ES2070175T3 - Derivados de acido 4-oxoquinolino-3-carboxilico, su preparacion y su uso. - Google Patents

Derivados de acido 4-oxoquinolino-3-carboxilico, su preparacion y su uso.

Info

Publication number
ES2070175T3
ES2070175T3 ES89307423T ES89307423T ES2070175T3 ES 2070175 T3 ES2070175 T3 ES 2070175T3 ES 89307423 T ES89307423 T ES 89307423T ES 89307423 T ES89307423 T ES 89307423T ES 2070175 T3 ES2070175 T3 ES 2070175T3
Authority
ES
Spain
Prior art keywords
oxoquinolino
carboxilico
derivatives
preparation
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89307423T
Other languages
English (en)
Inventor
Masayuki C O Sankyo Comp Iwata
Tomio Kimura
Teruhiko Inoue
Yoshimi Fujihara
Tetsushi Katsube
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2070175T3 publication Critical patent/ES2070175T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA (I), EN LA QUE R1 ES METOXI FLUORADO, R2 ES UN GRUPO HETEROCICLICO QUE CONTIENE NITROGENO; Y R3 ES HIDROGENO O AMINO; Y SUS SALES, ESTERES, AMIDAS Y PRECURSORES FARMACEUTICAMENTE ACEPTABLES, SON AGENTES BACTERIANOS VALIOSOS, QUE SE PUEDEN OBTENER POR REACCION DE UN COMPUESTO SIMILAR AL DE LA FORMULA (I), PERO EN EL QUE R2 SE SUSTITUYE POR UN ATOMO DE HALOGENO, CON UN COMPUESTO QUE PROPORCIONA EL GRUPO R2 NECESARIO.
ES89307423T 1988-07-20 1989-07-20 Derivados de acido 4-oxoquinolino-3-carboxilico, su preparacion y su uso. Expired - Lifetime ES2070175T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18055788 1988-07-20
JP22422088 1988-09-07

Publications (1)

Publication Number Publication Date
ES2070175T3 true ES2070175T3 (es) 1995-06-01

Family

ID=26500036

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89307423T Expired - Lifetime ES2070175T3 (es) 1988-07-20 1989-07-20 Derivados de acido 4-oxoquinolino-3-carboxilico, su preparacion y su uso.

Country Status (14)

Country Link
US (4) US5348961A (es)
EP (2) EP0610958B1 (es)
KR (2) KR950010325B1 (es)
CN (1) CN1028226C (es)
AT (2) ATE206401T1 (es)
AU (1) AU618823B2 (es)
CA (1) CA1335670C (es)
DE (2) DE68920654T2 (es)
DK (1) DK175617B1 (es)
ES (1) ES2070175T3 (es)
FI (1) FI95130C (es)
GR (1) GR3015818T3 (es)
IE (1) IE68941B1 (es)
NO (1) NO175256C (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
DE4015299A1 (de) * 1990-05-12 1991-11-14 Bayer Ag Verfahren zur herstellung von 3-amino-2-(het)-aroyl-acrylsaeurederivaten
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
JP3165742B2 (ja) * 1991-07-16 2001-05-14 中外製薬株式会社 キノロンカルボン酸誘導体の製造方法
EP0545866A1 (de) * 1991-12-06 1993-06-09 Ciba-Geigy Ag Verfahren zur Herstellung von Trifluorbenzolderivaten
TW222272B (es) * 1992-05-26 1994-04-11 Ss Seiyaku Kk
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
DE4232505A1 (de) * 1992-09-29 1994-03-31 Degussa Verfahren zur Reduktion von Carbonsäuren oder Carbonsäurederivaten sowie neue Verbindungen
CA2152828A1 (en) * 1993-03-16 1994-07-07 Shin-Ichi Uesato 8-methoxy-quinolonecarboxylic acid derivatives
FR2706459B1 (fr) * 1993-06-17 1995-08-04 Bouchara Sa Nouveaux dérivés quinoloniques, leur procédé d'obtention et les compositions pharmaceutiques qui en contiennent.
US6964611B2 (en) * 1996-12-30 2005-11-15 Walker Digital, Llc System and method for automated play of lottery games
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
SK286420B6 (sk) * 1997-09-15 2008-09-05 The Procter & Gamble Company Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie
JP4553338B2 (ja) 1998-11-18 2010-09-29 旭硝子株式会社 アミノアクリル酸誘導体およびその製造方法
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
AU2001232238B2 (en) 2000-02-09 2005-03-24 Daiichi Pharmaceutical Co., Ltd. Anti-acid-fast bacterial agents containing pyridonecarboxylic acids as the active ingredient
US6964966B2 (en) * 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) * 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
EP1660495B1 (en) 2003-09-04 2007-07-11 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
ES2232309B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Procedimiento simplificado para la obtencion de gatifloxacino.
DE102004035203A1 (de) 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
DE102006005861A1 (de) 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
ES2284380B1 (es) * 2006-03-10 2008-11-01 Quimica Sintetica S.A. Procedimiento para la preparacion de moxifloxacino y moxifloxacino clorhidrato.
CA2647454A1 (en) * 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
BRPI0709772B8 (pt) * 2006-03-28 2021-05-25 The Protecter & Gamble Company sais de malato e polimorfos do ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-diidro-8-metóxi-4-oxo-3-quinolinocarboxílico
US7528264B2 (en) * 2006-03-28 2009-05-05 The Procter & Gamble Company Hydride reduction process for preparing quinolone intermediates
CN100415212C (zh) * 2006-07-21 2008-09-03 哈药集团制药总厂 一种含乳酸卡德沙星的口服制剂
WO2008144536A1 (en) 2007-05-17 2008-11-27 Walker Digital, Llc Group play of lottery game
CN101775005B (zh) * 2009-01-13 2013-12-04 江苏恒瑞医药股份有限公司 盐酸卡屈沙星i型结晶及其制备方法
CN108129404B (zh) * 2018-01-30 2020-05-01 凯瑞斯德生化(苏州)有限公司 手性哌嗪酮衍生物的合成方法
CN108299317A (zh) * 2018-03-20 2018-07-20 爱斯特（成都）生物制药股份有限公司 1,4-二氮杂螺[5,5]十一烷盐酸盐的合成方法
CN108840814B (zh) * 2018-07-24 2021-09-24 南京药石科技股份有限公司 一种8-氧代-2,6,9-三氮杂螺[4.5]癸烷-2-羧酸叔丁酯制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US4977154A (en) * 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
CN1019114B (zh) * 1986-03-31 1992-11-18 三共株式会社 喹啉-3-羟酸衍生物的制备方法
US4803205A (en) * 1987-08-07 1989-02-07 Warner-Lambert Company Quinolones as antibacterial agents
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent

