ES2067456T3 - Nuevos derivados de aminoacidos, procedimientos para su preparacion y composicion farmaceutica que los comprende. - Google Patents
Nuevos derivados de aminoacidos, procedimientos para su preparacion y composicion farmaceutica que los comprende.Info
- Publication number
- ES2067456T3 ES2067456T3 ES88109430T ES88109430T ES2067456T3 ES 2067456 T3 ES2067456 T3 ES 2067456T3 ES 88109430 T ES88109430 T ES 88109430T ES 88109430 T ES88109430 T ES 88109430T ES 2067456 T3 ES2067456 T3 ES 2067456T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- procedures
- pharmaceutical composition
- acil
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
UN COMPUESTO DE FORMULA: (FIG. A), DONDE R1 ES ALQUILO INFERIOR, OPCIONALMENTE SUSTITUIDO CON UN SUSTITUYENTE ELEGIDO DEL GRUPO QUE CONSTA DE ACILO, HIDROXI, ALCOXI INFERIOR, ARILO, ALQUILO INFERIOR Y UN GRUPO DE FORMULA -N(R5)(R6), EN LA QUE R5 ES HIDROGENO O ACILO, Y R6 ES HIDROGENO O ALQUILO INFERIOR, ARILO O AMINO, OPCIONALMENTE SUSTITUIDO CON SUSTITUYENTE(S) ELEGIDO(S) DEL GRUPO QUE CONSTA DE ALQUILO INFERIOR Y ACILO; Y R2 ES HIDROGENO O ALQUILO INFERIOR; O R1 Y R2 SE TOMAN JUNTOS CON EL ATOMO DE NITROGENO UNIDO, PARA FORMAR UN GRUPO HETEROCICLICO, OPCIONALMENTE SUSTITUIDO CON SUSTITUYENTE(S) ELEGIDO(S) DEL GRUPO QUE CONSTA DE ALQUILO INFERIOR, OXO O ACILO; R3 ES HIDROGENO O ALQUILO INFERIOR; Y R4 ES ALQUILO INFERIOR; Y SU SAL FARMACEUTICAMENTE ACEPTABLE; PROCEDIMIENTOS PARA SU OBTENCION Y COMPOSICION FARMACEUTICA QUE LO CONTIENE.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878714597A GB8714597D0 (en) | 1987-06-22 | 1987-06-22 | Peptide compounds |
GB878725511A GB8725511D0 (en) | 1987-10-30 | 1987-10-30 | Peptide compounds |
GB888805389A GB8805389D0 (en) | 1988-03-07 | 1988-03-07 | New peptide compounds process for preparation thereof & pharmaceutical composition comprising same |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2067456T3 true ES2067456T3 (es) | 1995-04-01 |
Family
ID=27263470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88109430T Expired - Lifetime ES2067456T3 (es) | 1987-06-22 | 1988-06-14 | Nuevos derivados de aminoacidos, procedimientos para su preparacion y composicion farmaceutica que los comprende. |
Country Status (20)
Country | Link |
---|---|
US (2) | US4921855A (es) |
EP (1) | EP0300189B1 (es) |
JP (1) | JPH0625147B2 (es) |
KR (1) | KR950003926B1 (es) |
CN (1) | CN1026892C (es) |
AR (1) | AR247733A1 (es) |
AT (1) | ATE113585T1 (es) |
AU (1) | AU617674B2 (es) |
DE (1) | DE3851986T2 (es) |
DK (1) | DK340088A (es) |
ES (1) | ES2067456T3 (es) |
FI (1) | FI96202C (es) |
HK (1) | HK18796A (es) |
HU (2) | HU202212B (es) |
IE (1) | IE65807B1 (es) |
IL (1) | IL86782A (es) |
NO (1) | NO175371C (es) |
PH (1) | PH27181A (es) |
PT (1) | PT87754B (es) |
RU (1) | RU1801107C (es) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI870474A (fi) * | 1986-02-07 | 1987-08-08 | Ciba Geigy Ag | Med svavelhaltiga grupper substituerade 5-amino-4-hydroxivalerylderivat. |
FI89058C (fi) * | 1987-02-27 | 1993-08-10 | Yamanouchi Pharma Co Ltd | Foerfarande foer framstaellning av som remin-inhibitorer anvaenda 2-(l-alanyl-l-histidylamino)-butanol-derivat |
