DZ2045A1 - Amides thérapeutiques, procédé pour leur préparation et compositions les contenant. - Google Patents
Amides thérapeutiques, procédé pour leur préparation et compositions les contenant.Info
- Publication number
- DZ2045A1 DZ2045A1 DZ960089A DZ960089A DZ2045A1 DZ 2045 A1 DZ2045 A1 DZ 2045A1 DZ 960089 A DZ960089 A DZ 960089A DZ 960089 A DZ960089 A DZ 960089A DZ 2045 A1 DZ2045 A1 DZ 2045A1
- Authority
- DZ
- Algeria
- Prior art keywords
- preparation
- compositions containing
- amides
- therapeutic amides
- therapeutic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB1995/000448 WO1996040640A1 (fr) | 1995-06-07 | 1995-06-07 | DERIVES DE BIPHENYL-2-ACIDE CARBOXYLIQUE-TETRAHYDRO-ISOQUINOLEINE-6-YL AMIDES, PREPARATION DE CES AMIDES ET UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE TRIGLYCERIDE MICROSOMAL ET/OU DE LA SECRETION D'APOLIPOPROTEINES B (Apo B) |
Publications (1)
Publication Number | Publication Date |
---|---|
DZ2045A1 true DZ2045A1 (fr) | 2002-07-21 |
Family
ID=11004342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DZ960089A DZ2045A1 (fr) | 1995-06-07 | 1996-06-05 | Amides thérapeutiques, procédé pour leur préparation et compositions les contenant. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5919795A (fr) |
KR (1) | KR100225713B1 (fr) |
AR (1) | AR003424A1 (fr) |
AT (1) | ATE233734T1 (fr) |
AU (1) | AU703493B2 (fr) |
BG (1) | BG62442B1 (fr) |
CO (1) | CO4440626A1 (fr) |
DE (1) | DE69529849T2 (fr) |
DK (1) | DK0832069T3 (fr) |
DZ (1) | DZ2045A1 (fr) |
IL (3) | IL135377A (fr) |
MA (1) | MA23895A1 (fr) |
MX (1) | MX9709914A (fr) |
OA (1) | OA10363A (fr) |
RO (1) | RO116897B1 (fr) |
RU (1) | RU2141478C1 (fr) |
TN (1) | TNSN96085A1 (fr) |
TR (1) | TR199600481A2 (fr) |
TW (1) | TW476756B (fr) |
YU (1) | YU35296A (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9709137A (pt) * | 1996-04-30 | 1999-08-03 | Pfizer | Processos e intermediários para a preparação de [2-(2H-[1,2,4]triazol-3-ilmetil)-1,2,3,4-tetra-hidro-isoquinolin-6-il]-amida do ácido 4'-trifluorometilbifenil-2-carboxílico |
JP2959765B2 (ja) | 1997-12-12 | 1999-10-06 | 日本たばこ産業株式会社 | 3−ピペリジル−4−オキソキナゾリン誘導体及びそれを含有してなる医薬組成物 |
CA2325358C (fr) * | 1999-11-10 | 2005-08-02 | Pfizer Products Inc. | Amides de l'acide 7-¬(4'-trifluoromethylbiphenyl-2-carbonyl)amino|-quinoleine-3-carboxylique et methodes pour inhiber la secretion d'apolipoproteine b |
WO2001053260A1 (fr) * | 2000-01-18 | 2001-07-26 | Novartis Ag | Carboxamides utilises comme inhibiteurs de proteine de transfert triglyceridique microsomique et de la secretion d'apolipoproteine b |
JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
JO2409B1 (en) * | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
US6953671B2 (en) * | 2001-02-23 | 2005-10-11 | The Trustees Of Columbia University In The City Of New York | Plasma phospholipid transfer protein (PLTP) deficiency represents an anti-atherogenic state and PLTP inhibitor has anti-atherosclerosis action |
SI1404653T1 (sl) * | 2001-06-28 | 2008-12-31 | Pfizer Prod Inc | S triamidom substituirani indoli, benzofurani in benzotiofeni kot zaviralci mikrosomske prenašalnebeljakovine za trigliceride (MTP) in/ali izločanja apolipoproteina B (APO B) |
EP1483233A4 (fr) * | 2002-03-13 | 2005-12-21 | Univ Tennessee Res Corp | Composes tetrahydroisoquinoleine substitues, procedes de preparation et utilisation de ceux-ci |
