ES2052783T3 - Procedimiento para la preparacion de 4-alquil-1,4-dihidropiridinas. - Google Patents

Procedimiento para la preparacion de 4-alquil-1,4-dihidropiridinas.

Info

Publication number
ES2052783T3
ES2052783T3 ES89100656T ES89100656T ES2052783T3 ES 2052783 T3 ES2052783 T3 ES 2052783T3 ES 89100656 T ES89100656 T ES 89100656T ES 89100656 T ES89100656 T ES 89100656T ES 2052783 T3 ES2052783 T3 ES 2052783T3
Authority
ES
Spain
Prior art keywords
reaction
vii
dihydropyridines
alkyl
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89100656T
Other languages
English (en)
Inventor
Carlos Sunkel
De Casa-Juana Miguel Fau
Luis Santos
Pilar Ortega
Jaime Priego
Mariano Sanchez-Crespo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alter SA
Original Assignee
Alter SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alter SA filed Critical Alter SA
Application granted granted Critical
Publication of ES2052783T3 publication Critical patent/ES2052783T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

SE DESCRIBEN LOS 4 - ALQUILO - 1,4 - DIHIDROPIRIDINAS, CON ACTIVIDAD PAF - ANTAGONISTA, DE LA FORMULA(I) DONDE R ES C1 - 4 SATURADO, R''ES ALQUILO C1 - 6 SATURADO, QUE PUEDE SER INTERRUMPIDO POR UN ATOMO DE OXIGENO, O TETRAHIDROFURFURILO Y R2 ES C1 - 4 SATURADO O FENILO. EL COMPUESTO DONDE R ES METILO, R''ES ETILO Y R2 ES FENILO QUE PERMANECE EXCLUIDO. LOS COMPUESTOS (I) SE PREPARAN POR (A) REACCION DE (II) CON (III); (B) REACCION DE (IV) CON (V); (C) REACCION DE (VI) CON (III) Y CON (VII); (D) REACCION DE (VIII) CON (V) Y CON (VII); O (E) REACCION DE (VIII) CON (VI) Y CON (VII) EN PRESENCIA DE AMONIO. LOS COMPUESTOS (I) SON UTILES DEBIDO A SU ACTIVIDAD ANTAGONISTA DE ACTIVACION DEL FACTOR PLAQUETARIO.
ES89100656T 1988-01-21 1989-01-16 Procedimiento para la preparacion de 4-alquil-1,4-dihidropiridinas. Expired - Lifetime ES2052783T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3801717A DE3801717C1 (es) 1988-01-21 1988-01-21
EP91500103A EP0531598A1 (en) 1988-01-21 1991-09-09 1,4-Dihydropyridines with paf-antagonistic activity

Publications (1)

Publication Number Publication Date
ES2052783T3 true ES2052783T3 (es) 1994-07-16

Family

ID=40279084

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89100656T Expired - Lifetime ES2052783T3 (es) 1988-01-21 1989-01-16 Procedimiento para la preparacion de 4-alquil-1,4-dihidropiridinas.

Country Status (19)

Country Link
EP (2) EP0325187B1 (es)
JP (2) JPH01233273A (es)
KR (1) KR910008348B1 (es)
AR (1) AR248137A1 (es)
BR (1) BR9203580A (es)
CA (2) CA1332838C (es)
CZ (1) CZ278692A3 (es)
DE (1) DE3801717C1 (es)
DK (1) DK25989A (es)
ES (1) ES2052783T3 (es)
FI (1) FI924018A (es)
GR (1) GR3006934T3 (es)
HU (1) HUT65253A (es)
IE (2) IE890136L (es)
MX (1) MX9204642A (es)
NO (1) NO923489L (es)
PL (1) PL295861A1 (es)
PT (2) PT89494B (es)
ZA (2) ZA89519B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3801717C1 (es) * 1988-01-21 1989-05-24 Alter S.A., Madrid, Es
US5843950A (en) * 1994-07-29 1998-12-01 Nikken Chemicals Co., Ltd. 1,4-dihydropyridine compound and pharmaceutical composition containing the same
AU1224599A (en) * 1997-11-14 1999-06-07 Neurosearch A/S Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction
US6566359B1 (en) 2002-05-20 2003-05-20 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College 2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid esters as neuroprotective drugs
WO2016144995A1 (en) * 2015-03-09 2016-09-15 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods for the treatment of glioblastoma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2747513A1 (de) * 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen
US4761420A (en) * 1986-06-13 1988-08-02 Laboratoires Syntex S.A. Antihypertensive dihydropyridine derivatives
DE3801717C1 (es) * 1988-01-21 1989-05-24 Alter S.A., Madrid, Es

Also Published As

Publication number Publication date
DK25989A (da) 1989-07-22
IE890136L (en) 1989-07-21
JPH01233273A (ja) 1989-09-19
HU9202873D0 (en) 1992-11-30
JPH05208958A (ja) 1993-08-20
CZ278692A3 (en) 1993-12-15
PT100848A (pt) 1993-10-29
EP0531598A1 (en) 1993-03-17
EP0325187A1 (en) 1989-07-26
DK25989D0 (da) 1989-01-20
NO923489D0 (no) 1992-09-08
JPH0552827B2 (es) 1993-08-06
IE922412A1 (en) 1993-03-10
DE3801717C1 (es) 1989-05-24
ZA89519B (en) 1989-10-25
AR248137A1 (es) 1995-06-30
MX9204642A (es) 1993-12-01
PL295861A1 (en) 1993-05-04
HUT65253A (en) 1994-05-02
PT89494A (pt) 1989-10-04
GR3006934T3 (es) 1993-06-30
PT89494B (pt) 1994-03-31
NO923489L (no) 1993-03-10
CA2074419A1 (en) 1993-03-10
FI924018A (fi) 1993-03-10
KR910008348B1 (ko) 1991-10-12
ZA925692B (en) 1993-03-02
JPH0742271B2 (ja) 1995-05-10
FI924018A0 (fi) 1992-09-08
KR890011842A (ko) 1989-08-22
EP0325187B1 (en) 1992-11-11
BR9203580A (pt) 1993-04-13
CA1332838C (en) 1994-11-01

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