DE68916271T2 (de) * | 1988-01-26 | 1995-02-23 | Sankyo Co | Renin inhibierende Polypeptide, ihre Herstellung und Anwendung. |
US5151513A (en) * | 1988-04-29 | 1992-09-29 | E. R. Squibb & Sons, Inc. | N-heterocyclic alcohol derivatives |
US4900746A (en) * | 1988-07-01 | 1990-02-13 | G. D. Searle & Co. | Ethereal N-terminal aminodiol amino acid derivatives as anti-hypertensive agents |
AU616282B2 (en) * | 1988-07-01 | 1991-10-24 | G.D. Searle & Co. | Ethereal N-terminal aminodiol amino acid derivatives as anti-hypertensive agents |
US5229420A (en) * | 1988-07-01 | 1993-07-20 | G. D. Searle & Co. | Ethereal N-terminal aminodiol amino acid derivatives as anti-hypertensive agents |
US4902706A (en) * | 1988-07-01 | 1990-02-20 | G. D. Searle & Co. | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as antihypertensive agents |
US5229369A (en) * | 1988-07-01 | 1993-07-20 | G. D. Searle & Co. | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents |
NO892728L (no) * | 1988-07-01 | 1990-01-02 | Searle & Co | Aminoalkyl-aminokarbonyl-aminodiolaminosyre derivater somanti-hypertensive midler. |
US4900745A (en) * | 1988-07-01 | 1990-02-13 | G. D. Searle & Co. | Poly(aminoalkyl)aminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents |
EP0355331A3 (en) * | 1988-07-01 | 1991-08-14 | G.D. Searle & Co. | Poly(aminoalkyl)aminocarbonyl aminoacyl aminodiol amino acid derivatives as anti-hypertensive agents |
US5246959A (en) * | 1988-07-01 | 1993-09-21 | G. D. Searle & Co. | Poly(aminoalkyl)aminocarbonyl aminoacyl aminodiol amino acid derivatives as anti-hypertensive agents |
JPH03204860A (ja) * | 1989-05-02 | 1991-09-06 | Japan Tobacco Inc | レニン阻害活性を有する新規アミノ酸誘導体 |
IL95634A0 (en) * | 1989-09-12 | 1991-06-30 | Hoechst Ag | Amino acid derivatives with renin-inhibiting properties,a process for the preparation thereof,compositions containing them and the use thereof |
US5104869A (en) * | 1989-10-11 | 1992-04-14 | American Cyanamid Company | Renin inhibitors |
US5180744A (en) * | 1989-12-04 | 1993-01-19 | G. D. Searle & Co. | Aralkyl-N-terminal amino hydroxy |
US5147888A (en) * | 1989-12-04 | 1992-09-15 | G. D. Searle & Co. | N-terminal indolyy indolylalkylaminodiol β-amino acid derivatives |
US5217991A (en) * | 1989-12-04 | 1993-06-08 | G. D. Searle & Co. | Cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives |
US5217989A (en) * | 1989-12-04 | 1993-06-08 | G. D. Searle & Co. | Benothiophenyl/benzothiophenylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives |
US5223532A (en) * | 1989-12-04 | 1993-06-29 | G. D. Searle & Co. | Chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino derivatives |
US5175181A (en) * | 1989-12-04 | 1992-12-29 | G. D. Searle & Co. | Imidazolyl/imidazolylalkyl-N-terminal amino hydroxy |
US5215996A (en) * | 1989-12-04 | 1993-06-01 | G. D. Searle & Co. | Naphthyridinyl/naphthyridinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives |
US5223514A (en) * | 1989-12-04 | 1993-06-29 | G. D. Searle & Co. | Quinolinyl/quinolinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives |
EP0431520B1 (en) * | 1989-12-04 | 1995-02-08 | G.D. Searle & Co. | Heterocyclic acyl aminodiol beta-amino acid derivatives |
