AR247733A1 - Procedimiento para obtener nuevos derivados de aminoacidos - Google Patents

Procedimiento para obtener nuevos derivados de aminoacidos

Info

Publication number
AR247733A1
AR247733A1 AR88311180A AR31118088A AR247733A1 AR 247733 A1 AR247733 A1 AR 247733A1 AR 88311180 A AR88311180 A AR 88311180A AR 31118088 A AR31118088 A AR 31118088A AR 247733 A1 AR247733 A1 AR 247733A1
Authority
AR
Argentina
Prior art keywords
ilo
alkyl
substituted
alcoxy
morfolino
Prior art date
Application number
AR88311180A
Other languages
English (en)
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878714597A external-priority patent/GB8714597D0/en
Priority claimed from GB878725511A external-priority patent/GB8725511D0/en
Priority claimed from GB888805389A external-priority patent/GB8805389D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of AR247733A1 publication Critical patent/AR247733A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PREPARACION DE COMPUESTO DE FORMULA I, DONDE R1 ES ALQUILO SUSTITUIDO O NO POR HO, ALCOXI, FENILO, ALQUILTIO O DE R10R9NCO-, R11-CO- O R11-SO2-, DONDE R9 Y R10 SON H, FENILO, TRAZOLILO, PIRIDILO, MORFOLINO O ALQUILO SUSTITUIDO O NO CON FENILO, ALCOXI, PIRIDILO O MORFOLINO O R9 Y R10 CON EL N FORMAN MORFOLINO, TIOMORFOLINO, TETRAHIDROPIRIDIN-1-ILO O PIPERAZINIL-1-ILO SUSTITUIDO POR ALQUILO Y R11 ES FENILO, O ALQUILO SUSTITUIDO O NO POR ALCOXI, MONO O DIALQUIL, AMINO O ALCOXI SUSTITUIDO O NO POR ALCANOILO O FENILO; R1 ES R5R6N-, R5 ES H O DE FORMULAS II R10R9NCO-, R11-CO- O R11-SO2 ; R11 ES FENILO, ALQUILO, SUSTITUIDO O NO POR ALCOXI, MONO O DIALQUIL, AMINO, ALCOXI SUSTITUIDO O NO POR ALCANOILO O FENILO, O DE FORMULA R6R5N- DONDE R5 ES H O DE FORMULA II, EN LA QUE R6 ES ALQUILO O H, FENILO O AMINO SUSTITUIDO O NO POR ALQUILO O POR UN GRUPO DE FORMULAS II, R2 ES H, ALQUILO Y R1 Y R2 JUNTOS CON EL N FORMAN: MORFOLINO, TIOMORFOLINO O SUS OXIDOS, PIRROLIDINIL-1-ILO, PIRAZOLIDIN-1-ILO, P IPERIDINO, PIPERAZIN-1-ILO; TIAZOLIDIN-3-ILO O SUS OXIDOS, OXAZOLIDIN-3- ILO, PERHIDROPIRAZIDIN-1-ILO TETRAHIDROPIRIDIN-1-ILO, HEXAMETILENIMINO O 1, 4-DIAZABICICLO(4.3.0)NONAN-4-ILO, SUSTITUIDO O NO POR: ALQUILO, HIDROXIALQUILO, ALCOXI, ALQUILO, MORFOLINOCARBONILOALQUILO, OXO, BENZOILGLICILO Y II ENTRE OTROS, DONDE R3 ES H O ALQUILO, R4 ES ALQUILO Y SUS SALES, QUE COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA III, DONDE R8 ES H UN GRUPO N-PROTECTOR CON UN COMPUESTO DE FORMULA IV.
AR88311180A 1987-06-22 1988-06-21 Procedimiento para obtener nuevos derivados de aminoacidos AR247733A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878714597A GB8714597D0 (en) 1987-06-22 1987-06-22 Peptide compounds
GB878725511A GB8725511D0 (en) 1987-10-30 1987-10-30 Peptide compounds
GB888805389A GB8805389D0 (en) 1988-03-07 1988-03-07 New peptide compounds process for preparation thereof & pharmaceutical composition comprising same

