 2059335T3 ES 87112990 T ES87112990 T ES 87112990T ES 87112990 T ES87112990 T ES 87112990T ES 2059335 T3 ES2059335 T3 ES 2059335T3
Authority
ES
Spain
Prior art keywords
procedure
obtaining
pharmaceutical preparations
benzoxadiazina
pirido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87112990T
Other languages
English (en)
Inventor
Masahiro Aoki
Miyako Kamata
Tatsuo Ohtsuka
Nobuo Shimma
Kazuteru Yokose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2059335T3 publication Critical patent/ES2059335T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS TRICICLICOS DE FORMULA GENERAL (I), EN LA QUE R1 ES UN ATOMO DE HIDROGENO O UN GRUPO DE PROTECCION CARBOXI, R2 ES UN ATOMO DE HIDROGENO O UN RESTO ALQUILO INFERIOR SUSTITUIDO SI ES NECESARIO POR UN ATOMO DE HALOGENO, R3 Y R4 SON, INDEPENDIENTEMENTE UNO DE OTRO UN ATOMO DE HIDROGENO O UN RESTO ALQUILO INFERIOR SUSTITUIDO POR UN GRUPO HIDROXI O UN GRUPO AMINO; X ES UN ATOMO DE HALOGENO; R5 Y R6 SON, INDEPENDIENTEMENTE UNO DE OTRO, UN ATOMO DE HIDROGENO O UN RESTO ALQUILO SUSTITUIDO SI ES CASO POR UN GRUPO HIDROXI, UN RESTO ALCOXI INFERIOR O UN GRUPO AMINO R5, R6 Y R7 TIENEN EL SIGNIFICADO DADO EN LA INVENCION. PROCEDIMIENTO PARA SU OBTENCION Y PREPARADOS FARMACEUTICOS QUE LOS CONTIENEN. LOS PRODUCTOS FINALES PRESENTAN ACTIVIDAD ANTIBACTERIANA.
ES87112990T 1986-09-12 1987-09-04 Derivados de pirido(3,2,1-ij)-1,3,4-benzoxadiazina, procedimiento para su obtencion, preparados farmaceuticos correspondientes y productos intermedios utilizables en el procedimiento. Expired - Lifetime ES2059335T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP86112619 1986-09-12
EP87111507 1987-08-08

Publications (1)

Publication Number Publication Date
ES2059335T3 true ES2059335T3 (es) 1994-11-16

Family

ID=26102516

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87112990T Expired - Lifetime ES2059335T3 (es) 1986-09-12 1987-09-04 Derivados de pirido(3,2,1-ij)-1,3,4-benzoxadiazina, procedimiento para su obtencion, preparados farmaceuticos correspondientes y productos intermedios utilizables en el procedimiento.

Country Status (4)

