CN107383058B - 马波沙星的制备 - Google Patents
马波沙星的制备 Download PDFInfo
- Publication number
- CN107383058B CN107383058B CN201710749919.4A CN201710749919A CN107383058B CN 107383058 B CN107383058 B CN 107383058B CN 201710749919 A CN201710749919 A CN 201710749919A CN 107383058 B CN107383058 B CN 107383058B
- Authority
- CN
- China
- Prior art keywords
- formula
- reaction
- marbofloxacin
- preparation
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710749919.4A CN107383058B (zh) | 2017-08-28 | 2017-08-28 | 马波沙星的制备 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710749919.4A CN107383058B (zh) | 2017-08-28 | 2017-08-28 | 马波沙星的制备 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107383058A CN107383058A (zh) | 2017-11-24 |
CN107383058B true CN107383058B (zh) | 2019-07-26 |
Family
ID=60345636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710749919.4A Active CN107383058B (zh) | 2017-08-28 | 2017-08-28 | 马波沙星的制备 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107383058B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110283186A (zh) * | 2019-07-19 | 2019-09-27 | 海门慧聚药业有限公司 | 一种马波沙星的晶型及其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4801584A (en) * | 1986-09-12 | 1989-01-31 | Hoffmann-La Roche Inc. | Pyrido(3,2,1-IJ)-1,3,4 benzoxadiazine derivatives |
CN1116849A (zh) * | 1993-01-23 | 1996-02-14 | 辉瑞大药厂 | 生产三环化合物的方法 |
CN102060860A (zh) * | 2011-01-07 | 2011-05-18 | 安徽美诺华药物化学有限公司 | 一种马波沙星的制备方法 |
CN102617595A (zh) * | 2012-03-23 | 2012-08-01 | 江西华士药业有限公司 | 氟喹诺酮类抗菌药马波沙星的制备方法 |
CN102712598A (zh) * | 2009-11-19 | 2012-10-03 | 新梅斯托克尔卡·托瓦纳·兹德拉维尔公司 | 制备马波沙星及其中间体的方法 |
-
2017
- 2017-08-28 CN CN201710749919.4A patent/CN107383058B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4801584A (en) * | 1986-09-12 | 1989-01-31 | Hoffmann-La Roche Inc. | Pyrido(3,2,1-IJ)-1,3,4 benzoxadiazine derivatives |
CN1116849A (zh) * | 1993-01-23 | 1996-02-14 | 辉瑞大药厂 | 生产三环化合物的方法 |
CN102712598A (zh) * | 2009-11-19 | 2012-10-03 | 新梅斯托克尔卡·托瓦纳·兹德拉维尔公司 | 制备马波沙星及其中间体的方法 |
CN102060860A (zh) * | 2011-01-07 | 2011-05-18 | 安徽美诺华药物化学有限公司 | 一种马波沙星的制备方法 |
CN102617595A (zh) * | 2012-03-23 | 2012-08-01 | 江西华士药业有限公司 | 氟喹诺酮类抗菌药马波沙星的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN107383058A (zh) | 2017-11-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2641897T3 (en) | A process for the preparation of 6- (7 - ((1-aminocyclopropyl) methoxy) -6-methoxy-quinolin-4-yloxy) -N-methyl-1-naphthamide and synthetic intermediates thereof | |
US9573932B2 (en) | Synthesis of intermediates in the preparation of ALK inhibitor | |
CA2493227A1 (en) | Preparation of 1h-imidazo[4,5-c]quinolin-4-amines via1h-imidazo [4,5-c]quinolin-4-phthalimide intermediates | |
EP2707367B1 (en) | Methods for preparing naphthyridines | |
CN108368126B (zh) | 用于制备1,3-苯并间二氧杂环戊烯杂环化合物的方法 | |
JP5916721B2 (ja) | 集中的還元的アミノ化によるフェロキンの合成方法 | |
CN107383058B (zh) | 马波沙星的制备 | |
CN103509025A (zh) | 一种盐酸依匹斯汀及其中间体的制备方法 | |
CN101374810A (zh) | α7烟碱型乙酰胆碱受体的调节剂及其治疗用途 | |
CN107513053A (zh) | 一种西他沙星水合物的制备方法 | |
PT2488497E (pt) | Processo para o fabrico de ácido 2-[(3,5-difluoro-3¿-metoxi- 1,1¿-bifenil-4-il)amino]nicotínico | |
EP3692030B1 (en) | Process for the preparation of ridinilazole using acid addition salts | |
CN111233866B (zh) | 托法替尼或其盐的制备方法 | |
CN104592222B (zh) | 抗血小板药物azd6482的制备方法 | |
CN102786543A (zh) | 咪唑并[1,2-a]吡啶-6-硼酸频哪醇酯及其衍生物的制备方法 | |
RU2630700C2 (ru) | СПОСОБЫ ПОЛУЧЕНИЯ 5-[2-[7-(ТРИФТОРМЕТИЛ)-5-[4-(ТРИФТОРМЕТИЛ)ФЕНИЛ]ПИРАЗОЛО[1,5-a]ПИРИМИДИН-3-ИЛ]ЭТИНИЛ]-2-ПИРИДИНАМИНА | |
JP2013537534A (ja) | 化合物osi−906の調製のためのプロセス | |
KR100975895B1 (ko) | 피로나리딘의 제조방법 및 이를 위한 중간체 | |
CN110627768B (zh) | 一种莫西沙星降解杂质j的制备方法 | |
CN107176948B (zh) | 匹莫苯丹的制备 | |
CN106831761B (zh) | 顺式四氢-1H-吡咯并[3,4-b]吡啶-2,5(3H,6H)-二酮的合成方法 | |
CN102219744B (zh) | 一种替米沙坦的中间体的制备方法及一种中间体化合物 | |
JP2013517235A (ja) | インダゾール−3−カルボン酸及びn−(s)−1−アザビシクロ[2.2.2]オクタ−3−イル−1h−インダゾール−3−カルボキサミド塩酸塩の調製方法 | |
CN109928975B (zh) | 一种瑞博西尼的工业化制备方法 | |
CN106432095B (zh) | 匹莫苯丹关键中间体6-(3,4-二氨基苯基)-5-甲基-4,5-二氢哒嗪-3(2h)-酮的制备 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: 226123 No. 18 Qinghua Road, three Factory Street, Haimen City, Nantong, Jiangsu Patentee after: Jiangsu Huiju Pharmaceutical Co.,Ltd. Patentee after: Southeast University Address before: 226123 No. 18 Qinghua Road, three Factory Street, Haimen City, Nantong, Jiangsu Patentee before: WISDOM PHARMACEUTICAL Co.,Ltd. Patentee before: Southeast University Address after: 226123 No. 18 Qinghua Road, three Factory Street, Haimen City, Nantong, Jiangsu Patentee after: Jiangsu Huiju Pharmaceutical Co.,Ltd. Patentee after: Southeast University Address before: 226123 No. 18 Qinghua Road, three Factory Street, Haimen City, Nantong, Jiangsu Patentee before: Jiangsu Huiju Pharmaceutical Co.,Ltd. Patentee before: Southeast University |