FR2720397B1 - Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment. - Google Patents

Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment.

Info

Publication number
FR2720397B1
FR2720397B1 FR9406262A FR9406262A FR2720397B1 FR 2720397 B1 FR2720397 B1 FR 2720397B1 FR 9406262 A FR9406262 A FR 9406262A FR 9406262 A FR9406262 A FR 9406262A FR 2720397 B1 FR2720397 B1 FR 2720397B1
Authority
FR
France
Prior art keywords
oxathiolanes
preparation
new
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9406262A
Other languages
English (en)
Other versions
FR2720397A1 (fr
Inventor
Anne-Sophie Charvet-Faury
Michel Camplo
Jean-Louis Kraus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LAPHAL LABORATOIRES SA
Original Assignee
LAPHAL LABORATOIRES SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9406262A priority Critical patent/FR2720397B1/fr
Application filed by LAPHAL LABORATOIRES SA filed Critical LAPHAL LABORATOIRES SA
Priority to JP7530108A priority patent/JPH09502453A/ja
Priority to RU96105063A priority patent/RU2142462C1/ru
Priority to BR9506244A priority patent/BR9506244A/pt
Priority to CN95190647A priority patent/CN1080264C/zh
Priority to KR1019960700446A priority patent/KR100242891B1/ko
Priority to CZ96219A priority patent/CZ21996A3/cs
Priority to FI960316A priority patent/FI960316A7/fi
Priority to US08/586,892 priority patent/US5708000A/en
Priority to EP95920986A priority patent/EP0733053A1/fr
Priority to AU26209/95A priority patent/AU688052B2/en
Priority to PL95312693A priority patent/PL181713B1/pl
Priority to HU9600155A priority patent/HU219299B/hu
Priority to PCT/FR1995/000683 priority patent/WO1995032200A1/fr
Priority to CA002167930A priority patent/CA2167930A1/fr
Priority to NZ287478A priority patent/NZ287478A/en
Publication of FR2720397A1 publication Critical patent/FR2720397A1/fr
Priority to NO960272A priority patent/NO306299B1/no
Priority to APAP/P/1996/000784A priority patent/AP612A/en
Priority to OA60770A priority patent/OA10258A/fr
Application granted granted Critical
Publication of FR2720397B1 publication Critical patent/FR2720397B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR9406262A 1994-05-24 1994-05-24 Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment. Expired - Fee Related FR2720397B1 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR9406262A FR2720397B1 (fr) 1994-05-24 1994-05-24 Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment.
PL95312693A PL181713B1 (en) 1994-05-24 1995-05-24 Oxathiolanes, method of their production and pharmaceutical compounds containing them
BR9506244A BR9506244A (pt) 1994-05-24 1995-05-24 5-(Citosinil-1)1,3-oxatiolanos de configuração cis (2r-5r)compostos nicotínicos compostos dihidropirídicos compostos nicotínicos quaternizados compostos quinolênicos compostos dihidroquinoleinila compostos quinoleinilas quaternizados compsotos (dihidropiridil alquila)sais de adição com ácido orgânico ou mineral isômeros oticamente ativos dos compostos processo para a produção de compostos e composições farmacêuticas com ação antiviral
CN95190647A CN1080264C (zh) 1994-05-24 1995-05-24 氧硫杂环戊烷、其制备方法和含此类化合物的药物组合物
KR1019960700446A KR100242891B1 (ko) 1994-05-24 1995-05-24 옥사티올란, 이것의 제조방법 및 이것을 함유하는 제약조성물(oxathiolanes, method for their preparation and pharmaceutical compositions containing same)
CZ96219A CZ21996A3 (en) 1994-05-24 1995-05-24 Oxathiolates, process of their preparation and pharmaceutical compositions containing thereof
FI960316A FI960316A7 (fi) 1994-05-24 1995-05-24 Oksatiolaanit, menetelmä niiden valmistamiseksi ja niitä sisältävät fa rmaseuttiset koostumukset
PCT/FR1995/000683 WO1995032200A1 (fr) 1994-05-24 1995-05-24 Oxathiolanes, leur procede de preparation et les compositions pharmaceutiques qui en renferment
RU96105063A RU2142462C1 (ru) 1994-05-24 1995-05-24 5-(цитозинил-1-)-1,3-оксатиоланы, способ их получения и фармацевтическая композиция
AU26209/95A AU688052B2 (en) 1994-05-24 1995-05-24 Oxathiolanes, method for their preparation and pharmaceutical compositions containing same
JP7530108A JPH09502453A (ja) 1994-05-24 1995-05-24 オキサチオランと、その製造方法と、それを含む医薬組成物
EP95920986A EP0733053A1 (fr) 1994-05-24 1995-05-24 Oxathiolanes, leur procede de preparation et les compositions pharmaceutiques qui en renferment
US08/586,892 US5708000A (en) 1994-05-24 1995-05-24 N4-substituted cytosinyl 1,3-oxathiolane nucleoside analogues, and their antiviral activity
CA002167930A CA2167930A1 (fr) 1994-05-24 1995-05-24 Oxathiolanes, leur procede de preparation et les compositions pharmaceutiques qui en renferment
HU9600155A HU219299B (en) 1994-05-24 1995-05-24 Oxathiolanes, method for their preparation and pharmaceutical compositions contating same
NZ287478A NZ287478A (en) 1994-05-24 1995-05-25 Oxathiolanes; compounds, preparation and pharmaceutical compositions
NO960272A NO306299B1 (no) 1994-05-24 1996-01-23 Oksatiolaner og farmasöytiske preparater med antiviral virkning som inneholder de samme
APAP/P/1996/000784A AP612A (en) 1994-05-24 1996-01-23 Oxathiolanes, method for their preparation and pharmaceutical compositions containing same.
OA60770A OA10258A (fr) 1994-05-24 1996-01-24 Oxathiolanes leur procédé de préparation et les compositions pharmaceutiques qui en referment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9406262A FR2720397B1 (fr) 1994-05-24 1994-05-24 Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment.