Publications (1)

Publication Number Publication Date
AR247733A1 true AR247733A1 (es) 1995-03-31

Family

ID=27263470

Family Applications (1)

Application Number Title Priority Date Filing Date
AR88311180A AR247733A1 (es) 1987-06-22 1988-06-21 Procedimiento para obtener nuevos derivados de aminoacidos

Country Status (20)

Country Link
US (2) US4921855A (es)
EP (1) EP0300189B1 (es)
JP (1) JPH0625147B2 (es)
KR (1) KR950003926B1 (es)
CN (1) CN1026892C (es)
AR (1) AR247733A1 (es)
AT (1) ATE113585T1 (es)
AU (1) AU617674B2 (es)
DE (1) DE3851986T2 (es)
DK (1) DK340088A (es)
ES (1) ES2067456T3 (es)
FI (1) FI96202C (es)
HK (1) HK18796A (es)
HU (2) HU202212B (es)
IE (1) IE65807B1 (es)
IL (1) IL86782A (es)
NO (1) NO175371C (es)
PH (1) PH27181A (es)
PT (1) PT87754B (es)
RU (1) RU1801107C (es)

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US5151513A (en) * 1988-04-29 1992-09-29 E. R. Squibb & Sons, Inc. N-heterocyclic alcohol derivatives
US5246959A (en) * 1988-07-01 1993-09-21 G. D. Searle & Co. Poly(aminoalkyl)aminocarbonyl aminoacyl aminodiol amino acid derivatives as anti-hypertensive agents
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US5229420A (en) * 1988-07-01 1993-07-20 G. D. Searle & Co. Ethereal N-terminal aminodiol amino acid derivatives as anti-hypertensive agents
US4902706A (en) * 1988-07-01 1990-02-20 G. D. Searle & Co. Aminoalkylaminocarbonyl aminodiol amino acid derivatives as antihypertensive agents
US5229369A (en) * 1988-07-01 1993-07-20 G. D. Searle & Co. Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents
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US5383540A (en) * 1993-10-04 1995-01-24 Ford Motor Company Torque converter bypass clutch piston-pump drive for an automatic transmission
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Also Published As

Publication number Publication date
EP0300189A3 (en) 1990-08-22
DK340088A (da) 1988-12-23
FI882875A0 (fi) 1988-06-16
IL86782A0 (en) 1988-11-30
KR950003926B1 (ko) 1995-04-20
CN1030411A (zh) 1989-01-18
HUT47917A (en) 1989-04-28
JPS6419071A (en) 1989-01-23
FI882875A (fi) 1988-12-23
ES2067456T3 (es) 1995-04-01
FI96202C (fi) 1996-05-27
IE65807B1 (en) 1995-11-15
NO882732L (no) 1988-12-23
DE3851986D1 (de) 1994-12-08
IL86782A (en) 1993-04-04
JPH0625147B2 (ja) 1994-04-06
DK340088D0 (da) 1988-06-21
CN1026892C (zh) 1994-12-07
IE881778L (en) 1988-12-22
HU202212B (en) 1991-02-28
AU1819088A (en) 1988-12-22
NO882732D0 (no) 1988-06-21
PH27181A (en) 1993-04-16
NO175371C (no) 1994-10-05
HU211977A9 (en) 1996-01-29
EP0300189B1 (en) 1994-11-02
RU1801107C (ru) 1993-03-07
HK18796A (en) 1996-02-09
ATE113585T1 (de) 1994-11-15
KR890000434A (ko) 1989-03-14
PT87754A (pt) 1988-07-01
EP0300189A2 (en) 1989-01-25
US4921855A (en) 1990-05-01
NO175371B (no) 1994-06-27
US5142048A (en) 1992-08-25
DE3851986T2 (de) 1995-03-09
AU617674B2 (en) 1991-12-05
PT87754B (pt) 1992-10-30
FI96202B (fi) 1996-02-15

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