US5212175A (en) * | 1989-12-04 | 1993-05-18 | G. D. Searle & Co. | Benzothiophenyl benzothiophenylalkyl-N-terminal amino hydroxy β-amino acid derivatives |
US5175170A (en) * | 1989-12-04 | 1992-12-29 | G. D. Searle & Co. | β-amino acid derivatives |
US5223512A (en) * | 1989-12-04 | 1993-06-29 | G. D. Searle & Co. | Quinolonyl/quinolonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives |
US5179102A (en) * | 1989-12-04 | 1993-01-12 | G. D. Searle & Co. | Naphthyridinyl/naphthyridinylalkyl-n-terminal anino hydroxy β-amino acid derivatives |
US5223534A (en) * | 1989-12-04 | 1993-06-29 | G. D. Searle & Co. | Benzofuuranyl/benofuranylaklyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives |
US5180725A (en) * | 1989-12-04 | 1993-01-19 | G. D. Searle & Co. | Quinoxalinyl/quinoxaliy; alkyl-N-terminal amino hydroxy |
US5171751A (en) * | 1989-12-04 | 1992-12-15 | G. D. Searle & Co. | Benzofuran/benzofuranalkyl-N-terminal amino hydroxy |
US5217988A (en) * | 1989-12-04 | 1993-06-08 | G. D. Searle & Co. | Indolyl indolylakyl-N-terminal cycloalkoxy-C-terminal amino hydroxyβ-amino acid derivatives |
US5210095A (en) * | 1989-12-04 | 1993-05-11 | G. D. Searle & Co. | Chromonyl/chromonylalkyl-N-terminal amino hydroxy |
US5216013A (en) * | 1989-12-04 | 1993-06-01 | G. D. Searle & Co. | Aralkyl-N-terminal cycloalkoxy-C terminal amino hydroxy β-amino acid derivatives |
US5231111A (en) * | 1989-12-04 | 1993-07-27 | G. D. Searle & Co. | Imidazolyl/imidazolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives |
US5254682A (en) * | 1989-12-08 | 1993-10-19 | Merck & Co., Inc. | Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs |
US5194605A (en) * | 1989-12-08 | 1993-03-16 | Merck & Co., Inc. | Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3S,4S)-5-cyclohexyl-3,4-di-hydroxy pentanoic acid or 2-substituted (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhexanoic acid or its analogs |
DE4008403A1 (de) * | 1990-03-16 | 1991-09-19 | Merck Patent Gmbh | Glykolsaeurederivate |
US5430022A (en) * | 1990-05-14 | 1995-07-04 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compound and its preparation |
US5278161A (en) * | 1990-06-28 | 1994-01-11 | Hoffmann-La Roche Inc. | Amino acid derivatives useful as renin inhibitors |
CA2044564A1 (en) * | 1990-06-28 | 1991-12-29 | Quirico Branca | Amino acid derivatives |
IL99389A0 (en) * | 1990-09-17 | 1992-08-18 | Fujisawa Pharmaceutical Co | Amino acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
ZA921381B (en) * | 1991-03-01 | 1992-11-25 | Fujisawa Pharmaceutical Co | New use of amino acid derivatives |
WO1992017456A1 (en) * | 1991-03-26 | 1992-10-15 | Fujisawa Pharmaceutical Co., Ltd. | Amino acid derivative and salt thereof |
US5223535A (en) * | 1991-10-29 | 1993-06-29 | G. D. Searle & Co. | Propargyl glycine amino propargyl diol compounds for treatment of hypertension |
US5330996A (en) * | 1991-10-29 | 1994-07-19 | G. D. Searle & Co. | Amino acyl amino propargyl diol compounds for treatment of hypertension |
US5227401A (en) * | 1991-10-29 | 1993-07-13 | G. D. Searle & Co. | Ethynyl alanine amino diol compounds for treatment of hypertension |
GB9127041D0 (en) * | 1991-12-20 | 1992-02-19 | Fujisawa Pharmaceutical Co | New use |