CA2546601A1 (fr) | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Nouvelles substances thyromimetiques contenant du phosphore |
WO2005051945A1 (fr) * | 2003-11-20 | 2005-06-09 | Eli Lilly And Company | Composes heterocycliques utilises comme modulateurs des recepteurs actives proliferateurs du peroxysome (ppar), utiles dans le traitement et/ou la prevention de troubles modules par un ppar |
CA2555133A1 (fr) * | 2004-02-04 | 2005-09-01 | Pfizer Products Inc. | Composes de quinoline substitues |
US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
JP2006249022A (ja) | 2005-03-11 | 2006-09-21 | Sumitomo Chemical Co Ltd | 4−(2−メチルフェニル)ベンゾトリフルオライドの製造方法 |
SG164371A1 (en) * | 2005-04-19 | 2010-09-29 | Surface Logix Inc | Inhibitors of microsomal triglyceride transfer protein and apo-b secretion |
WO2006129193A2 (fr) * | 2005-05-27 | 2006-12-07 | Pfizer Products Inc. | Polytherapie pour le traitement de l'obesite ou le maintien du poids apres une perte ponderale |
CN102851291B (zh) * | 2006-04-03 | 2016-03-09 | 斯特拉有限责任公司 | 包含抗微小rna反义寡核苷酸的药物组合物 |
DK2666859T3 (en) | 2006-04-03 | 2019-04-08 | Roche Innovation Ct Copenhagen As | PHARMACEUTICAL COMPOSITION CONTAINING ANTI-miRNA ANTISENSE OLIGONUCLEOTIDES |
GB0619176D0 (en) * | 2006-09-29 | 2006-11-08 | Lectus Therapeutics Ltd | Ion channel modulators & uses thereof |
CA2666191C (fr) * | 2006-10-09 | 2017-07-11 | Santaris Pharma A/S | Composes antagonistes de l'arn pour la modulation de pcsk9 |
US20100210633A1 (en) * | 2006-10-12 | 2010-08-19 | Epix Delaware, Inc. | Carboxamide compounds and their use |
US8580756B2 (en) * | 2007-03-22 | 2013-11-12 | Santaris Pharma A/S | Short oligomer antagonist compounds for the modulation of target mRNA |
CA2681406A1 (fr) * | 2007-03-22 | 2008-09-25 | Santaris Pharma A/S | Composes arn antagonistes pour l'inhibition de l'expression de l'apo-b100 |
US20110054011A1 (en) * | 2007-08-30 | 2011-03-03 | Mccullagh Keith | RNA Antagonist Compounds for the Modulation of FABP4/AP2 |
ES2463665T3 (es) * | 2007-10-04 | 2014-05-28 | Stella Aps | Tratamiento de combinación para el tratamiento de infección por virus de la hepatitis C |
US8569282B2 (en) | 2007-12-11 | 2013-10-29 | Cytopathfinder, Inc. | Carboxamide compounds and their use |
CA2717792A1 (fr) * | 2008-03-07 | 2009-09-11 | Santaris Pharma A/S | Compositions pharmaceutiques pour le traitement de maladies associees aux microarn |
WO2010012667A1 (fr) | 2008-08-01 | 2010-02-04 | Santaris Pharma A/S | Modulation à médiation par micro-arn de facteurs stimulateurs de colonies |
CA2741153A1 (fr) * | 2008-10-29 | 2010-05-06 | F. Hoffmann-La Roche Ag | Nouveaux derives d'amides phenyliques ou d'amides pyridyliques et leur utilisation en tant agonistes de gpbar1 |
WO2010093601A1 (fr) | 2009-02-10 | 2010-08-19 | Metabasis Therapeutics, Inc. | Nouveaux thyromimetiques contenant de l'acide sulfonique et methodes d'utilisation associees |
JP5773535B2 (ja) * | 2009-04-24 | 2015-09-02 | ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S | インターフェロンに非応答性のhcv患者の治療のための医薬組成物 |
WO2010127208A1 (fr) * | 2009-04-30 | 2010-11-04 | Forest Laboratories Holdings Limited | Inhibiteurs de l'acétyl-coa carboxylase |
US20100280067A1 (en) * | 2009-04-30 | 2010-11-04 | Pakala Kumara Savithru Sarma | Inhibitors of acetyl-coa carboxylase |
