ES2083464T3 - Compuestos heterociclicos. - Google Patents

Compuestos heterociclicos.

Info

Publication number
ES2083464T3
ES2083464T3 ES90915801T ES90915801T ES2083464T3 ES 2083464 T3 ES2083464 T3 ES 2083464T3 ES 90915801 T ES90915801 T ES 90915801T ES 90915801 T ES90915801 T ES 90915801T ES 2083464 T3 ES2083464 T3 ES 2083464T3
Authority
ES
Spain
Prior art keywords
elevated
cyclic compounds
hetero cyclic
hydrogen
square
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90915801T
Other languages
English (en)
Inventor
Terence James Ward
Janet Christine White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898923209A external-priority patent/GB8923209D0/en
Priority claimed from GB909010085A external-priority patent/GB9010085D0/en
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Application granted granted Critical
Publication of ES2083464T3 publication Critical patent/ES2083464T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Earth Drilling (AREA)
  • Stereophonic System (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

COMPUESTOS DE LA FORMULA (I) DONDE R ELEVADO 1 ES HIDROGENO O UNO O MAS SUSTITUYENTES ESPECIFICOS, X ES -O UADRADO) ICO DE ALQUILO INFERIOR O R (AL CUADRADO) REPRESENTA UN GRUPO -ZRA FORMAR UN ANILLO HETEROCICLICO DE 5 A 7 MIEMBROS, Y ES O O NR ELEVADO 3 DONDE R ELEVADO 3 ES HIDROGENO O ALQUILO INFERIOR Y B ES UN ANILLO ASABICICLICO SATURADO (POR EJ., TROPANILO O QUINUCLINIDILO) O UNO DE SUS OXIDOS -N Y SUS SALES DE ADICION ACIDA SON ANTAGONISTAS 5-HT SUB 3 QUE SE PUEDEN USAR, POR EJEMPLO, EN EL TRATAMIENTO DE ENFERMEDADES NEURO-PSIQUIATRICAS.
ES90915801T 1989-10-14 1990-10-10 Compuestos heterociclicos. Expired - Lifetime ES2083464T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898923209A GB8923209D0 (en) 1989-10-14 1989-10-14 Heterocyclic compounds
GB909010085A GB9010085D0 (en) 1990-05-04 1990-05-04 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ES2083464T3 true ES2083464T3 (es) 1996-04-16

Family

ID=26296055

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90915801T Expired - Lifetime ES2083464T3 (es) 1989-10-14 1990-10-10 Compuestos heterociclicos.

Country Status (16)

Country Link
US (2) US5096901A (es)
EP (1) EP0494978B1 (es)
JP (1) JPH05501255A (es)
KR (1) KR0154316B1 (es)
AT (1) ATE134631T1 (es)
AU (1) AU636179B2 (es)
CA (1) CA2066640C (es)
DE (1) DE69025621T2 (es)
DK (1) DK0494978T3 (es)
ES (1) ES2083464T3 (es)
FI (1) FI921560L (es)
GB (1) GB2236751B (es)
GR (1) GR3019527T3 (es)
IE (1) IE64455B1 (es)
PT (1) PT95583B (es)
WO (1) WO1991005783A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2236751B (en) * 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
JP3122671B2 (ja) * 1990-05-23 2001-01-09 協和醗酵工業株式会社 複素環式化合物
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
JP2699794B2 (ja) * 1992-03-12 1998-01-19 三菱化学株式会社 チエノ〔３，２−ｂ〕ピリジン誘導体
FR2694005B1 (fr) * 1992-07-21 1994-08-26 Adir Nouvelles aminoalkylchromones, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
GB9314174D0 (en) * 1993-07-08 1993-08-18 American Home Prod 5-ht3-antagonists
US5663182A (en) * 1993-08-19 1997-09-02 Bymaster; Franklin Porter Antipsychotic method
DE4424369A1 (de) * 1994-07-11 1996-01-18 Bayer Ag Pyrido[3,2,1.i,j][3,1]benzoxazinderivate
US5749111A (en) 1996-02-14 1998-05-12 Teksource, Lc Gelatinous cushions with buckling columns
US5792774A (en) * 1996-02-21 1998-08-11 Chiroscience Limited Quinolones and their therapeutic use
PE20011349A1 (es) 2000-06-16 2002-01-19 Upjohn Co 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales
US6525049B2 (en) 2000-07-05 2003-02-25 Pharmacia & Upjohn Company Pyrroloquinolones as antiviral agents
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
AR036041A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
BR0212477A (pt) * 2001-09-12 2004-08-24 Upjohn Co 7-aza[2.2.1] bicicloheptanos substituìdos para o tratamento de doenças
WO2003042210A1 (en) 2001-11-09 2003-05-22 Pharmacia & Upjohn Company Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands
JP2006506395A (ja) * 2002-11-01 2006-02-23 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ＣＮＳ疾患の治療のための、α７ニコチンアゴニスト活性及び５ＨＴ３アンタゴニスト活性を有する化合物
MX341797B (es) 2004-06-24 2016-09-02 Vertex Pharmaceuticals Incorporated * Moduladores de transportadores con casete de union con atp.
ES2332808T3 (es) * 2004-11-05 2010-02-12 Theravance, Inc. Compuestos agonistas del receptor 5-ht4.
EP1807423B1 (en) * 2004-11-05 2009-05-20 Theravance, Inc. Quinolinone-carboxamide compounds
LT1993360T (lt) 2005-12-28 2017-06-12 Vertex Pharmaceuticals Incorporated N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
JP2010208947A (ja) * 2007-06-29 2010-09-24 Dainippon Sumitomo Pharma Co Ltd キノロン誘導体
US8075981B2 (en) 2007-08-23 2011-12-13 Edizone, Llc Alternating pattern gel cushioning elements and related methods
US8697722B2 (en) * 2007-11-02 2014-04-15 Sri International Nicotinic acetylcholine receptor modulators
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
HUE038854T2 (hu) 2009-03-20 2018-12-28 Vertex Pharma Cisztás fibrózis transzmembrán konduktancia regulátor modulátorai
MX384179B (es) 2009-03-20 2025-03-14 Vertex Pharma Proceso para producir moduladores del regulador de conductancia transmembrana de fibrosis quística.
WO2011085389A1 (en) * 2010-01-11 2011-07-14 Astraea Therapeutics, Llc Nicotinic acetylcholine receptor modulators
JP2015511583A (ja) 2012-02-27 2015-04-20 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 薬学的組成物およびその投与
EP2821401B1 (en) 2012-03-02 2020-09-09 Takeda Pharmaceutical Company Limited Dihydroquinolinone compounds as modulators of the muscarininc m1 receptor
EP2921480B1 (en) 2012-11-19 2017-10-11 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound
EP3723762A4 (en) 2017-12-13 2021-12-08 Praxis Biotech LLC STRESS INTEGRATED RESPONSE PATH INHIBITORS
BR112020023115A2 (pt) 2018-06-05 2021-02-02 Praxis Biotech LLC inibidores da via integrada de resposta a tensão
CA3142748A1 (en) * 2019-06-12 2020-12-17 Praxis Biotech LLC Modulators of integrated stress response pathway