Also Published As

Publication number Publication date
CA1335670C (en) 1995-05-23
US5073556A (en) 1991-12-17
GR3015818T3 (en) 1995-07-31
KR950011396B1 (ko) 1995-10-02
EP0352123A2 (en) 1990-01-24
US5436367A (en) 1995-07-25
ATE117295T1 (de) 1995-02-15
DE68920654D1 (de) 1995-03-02
KR900001686A (ko) 1990-02-27
EP0610958A3 (en) 1995-03-22
US5348961A (en) 1994-09-20
AU3821889A (en) 1990-01-25
CN1028226C (zh) 1995-04-19
CN1040977A (zh) 1990-04-04
EP0610958A2 (en) 1994-08-17
DK175617B1 (da) 2004-12-27
FI95130B (fi) 1995-09-15
EP0610958B1 (en) 2001-10-04
IE892340L (en) 1990-01-20
DE68929330D1 (de) 2001-11-08
NO175256B (no) 1994-06-13
NO175256C (no) 1994-09-21
DK359289A (da) 1990-01-21
AU618823B2 (en) 1992-01-09
US5496951A (en) 1996-03-05
IE68941B1 (en) 1996-07-24
FI95130C (fi) 1995-12-27
DE68920654T2 (de) 1995-08-31
FI893467A (fi) 1990-01-21
EP0352123A3 (en) 1990-09-05
EP0352123B1 (en) 1995-01-18
DK359289D0 (da) 1989-07-19
KR950010325B1 (ko) 1995-09-14
ATE206401T1 (de) 2001-10-15
NO892952D0 (no) 1989-07-19
NO892952L (no) 1990-01-22
DE68929330T2 (de) 2002-07-04
FI893467A0 (fi) 1989-07-18

Similar Documents

Publication Publication Date Title
ES2070175T3 (es) Derivados de acido 4-oxoquinolino-3-carboxilico, su preparacion y su uso.
ES2054826T3 (es) Peptidos con actividad inhibidora de colagenasa.
UA8022A1 (uk) Спосіб одержання похідних бензімідазолу у вигляді суміші ізомерів або індивідуальних ізомерів у вільному вигляді або у вигляді їх фізіологічно прийнятих солей
CA2247443A1 (en) Substituted 4-hydroxy-phenylalcanoic acid derivatives with agonist activity to ppar-gamma
ES2062974T3 (es) Compuestos de cefalosporina, procedimientos para su preparacion y agentes antibacterianos.
ES2000185A6 (es) Procedimiento para preparar derivados de acidos piridoncaboxilicos
DK149885A (da) Fremgangsmaade til fremstilling af optisk aktive alpha-arylalkansyrer og mellemprodukter til brug herved
DK0625977T3 (da) Piperazinderivater som 5-1A-antagonister
DK0618920T3 (da) Hidtil ukendte phosphonravsyrederivater, fremgangsmåde til fremstilling heraf samt lægemidler indeholdende disse forbindelser
ES8401941A1 (es) Procedimiento para la preparacion de derivados de acido espiro (4.(3+n))-2-aza-3carboxilico.
EP0324387A3 (en) Composition for treatment of ischemic disorder in organs
ES2037665T3 (es) Procedimiento para la preparacion de compuestos heterociclicos que contienen n.
DK0383686T3 (da) Carboxyalkylethere af 2-amino-7-hydroxytetralin samt fremgangsmåde til fremstilling deraf
MY108849A (en) Novel compound
ES2059595T3 (es) Beta-carbonil-carboxiamidas de 1,3-tiazolidinas.
ES475596A1 (es) Procedimiento para la preparacion de derivados de fenoxial- canolaminas
ATE21387T1 (de) Hydrochinonabkoemmlinge, sowie verfahren zu deren herstellung.
ES2052783T3 (es) Procedimiento para la preparacion de 4-alquil-1,4-dihidropiridinas.
FI971177A (fi) Bisyklisiä karboksiamideja 5-HT1A-antagonisteina
ES8702392A1 (es) Un procedimiento para preparar compuestos heterociclicos, en particular compuestos con un anillo de tiadiazinona
DE3673348D1 (de) Heterocyclische aminoverbindungen.
DK128892A (da) Benzyletherderivater
HK1004546A1 (en) Aminoalcohols useful as optical resolving agents

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 352123

Country of ref document: ES