ES483985A1 - Procedimiento para preparar alfa-aril-alfa,alfa-bis(omega- (amino disustituido)alquil)acetamidas - Google Patents
Procedimiento para preparar alfa-aril-alfa,alfa-bis(omega- (amino disustituido)alquil)acetamidasInfo
- Publication number
- ES483985A1 ES483985A1 ES483985A ES483985A ES483985A1 ES 483985 A1 ES483985 A1 ES 483985A1 ES 483985 A ES483985 A ES 483985A ES 483985 A ES483985 A ES 483985A ES 483985 A1 ES483985 A1 ES 483985A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- alpha
- substituted
- compounds
- acetamides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedimiento para preparar alfa-aril-alfa, alfa-bis [omega-(amino disustituído)alquil]acetamidas, de fórmula general: **(Fórmula)** y sus sales de adición de ácido farmacéuticamente aceptables; en donde R1 es alquilo inferior de 1 a 7 átomos de carbono o cicloalquilo de 5 ó 6 átomos de carbono; R2 es alquilo inferior de 1 a 7 átomos de carbono; ó R1 y R2 junto con el átomo de N representan un anillo azamonocíclico que puede contener otro heteroátomo y que esta opcionalmente sustituido con 1 ó 2 grupo fenilo o alquilo inferior de 1 a 4 átomos de carbono; Ar es piridilo, fenilo, trifluormetilfenilo, bifenililo, fenilo sustituido con 1 ó 2 radicales halógeno o alquilo inferior de 1 a 4 átomos de carbono, 1 ó 2-naftilo opcionalmente sustituido con halógeno o alquilo inferior de 1 a 4 átomos de carbono; o ciclohexilo; y Alq1 y Alq2 son independientemente radicales alquileno de 2 a 4 átomos de carbono.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/940,527 US4217306A (en) | 1978-05-01 | 1978-09-08 | α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]-acetamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES483985A1 true ES483985A1 (es) | 1980-04-16 |
Family
ID=25474978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES483985A Expired ES483985A1 (es) | 1978-09-08 | 1979-09-07 | Procedimiento para preparar alfa-aril-alfa,alfa-bis(omega- (amino disustituido)alquil)acetamidas |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4217306A (es) |
| JP (1) | JPS5592350A (es) |
| AT (3) | AT364813B (es) |
| AU (1) | AU5068679A (es) |
| BE (1) | BE878662A (es) |
| CA (1) | CA1136622A (es) |
| DE (1) | DE2936287A1 (es) |
| DK (1) | DK374879A (es) |
| ES (1) | ES483985A1 (es) |
| FI (1) | FI792780A (es) |
| FR (1) | FR2435462A1 (es) |
| GB (1) | GB2030984B (es) |
| GR (1) | GR72494B (es) |
| IL (1) | IL58200A (es) |
| IT (1) | IT1120561B (es) |
| NL (1) | NL7906745A (es) |
| NO (1) | NO792901L (es) |
| NZ (1) | NZ191505A (es) |
| PT (1) | PT70151B (es) |
| SE (1) | SE7907432L (es) |
| ZA (1) | ZA794764B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5097035A (en) * | 1984-07-09 | 1992-03-17 | G. D. Searle & Co. | Monobasic disobutamide derivatives |
| US4639524A (en) * | 1984-07-09 | 1987-01-27 | G. D. Searle & Co. | Monobasic disobutamide derivatives |
| US4791199A (en) * | 1985-09-19 | 1988-12-13 | G. D. Searle & Co. | Process for antiarrhythmic 1,3-diazabicyclo[4.4.0]dec-2-en-4-ones |
| EP0370712A3 (en) * | 1988-11-18 | 1991-10-02 | Ajinomoto Co., Inc. | Ethylamine derivatives and hypotensives containing the same |
| FR2686339B1 (fr) * | 1992-01-22 | 1994-03-11 | Adir Cie | Nouveaux amides et sulfonamides naphtaleniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5432284A (en) * | 1993-09-08 | 1995-07-11 | G. D. Searle & Co. | Process for the preparation of heterocyclic alkylamide derivatives |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2884436A (en) * | 1954-08-28 | 1959-04-28 | Nl Combinatie Chem Ind | Parasympathicolytically active alpha, alpha-diphenyl-gamma-dialkylaminobutyramide compounds and manufacture thereof |
