PL2821400T3 - Sposób wytwarzania modulatorów regulatora przewodności przezbłonowej zwłóknienia torbielowatego - Google Patents
Sposób wytwarzania modulatorów regulatora przewodności przezbłonowej zwłóknienia torbielowategoInfo
- Publication number
- PL2821400T3 PL2821400T3 PL14182117T PL14182117T PL2821400T3 PL 2821400 T3 PL2821400 T3 PL 2821400T3 PL 14182117 T PL14182117 T PL 14182117T PL 14182117 T PL14182117 T PL 14182117T PL 2821400 T3 PL2821400 T3 PL 2821400T3
- Authority
- PL
- Poland
- Prior art keywords
- cystic fibrosis
- fibrosis transmembrane
- conductance regulator
- transmembrane conductance
- modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16214809P | 2009-03-20 | 2009-03-20 | |
US24630309P | 2009-09-28 | 2009-09-28 | |
US24856509P | 2009-10-05 | 2009-10-05 | |
EP10710749.2A EP2408750B1 (en) | 2009-03-20 | 2010-03-19 | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
EP14182117.3A EP2821400B1 (en) | 2009-03-20 | 2010-03-19 | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
Publications (1)
Publication Number | Publication Date |
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PL2821400T3 true PL2821400T3 (pl) | 2018-04-30 |
Family
ID=42140035
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL10710749T PL2408750T3 (pl) | 2009-03-20 | 2010-03-19 | Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy |
PL14182117T PL2821400T3 (pl) | 2009-03-20 | 2010-03-19 | Sposób wytwarzania modulatorów regulatora przewodności przezbłonowej zwłóknienia torbielowatego |
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TWI730959B (zh) | 2015-05-19 | 2021-06-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺 |
CA3021752A1 (en) | 2015-06-11 | 2016-12-15 | Aizant Drug Research Solutions Private Limited | Nanoparticulate ivacaftor formulations |
CN105884628B (zh) | 2016-06-06 | 2018-06-29 | 上海工程技术大学 | 2,4-二叔丁基-5-氨基酚的制备方法 |
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