Publications (2)

Publication Number Publication Date
FR2720397A1 FR2720397A1 (fr) 1995-12-01
FR2720397B1 true FR2720397B1 (fr) 1996-08-23

Family

ID=9463449

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9406262A Expired - Fee Related FR2720397B1 (fr) 1994-05-24 1994-05-24 Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment.

Country Status (19)

Country Link
US (1) US5708000A (fr)
EP (1) EP0733053A1 (fr)
JP (1) JPH09502453A (fr)
KR (1) KR100242891B1 (fr)
CN (1) CN1080264C (fr)
AP (1) AP612A (fr)
AU (1) AU688052B2 (fr)
BR (1) BR9506244A (fr)
CA (1) CA2167930A1 (fr)
CZ (1) CZ21996A3 (fr)
FI (1) FI960316A7 (fr)
FR (1) FR2720397B1 (fr)
HU (1) HU219299B (fr)
NO (1) NO306299B1 (fr)
NZ (1) NZ287478A (fr)
OA (1) OA10258A (fr)
PL (1) PL181713B1 (fr)
RU (1) RU2142462C1 (fr)
WO (1) WO1995032200A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2720397B1 (fr) * 1994-05-24 1996-08-23 Laphal Laboratoires Sa Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment.
IT1290447B1 (it) 1997-03-28 1998-12-03 Zambon Spa Derivati 1,3-ossatiolanici ad attivita' antivirale
US8354427B2 (en) * 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
MX341797B (es) * 2004-06-24 2016-09-02 Vertex Pharmaceuticals Incorporated * Moduladores de transportadores con casete de union con atp.
EP1979367A2 (fr) * 2005-12-24 2008-10-15 Vertex Pharmaceuticals Incorporated Derives de quinoline-4-one comme modulateurs de transporteurs abc
LT1993360T (lt) * 2005-12-28 2017-06-12 Vertex Pharmaceuticals Incorporated N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
PE20071025A1 (es) * 2006-01-31 2007-10-17 Mitsubishi Tanabe Pharma Corp Compuesto amina trisustituido
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
MX384179B (es) 2009-03-20 2025-03-14 Vertex Pharma Proceso para producir moduladores del regulador de conductancia transmembrana de fibrosis quística.
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
JP2015511583A (ja) 2012-02-27 2015-04-20 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 薬学的組成物およびその投与
EP3204358B1 (fr) 2014-10-07 2018-09-19 Vertex Pharmaceuticals Incorporated Co-cristaux de modulateurs du régulateur de conductance transmembranaire de la mucoviscidose

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
JP2960164B2 (ja) * 1990-11-13 1999-10-06 バイオケム ファーマ インコーポレイテッド 抗ウイルス特性を有する置換１，３−オキサチオラン類および置換１，３−ジチオラン類
IL100965A (en) * 1991-02-22 1999-12-31 Univ Emory 2-Hydroxymethyl-5-(5-fluorocytosin-l-yl)-1,3-oxathiolane its resolution and pharmaceutical compositions containing it
DK0513917T4 (da) * 1991-05-16 2001-06-25 Glaxo Group Ltd Antivirale kombinationer indeholdende nukleosidanaloger
GB9110874D0 (en) * 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
FR2720397B1 (fr) * 1994-05-24 1996-08-23 Laphal Laboratoires Sa Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment.

Also Published As

Publication number Publication date
FI960316A0 (fi) 1996-01-23
KR100242891B1 (ko) 2000-03-02
RU2142462C1 (ru) 1999-12-10
KR960703903A (ko) 1996-08-31
US5708000A (en) 1998-01-13
CA2167930A1 (fr) 1995-11-30
AU688052B2 (en) 1998-03-05
HU219299B (en) 2001-03-28
OA10258A (fr) 1997-10-07
EP0733053A1 (fr) 1996-09-25
BR9506244A (pt) 1997-08-12
NZ287478A (en) 1997-09-22
AP9600784A0 (en) 1996-04-30
NO306299B1 (no) 1999-10-18
FR2720397A1 (fr) 1995-12-01
AU2620995A (en) 1995-12-18
NO960272L (no) 1996-01-23
FI960316L (fi) 1996-03-22
CN1130906A (zh) 1996-09-11
FI960316A7 (fi) 1996-03-22
PL312693A1 (en) 1996-05-13
PL181713B1 (en) 2001-09-28
AP612A (en) 1997-09-05
HUT75112A (en) 1997-04-28
WO1995032200A1 (fr) 1995-11-30
CN1080264C (zh) 2002-03-06
CZ21996A3 (en) 1996-05-15
JPH09502453A (ja) 1997-03-11
NO960272D0 (no) 1996-01-23

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Legal Events

Date Code Title Description
ST Notification of lapse