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531083B1 (fr) 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
EP0113781A4 (en) * 1982-07-09 1986-05-14 Thompson Boyce Plant Res Genetic engineering in procaryotic organism.
EP0135545A1 (en) * 1983-02-19 1985-04-03 Beecham Group Plc Azabicycloalkyl benzamide and anilide derivatives
WO1985001048A1 (en) * 1983-08-26 1985-03-14 Sandoz Ag Aromatic esters or amides of carboxylic acid and sulfonic acid
SE460359B (sv) 1984-01-25 1989-10-02 Glaxo Group Ltd 3-imidazolylmetyltetrahydrokarbazoloner, foerfarande foer framstaellning av dessa och en farmaceutisk komposition
DE3687080T2 (de) 1985-04-27 1993-03-25 Beecham Group Plc Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung.
DE3827253A1 (de) * 1987-08-20 1989-03-02 Sandoz Ag Ester und amide von cyclischen carbonsaeuren und cyclischen alkoholen und aminen sowie verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
IE63474B1 (en) 1987-12-24 1995-04-19 Wyeth John & Brother Ltd Heterocyclic compounds
IT1228293B (it) * 1989-02-06 1991-06-07 Angeli Inst Spa Benzoderivati di composti eterociclici contenenti azoto.
GB2236751B (en) * 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
US5225419A (en) * 1989-10-14 1993-07-06 John Wyeth & Brother, Limited Certain 1,8-ethano or propano-1,4-dihydro-4-oxo-quinoline-3-carboxamides and derivatives thereof

Also Published As

Publication number Publication date
FI921560A7 (fi) 1992-04-08
DE69025621D1 (de) 1996-04-04
FI921560A0 (fi) 1992-04-08
FI921560L (fi) 1992-04-08
WO1991005783A1 (en) 1991-05-02
GR3019527T3 (en) 1996-07-31
GB9021697D0 (en) 1990-11-21
KR0154316B1 (ko) 1998-11-16
IE64455B1 (en) 1995-08-09
AU6621090A (en) 1991-05-16
PT95583B (pt) 1997-08-29
AU636179B2 (en) 1993-04-22
KR927003585A (ko) 1992-12-18
GB2236751B (en) 1993-04-28
US5096901A (en) 1992-03-17
EP0494978A1 (en) 1992-07-22
US5362734A (en) 1994-11-08
JPH05501255A (ja) 1993-03-11
CA2066640A1 (en) 1991-04-15
PT95583A (pt) 1991-09-13
ATE134631T1 (de) 1996-03-15
DE69025621T2 (de) 1996-07-04
GB2236751A (en) 1991-04-17
EP0494978B1 (en) 1996-02-28
CA2066640C (en) 2000-08-01
IE903617A1 (en) 1991-04-24
DK0494978T3 (da) 1996-03-18

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