MX384179B - Proceso para producir moduladores del regulador de conductancia transmembrana de fibrosis quística. - Google Patents

Proceso para producir moduladores del regulador de conductancia transmembrana de fibrosis quística.

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Publication number
MX384179B
MX384179B MX2018015576A MX2018015576A MX384179B MX 384179 B MX384179 B MX 384179B MX 2018015576 A MX2018015576 A MX 2018015576A MX 2018015576 A MX2018015576 A MX 2018015576A MX 384179 B MX384179 B MX 384179B
Authority
MX
Mexico
Prior art keywords
cystic fibrosis
fibrosis transmembrane
conductance regulator
transmembrane conductance
formula
Prior art date
Application number
MX2018015576A
Other languages
English (en)
Inventor
Adam R Looker
Bobbianna Neubert-Langille
Brian R Krueger
Dahrika Milfred Lao Yap
Goor Fredrick F Van
Gregor Zlokarnik
John Demattei
Martin Trudeau
Martyn C Botfield
Michael P Ryan
Peter D J Grootenhuis
Stefanie Roeper
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX384179B publication Critical patent/MX384179B/es

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    • C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
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Abstract

La invención proporciona un proceso para la preparación de un compuesto de la Fórmula 1 (ver Fórmula) que comprende acoplar un ácido carboxílico de la Fórmula 2 (ver Fórmula) con una anilina de la Fórmula 3 (ver Fórmula) en presencia de un agente de acoplamiento.
MX2018015576A 2009-03-20 2010-03-19 Proceso para producir moduladores del regulador de conductancia transmembrana de fibrosis quística. MX384179B (es)

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PCT/US2010/028069 WO2010108162A1 (en) 2009-03-20 2010-03-19 Process for making modulators of cystic fibrosis transmembrane conductance regulator

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US8835639B2 (en) 2014-09-16
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