PL2821400T3 - Sposób wytwarzania modulatorów regulatora przewodności przezbłonowej zwłóknienia torbielowatego - Google Patents

Sposób wytwarzania modulatorów regulatora przewodności przezbłonowej zwłóknienia torbielowatego

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Publication number
PL2821400T3
PL2821400T3 PL14182117T PL14182117T PL2821400T3 PL 2821400 T3 PL2821400 T3 PL 2821400T3 PL 14182117 T PL14182117 T PL 14182117T PL 14182117 T PL14182117 T PL 14182117T PL 2821400 T3 PL2821400 T3 PL 2821400T3
Authority
PL
Poland
Prior art keywords
cystic fibrosis
fibrosis transmembrane
conductance regulator
transmembrane conductance
modulators
Prior art date
Application number
PL14182117T
Other languages
English (en)
Inventor
John Demattei
Adam R. Looker
Bobbiana Neubert-Langille
Martin Trudeau
Stefanie Roper
Michael Ryan
Dahrika Milfred Lao Yap
Brian R. Krueger
Peter D.J. Grootenhuis
Frederick F. Van Groor
Martyn C. Botfield
Gregor Zlokarnik
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of PL2821400T3 publication Critical patent/PL2821400T3/pl

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    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
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    • C07C205/42Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/43Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
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    • G01N33/5041Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
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    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
PL14182117T 2009-03-20 2010-03-19 Sposób wytwarzania modulatorów regulatora przewodności przezbłonowej zwłóknienia torbielowatego PL2821400T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16214809P 2009-03-20 2009-03-20
US24630309P 2009-09-28 2009-09-28
US24856509P 2009-10-05 2009-10-05
EP10710749.2A EP2408750B1 (en) 2009-03-20 2010-03-19 Process for making modulators of cystic fibrosis transmembrane conductance regulator
EP14182117.3A EP2821400B1 (en) 2009-03-20 2010-03-19 Process for making modulators of cystic fibrosis transmembrane conductance regulator

Publications (1)

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PL2821400T3 true PL2821400T3 (pl) 2018-04-30

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Application Number Title Priority Date Filing Date
PL10710749T PL2408750T3 (pl) 2009-03-20 2010-03-19 Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy
PL14182117T PL2821400T3 (pl) 2009-03-20 2010-03-19 Sposób wytwarzania modulatorów regulatora przewodności przezbłonowej zwłóknienia torbielowatego

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