| US3022314A (en) * | 1955-06-20 | 1962-02-20 | Upjohn Co | Alpha-phenyl-omega-amino-alkanamides |
| US3022302A (en) * | 1956-03-15 | 1962-02-20 | Pharmacia Ab | Manufacture of nu, nu-disubstituted amides of aryl acetic acids |
| US3078275A (en) * | 1956-05-28 | 1963-02-19 | Upjohn Co | N, n-disubstituted-alpha-(tertiaryaminoalkyl)-alpha, alpha-diphenylacetamides |
| US2894955A (en) * | 1956-11-19 | 1959-07-14 | Upjohn Co | Organic compounds |
| US3225091A (en) * | 1962-02-01 | 1965-12-21 | Lilly Co Eli | Anticholinergic substituted butyramides |
| NL124729C (es) * | 1963-05-14 | |||
| US4107205A (en) * | 1977-03-11 | 1978-08-15 | G. D. Searle & Co. | α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]acetamides and related compounds |
-
1978
- 1978-09-08 US US05/940,527 patent/US4217306A/en not_active Expired - Lifetime
-
1979
- 1979-09-07 AU AU50686/79A patent/AU5068679A/en not_active Abandoned
- 1979-09-07 GR GR59993A patent/GR72494B/el unknown
- 1979-09-07 DK DK374879A patent/DK374879A/da not_active Application Discontinuation
- 1979-09-07 GB GB7931218A patent/GB2030984B/en not_active Expired
- 1979-09-07 AT AT0592679A patent/AT364813B/de not_active IP Right Cessation
- 1979-09-07 FI FI792780A patent/FI792780A/fi not_active Application Discontinuation
- 1979-09-07 BE BE0/197051A patent/BE878662A/fr unknown
- 1979-09-07 NO NO792901A patent/NO792901L/no unknown
- 1979-09-07 JP JP11508979A patent/JPS5592350A/ja active Pending
- 1979-09-07 ZA ZA00794764A patent/ZA794764B/xx unknown
- 1979-09-07 FR FR7922468A patent/FR2435462A1/fr active Pending
- 1979-09-07 SE SE7907432A patent/SE7907432L/xx not_active Application Discontinuation
- 1979-09-07 IT IT50202/79A patent/IT1120561B/it active
- 1979-09-07 PT PT70151A patent/PT70151B/pt unknown
- 1979-09-07 CA CA000335200A patent/CA1136622A/en not_active Expired
- 1979-09-07 ES ES483985A patent/ES483985A1/es not_active Expired
- 1979-09-07 NZ NZ191505A patent/NZ191505A/xx unknown
- 1979-09-07 IL IL58200A patent/IL58200A/xx unknown
- 1979-09-07 DE DE19792936287 patent/DE2936287A1/de not_active Withdrawn
- 1979-09-10 NL NL7906745A patent/NL7906745A/nl not_active Application Discontinuation
-
1980
- 1980-12-10 AT AT0600280A patent/AT370088B/de not_active IP Right Cessation
- 1980-12-10 AT AT0600180A patent/AT370087B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATA600180A (de) | 1982-07-15 |
| CA1136622A (en) | 1982-11-30 |
| IL58200A0 (en) | 1979-12-30 |
| DE2936287A1 (de) | 1980-03-20 |
| GB2030984A (en) | 1980-04-16 |
| ZA794764B (en) | 1981-04-29 |
| FR2435462A1 (fr) | 1980-04-04 |
| NZ191505A (en) | 1982-03-30 |
| FI792780A (fi) | 1980-03-09 |
| GB2030984B (en) | 1983-07-27 |
| AT370087B (de) | 1983-02-25 |
| JPS5592350A (en) | 1980-07-12 |
| IT7950202A0 (it) | 1979-09-07 |
| NL7906745A (nl) | 1980-03-11 |
| ATA600280A (de) | 1982-07-15 |
| NO792901L (no) | 1980-03-11 |
| PT70151B (pt) | 1981-12-11 |
| US4217306A (en) | 1980-08-12 |
| AU5068679A (en) | 1980-03-27 |
| IL58200A (en) | 1982-12-31 |
| IT1120561B (it) | 1986-03-26 |
| DK374879A (da) | 1980-03-09 |
| AT370088B (de) | 1983-02-25 |
| BE878662A (fr) | 1980-03-07 |
| SE7907432L (sv) | 1980-03-09 |
| AT364813B (de) | 1981-11-25 |
| PT70151A (en) | 1979-09-01 |
| ATA592679A (de) | 1981-04-15 |
| GR72494B (es) | 1983-11-15 |
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