Country Link
US (1) US4801584A (es)
EP (1) EP0259804B1 (es)
DE (1) DE3788177D1 (es)
ES (1) ES2059335T3 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2012681A1 (en) * 1989-03-31 1990-09-30 Masayasu Okuhira Quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same
DE3918544A1 (de) * 1989-06-07 1990-12-13 Bayer Ag Verfahren zur herstellung von 7-(3-amino- sowie 3-amino-methyl-1-pyrrolidinyl)-3-chinolon- carbonsaeuren sowie -naphthyridoncarbonsaeuren
US4992449A (en) * 1990-02-01 1991-02-12 American Cyanamid Company 7-(substituted)cycloalkylamino-1-(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
KR920004385A (ko) * 1990-08-09 1992-03-27 와꾸나가 기스께 신규 삼환화합물 또는 그의 염, 이의 제조방법 및 이를 함유하는 항균제
US5399553A (en) * 1990-08-09 1995-03-21 Wakunaga Seiyaku Kabushiki Kaisha Tricyclic compound or salts thereof, method for producing the same and anti-microbial agent containing the same
EP0530368A4 (en) * 1991-02-28 1994-08-24 Fujisawa Pharmaceutical Co Process for producing tricyclic compound or salt thereof
KR950014567B1 (ko) * 1991-08-01 1995-12-08 주식회사대웅제약 신규한 퀴놀론 카르복실산 유도체
US5221676A (en) * 1992-02-06 1993-06-22 Warner-Lambert Company 7-substituted quinolones and naphthyridones as antibacterial agents
DK0680482T3 (da) * 1993-01-23 1997-05-05 Pfizer Fremgangsmåde til fremstilling af en tricyclisk forbindelse
DE4329600A1 (de) * 1993-09-02 1995-03-09 Bayer Ag Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
DE4416622A1 (de) * 1994-05-11 1995-11-16 Bayer Ag 8-Amino-10-(azabicycloalkyl)-pyrido[1,2,3-d.e] [1,3,4]benzoxa-diazinderivate
DE4416620A1 (de) * 1994-05-11 1995-11-16 Bayer Ag 8-Amino-pyrido[1,2,3-d,e][1,3,4]benzoxadiazinderivate
GB9600886D0 (en) * 1996-01-17 1996-03-20 Pfizer Novel compound
GB9600894D0 (en) * 1996-01-17 1996-03-20 Pfizer Novel compound
GB9600888D0 (en) * 1996-01-17 1996-03-20 Pfizer Method of treatment
GB9601356D0 (en) * 1996-01-24 1996-03-27 Pfizer Novel compound
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
US7977327B2 (en) * 2004-05-13 2011-07-12 Daiichi Sankyo Company, Limited Substituted pyrrolidine derivative
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
FR2896416B1 (fr) 2006-01-24 2010-08-13 Vetoquinol Composition anti-infectieuse comprenant un compose de type pyrido (3,2,1-ij)-benzoxadiazine
FR2928150A1 (fr) 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
EP2145891A1 (en) 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
EP2332916A3 (en) 2009-11-19 2011-08-03 Krka Tovarna Zdravil, D.D., Novo Mesto A process for a preparation of marbofloxacin and intermediate thereof
CN102060860B (zh) * 2011-01-07 2013-04-10 宁波美诺华药业股份有限公司 一种马波沙星的制备方法
CN102617595A (zh) * 2012-03-23 2012-08-01 江西华士药业有限公司 氟喹诺酮类抗菌药马波沙星的制备方法
CN105198905A (zh) * 2015-10-14 2015-12-30 海门慧聚药业有限公司 一种纯化制备超纯马波沙星的方法
CN107383058B (zh) * 2017-08-28 2019-07-26 海门慧聚药业有限公司 马波沙星的制备
DE102017218114A1 (de) * 2017-10-11 2019-04-11 Leuphana Universität Lüneburg Stiftung Öffentlichen Rechts Biologisch abbaubare Chinolon-Antibiotika

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
US4499091A (en) * 1982-03-31 1985-02-12 Sterling Drug Inc. 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents
PH22140A (en) * 1982-06-29 1988-06-01 Daiichi Seiyaku Co Tricyclic compounds
DE3409922A1 (de) * 1984-03-17 1985-09-26 Bayer Ag, 5090 Leverkusen 1,7-diamino-1,4-dihydro-4-oxo-3-(aza)chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung bakterieller erkrankungen
EP0160284B1 (en) * 1984-04-26 1990-10-24 Abbott Laboratories Quino-benoxazine antibacterial compounds
DE3426486A1 (de) * 1984-07-18 1986-01-30 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von chinolon- und naphthyridoncarbonsaeuren
JPS6219865A (ja) * 1985-07-18 1987-01-28 Canon Inc 電子写真感光体

Also Published As

Publication number Publication date
US4801584A (en) 1989-01-31
EP0259804A3 (en) 1989-08-09
DE3788177D1 (de) 1993-12-23
EP0259804A2 (de) 1988-03-16
EP0259804B1 (de) 1993-11-18

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