EP2456870A1 (fr) | 2009-07-21 | 2012-05-30 | Santaris Pharma A/S | Oligomères anti-sens ciblant pcsk9 |
CA2817093A1 (fr) * | 2010-11-15 | 2012-05-24 | Abbvie Inc. | Inhibiteurs de nampt |
EP3591054A1 (fr) | 2013-06-27 | 2020-01-08 | Roche Innovation Center Copenhagen A/S | Oligomères et conjugués antisens ciblant pcsk9 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4022900A (en) * | 1970-09-09 | 1977-05-10 | Marion Laboratories, Inc. | Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents |
CA1248536A (fr) * | 1982-09-10 | 1989-01-10 | Wellcome Foundation Limited (The) | Derives d'acide benzoique |
GB9127306D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicycle compounds and pharmaceuticals containing them |
US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
EP0944602A1 (fr) * | 1996-11-27 | 1999-09-29 | Pfizer Inc. | Amides inhibant la secretion d'apo b et/ou la proteine mtp |
-
1995
- 1995-06-07 US US08/952,507 patent/US5919795A/en not_active Expired - Fee Related
- 1995-06-07 DK DK95918722T patent/DK0832069T3/da active
- 1995-06-07 AT AT95918722T patent/ATE233734T1/de not_active IP Right Cessation
- 1995-06-07 DE DE69529849T patent/DE69529849T2/de not_active Expired - Fee Related
- 1995-06-07 MX MX9709914A patent/MX9709914A/es not_active IP Right Cessation
-
1996
- 1996-04-19 TW TW085104696A patent/TW476756B/zh not_active IP Right Cessation
- 1996-05-30 IL IL13537796A patent/IL135377A/en not_active IP Right Cessation
- 1996-05-30 IL IL13537596A patent/IL135375A/en not_active IP Right Cessation
- 1996-05-30 IL IL13537696A patent/IL135376A/en not_active IP Right Cessation
- 1996-06-03 AR ARP960102871A patent/AR003424A1/es unknown
- 1996-06-05 KR KR1019960020168A patent/KR100225713B1/ko not_active IP Right Cessation
- 1996-06-05 BG BG100637A patent/BG62442B1/bg unknown
- 1996-06-05 DZ DZ960089A patent/DZ2045A1/fr active
- 1996-06-06 TN TNTNSN96085A patent/TNSN96085A1/fr unknown
- 1996-06-06 TR TR96/00481A patent/TR199600481A2/xx unknown
- 1996-06-06 AU AU54784/96A patent/AU703493B2/en not_active Ceased
- 1996-06-06 RU RU96111018A patent/RU2141478C1/ru not_active IP Right Cessation
- 1996-06-06 MA MA24265A patent/MA23895A1/fr unknown
- 1996-06-06 YU YU35296A patent/YU35296A/sh unknown
- 1996-06-07 OA OA60837A patent/OA10363A/en unknown
- 1996-06-07 CO CO96029732A patent/CO4440626A1/es unknown
- 1996-06-07 RO RO96-01181A patent/RO116897B1/ro unknown
Also Published As
Publication number | Publication date |
---|---|
MA23895A1 (fr) | 1996-12-31 |
TR199600481A2 (tr) | 1996-12-21 |
DE69529849T2 (de) | 2003-09-04 |
BG100637A (bg) | 1997-03-31 |
RO116897B1 (ro) | 2001-07-30 |
DK0832069T3 (da) | 2003-04-22 |
YU35296A (sh) | 1999-06-15 |
IL135375A (en) | 2001-07-24 |
AU703493B2 (en) | 1999-03-25 |
TNSN96085A1 (fr) | 2005-03-15 |
TW476756B (en) | 2002-02-21 |
RU2141478C1 (ru) | 1999-11-20 |
IL135377A0 (en) | 2001-05-20 |
KR970003589A (ko) | 1997-01-28 |
DE69529849D1 (de) | 2003-04-10 |
AU5478496A (en) | 1996-12-19 |
IL135376A0 (en) | 2001-05-20 |
MX9709914A (es) | 1998-03-31 |
IL135377A (en) | 2001-05-20 |
IL135376A (en) | 2001-05-20 |
KR100225713B1 (ko) | 1999-10-15 |
US5919795A (en) | 1999-07-06 |
CO4440626A1 (es) | 1997-05-07 |
BG62442B1 (bg) | 1999-11-30 |
OA10363A (en) | 2001-11-15 |
IL135375A0 (en) | 2001-05-20 |
AR003424A1 (es) | 1998-08-05 |
ATE233734T1 (de) | 2003-03-15 |
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