JP2578044B2 (ja) * | 1992-03-14 | 1997-02-05 | 呉羽化学工業株式会社 | フェニルアラニン−グリシン誘導体、その製造方法、及びその誘導体を含有する抗腫瘍剤 |
RU94046317A (ru) * | 1992-07-02 | 1996-10-20 | Фудзисава Фармасьютикал Ко. | Новое синтетическое промежуточное соединение для получения производных и способы получения производных аминокислот |
US5246969A (en) * | 1992-07-20 | 1993-09-21 | G. D. Searle & Co. | Di-propargyl-containing aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension |
US5317039A (en) * | 1992-07-20 | 1994-05-31 | G. D. Searle & Co. | Cyclopropyl-alanine aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension |
US5268391A (en) * | 1992-07-20 | 1993-12-07 | C. D. Searle & Co. | Propargyl-terminated cycloalkylalkyl-P2-site substituted aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension |
US5314920A (en) * | 1992-07-20 | 1994-05-24 | G. D. Searle & Co. | Ethynyl-alanine aryl/alkylsulfonyl-terminated amino-diol compounds for treatment of hypertension |
US5252591A (en) | 1992-08-14 | 1993-10-12 | G. D. Searle & Company | Pyridinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5212185A (en) * | 1992-08-14 | 1993-05-18 | G. D. Searle & Co. | Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5298505A (en) * | 1992-08-14 | 1994-03-29 | G. D. Searle & Co. | Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension |
US5422349A (en) * | 1992-08-14 | 1995-06-06 | G. D. Seale & Co. | Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5373017A (en) * | 1992-08-14 | 1994-12-13 | G. D. Searle & Co. | Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension |
US5312838A (en) * | 1992-09-21 | 1994-05-17 | G. D. Searle & Co. | β-alanineamide aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension |
JP3134936B2 (ja) * | 1992-10-16 | 2001-02-13 | 沖電気工業株式会社 | 衝撃センサ |
GB9313330D0 (en) * | 1993-06-28 | 1993-08-11 | Fujisawa Pharmaceutical Co | New compound and its preparation |
US5414018A (en) * | 1993-09-24 | 1995-05-09 | G. D. Searle & Co. | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension |
US5383540A (en) * | 1993-10-04 | 1995-01-24 | Ford Motor Company | Torque converter bypass clutch piston-pump drive for an automatic transmission |
US5416119A (en) * | 1993-10-25 | 1995-05-16 | G. D. Searle & Co. | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing cycloalkyl-alanine amino-diol compounds for treatment of hypertension |
US5432201A (en) * | 1993-11-22 | 1995-07-11 | G. D. Searle & Co. | Alkylaminoalkyl-sulfonyl-terminated β-alanineamide amino-diol compounds for treatment of hypertension |
US5780494A (en) * | 1994-11-14 | 1998-07-14 | G. D. Searle & Co. | Piperidinyl-terminated alkylamino ethynl alanine amino diol compounds for treatment of hypertension |
US6750344B1 (en) * | 1997-09-05 | 2004-06-15 | Isis Pharmaceuticals, Inc. | Amine compounds and combinatorial libraries comprising same |
DE10032878A1 (de) * | 2000-07-06 | 2002-01-17 | Bayer Ag | Anthelmintika zur Verhinderung von parasitären Infektionen bei Mensch und Tier |
AR058805A1 (es) | 2005-09-09 | 2008-02-27 | Smithkline Beecham Corp | Derivados biciclicos de piridina utiles como agentes antipsicoticos |
EP2640721B1 (en) | 2010-11-16 | 2018-06-06 | Texas Heart Institute | Agonists that enhance binding of integrin-expressing cells to integrin receptors |
CN104510481A (zh) * | 2013-09-26 | 2015-04-15 | 温州市高德医疗器械有限公司 | 高血压三项酶抑制剂真空采血管及其制作方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4073905A (en) * | 1971-07-19 | 1978-02-14 | Boehringer Ingelheim Gmbh | 2-Amino-4-phenyl-2-imidazolines and salts thereof |
JPS60163899A (ja) * | 1984-02-03 | 1985-08-26 | Sankyo Co Ltd | レニン阻害ペプチド類 |
US4652551A (en) * | 1984-06-22 | 1987-03-24 | Abbott Laboratories | Renin inhibiting compounds |
US4845079A (en) * | 1985-01-23 | 1989-07-04 | Luly Jay R | Peptidylaminodiols |
DK34086A (da) * | 1985-01-23 | 1986-07-24 | Abbott Lab | Peptidylaminodioler |
JPS61236770A (ja) * | 1985-04-15 | 1986-10-22 | Kissei Pharmaceut Co Ltd | 新規なアミノ酸誘導体 |
US4826815A (en) * | 1985-05-17 | 1989-05-02 | Abbott Laboratories | Renin inhibiting compounds |
EP0206807A3 (en) * | 1985-06-28 | 1988-01-20 | Kissei Pharmaceutical Co. Ltd. | Novel amino acid derivatives |
IL81234A (en) * | 1986-01-16 | 1992-09-06 | Abbott Lab | Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them |
JPS63503380A (ja) * | 1986-01-16 | 1988-12-08 | アボット・ラボラトリーズ | ペプチド類似体 |
EP0244083A3 (en) * | 1986-04-01 | 1989-11-15 | Kissei Pharmaceutical Co. Ltd. | Amino acid derivatives |
US4656269A (en) * | 1986-04-15 | 1987-04-07 | Kissei Pharmaceutical Co., Ltd. | Histidine derivatives |
US4895834A (en) * | 1986-12-15 | 1990-01-23 | Warner-Lambert Company | Renin inhibitors III |
-
1988
- 1988-06-09 US US07/204,549 patent/US4921855A/en not_active Expired - Fee Related
- 1988-06-13 IE IE177888A patent/IE65807B1/en not_active IP Right Cessation
- 1988-06-14 DE DE3851986T patent/DE3851986T2/de not_active Expired - Fee Related
- 1988-06-14 AT AT88109430T patent/ATE113585T1/de not_active IP Right Cessation
- 1988-06-14 EP EP88109430A patent/EP0300189B1/en not_active Expired - Lifetime
- 1988-06-14 ES ES88109430T patent/ES2067456T3/es not_active Expired - Lifetime
- 1988-06-16 IL IL86782A patent/IL86782A/xx not_active IP Right Cessation
- 1988-06-16 FI FI882875A patent/FI96202C/fi not_active IP Right Cessation
- 1988-06-17 PT PT87754A patent/PT87754B/pt not_active IP Right Cessation
- 1988-06-17 PH PH37089A patent/PH27181A/en unknown
- 1988-06-18 KR KR1019880007364A patent/KR950003926B1/ko not_active IP Right Cessation
- 1988-06-21 DK DK340088A patent/DK340088A/da not_active Application Discontinuation
- 1988-06-21 AR AR88311180A patent/AR247733A1/es active
- 1988-06-21 HU HU883164A patent/HU202212B/hu not_active IP Right Cessation
- 1988-06-21 RU SU884356019A patent/RU1801107C/ru active
- 1988-06-21 CN CN88103878A patent/CN1026892C/zh not_active Expired - Fee Related
- 1988-06-21 AU AU18190/88A patent/AU617674B2/en not_active Ceased
- 1988-06-21 JP JP63153041A patent/JPH0625147B2/ja not_active Expired - Lifetime
- 1988-06-21 NO NO882732A patent/NO175371C/no unknown
-
1990
- 1990-01-08 US US07/462,117 patent/US5142048A/en not_active Expired - Fee Related
-
1995
- 1995-06-22 HU HU95P/P00356P patent/HU211977A9/hu unknown
-
1996
- 1996-02-01 HK HK18796A patent/HK18796A/xx not_active IP Right Cessation
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