BR9506244A - 5-(Citosinil-1)1,3-oxatiolanos de configuração cis (2r-5r)compostos nicotínicos compostos dihidropirídicos compostos nicotínicos quaternizados compostos quinolênicos compostos dihidroquinoleinila compostos quinoleinilas quaternizados compsotos (dihidropiridil alquila)sais de adição com ácido orgânico ou mineral isômeros oticamente ativos dos compostos processo para a produção de compostos e composições farmacêuticas com ação antiviral - Google Patents
5-(Citosinil-1)1,3-oxatiolanos de configuração cis (2r-5r)compostos nicotínicos compostos dihidropirídicos compostos nicotínicos quaternizados compostos quinolênicos compostos dihidroquinoleinila compostos quinoleinilas quaternizados compsotos (dihidropiridil alquila)sais de adição com ácido orgânico ou mineral isômeros oticamente ativos dos compostos processo para a produção de compostos e composições farmacêuticas com ação antiviralInfo
- Publication number
- BR9506244A BR9506244A BR9506244A BR9506244A BR9506244A BR 9506244 A BR9506244 A BR 9506244A BR 9506244 A BR9506244 A BR 9506244A BR 9506244 A BR9506244 A BR 9506244A BR 9506244 A BR9506244 A BR 9506244A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- quaternized
- nicotinic
- dihydropyridic
- dihydroquinoleinyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 8
- 229910052500 inorganic mineral Inorganic materials 0.000 title 2
- 239000011707 mineral Substances 0.000 title 2
- WJJSZTJGFCFNKI-UHFFFAOYSA-N 1,3-oxathiolane Chemical class C1CSCO1 WJJSZTJGFCFNKI-UHFFFAOYSA-N 0.000 title 1
- 230000000840 anti-viral effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9406262A FR2720397B1 (fr) | 1994-05-24 | 1994-05-24 | Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment. |
| PCT/FR1995/000683 WO1995032200A1 (fr) | 1994-05-24 | 1995-05-24 | Oxathiolanes, leur procede de preparation et les compositions pharmaceutiques qui en renferment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9506244A true BR9506244A (pt) | 1997-08-12 |
Family
ID=9463449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9506244A BR9506244A (pt) | 1994-05-24 | 1995-05-24 | 5-(Citosinil-1)1,3-oxatiolanos de configuração cis (2r-5r)compostos nicotínicos compostos dihidropirídicos compostos nicotínicos quaternizados compostos quinolênicos compostos dihidroquinoleinila compostos quinoleinilas quaternizados compsotos (dihidropiridil alquila)sais de adição com ácido orgânico ou mineral isômeros oticamente ativos dos compostos processo para a produção de compostos e composições farmacêuticas com ação antiviral |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5708000A (pt) |
| EP (1) | EP0733053A1 (pt) |
| JP (1) | JPH09502453A (pt) |
| KR (1) | KR100242891B1 (pt) |
| CN (1) | CN1080264C (pt) |
| AP (1) | AP612A (pt) |
| AU (1) | AU688052B2 (pt) |
| BR (1) | BR9506244A (pt) |
| CA (1) | CA2167930A1 (pt) |
| CZ (1) | CZ21996A3 (pt) |
| FI (1) | FI960316A (pt) |
| FR (1) | FR2720397B1 (pt) |
| HU (1) | HU219299B (pt) |
| NO (1) | NO306299B1 (pt) |
| NZ (1) | NZ287478A (pt) |
| OA (1) | OA10258A (pt) |
| PL (1) | PL181713B1 (pt) |
| RU (1) | RU2142462C1 (pt) |
| WO (1) | WO1995032200A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2720397B1 (fr) * | 1994-05-24 | 1996-08-23 | Laphal Laboratoires Sa | Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment. |
| IT1290447B1 (it) * | 1997-03-28 | 1998-12-03 | Zambon Spa | Derivati 1,3-ossatiolanici ad attivita' antivirale |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| BR122018075478B8 (pt) * | 2004-06-24 | 2023-10-31 | Vertex Pharma | moduladores de transportadores de cassete de ligação de atp |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| US20090105272A1 (en) * | 2005-12-24 | 2009-04-23 | Grootenhuis Peter D J | Prodrugs of modulators of ABC transporters |
| HUE049976T2 (hu) | 2005-12-28 | 2020-11-30 | Vertex Pharma | N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói |
| PE20071025A1 (es) * | 2006-01-31 | 2007-10-17 | Mitsubishi Tanabe Pharma Corp | Compuesto amina trisustituido |
| SG10201504084QA (en) | 2009-03-20 | 2015-06-29 | Vertex Pharma | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| CN109966264A (zh) | 2012-02-27 | 2019-07-05 | 沃泰克斯药物股份有限公司 | 药物组合物及其施用 |
| CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
| DK0560794T3 (da) * | 1990-11-13 | 1996-12-23 | Iaf Biochem Int | Substituerede 1,3-oxathiolaner med antivirale egenskaber |
| DK0513917T4 (da) * | 1991-05-16 | 2001-06-25 | Glaxo Group Ltd | Antivirale kombinationer indeholdende nukleosidanaloger |
| GB9110874D0 (en) * | 1991-05-20 | 1991-07-10 | Iaf Biochem Int | Medicaments |
| FR2720397B1 (fr) * | 1994-05-24 | 1996-08-23 | Laphal Laboratoires Sa | Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment. |
-
1994
- 1994-05-24 FR FR9406262A patent/FR2720397B1/fr not_active Expired - Fee Related
-
1995
- 1995-05-24 JP JP7530108A patent/JPH09502453A/ja not_active Ceased
- 1995-05-24 CZ CZ96219A patent/CZ21996A3/cs unknown
- 1995-05-24 KR KR1019960700446A patent/KR100242891B1/ko not_active IP Right Cessation
- 1995-05-24 RU RU96105063A patent/RU2142462C1/ru active
- 1995-05-24 AU AU26209/95A patent/AU688052B2/en not_active Ceased
- 1995-05-24 PL PL95312693A patent/PL181713B1/pl unknown
- 1995-05-24 BR BR9506244A patent/BR9506244A/pt active Search and Examination
- 1995-05-24 CN CN95190647A patent/CN1080264C/zh not_active Expired - Fee Related
- 1995-05-24 EP EP95920986A patent/EP0733053A1/fr not_active Withdrawn
- 1995-05-24 WO PCT/FR1995/000683 patent/WO1995032200A1/fr not_active Application Discontinuation
- 1995-05-24 HU HU9600155A patent/HU219299B/hu not_active IP Right Cessation
- 1995-05-24 US US08/586,892 patent/US5708000A/en not_active Expired - Fee Related
- 1995-05-24 CA CA002167930A patent/CA2167930A1/fr not_active Abandoned
- 1995-05-25 NZ NZ287478A patent/NZ287478A/en unknown
-
1996
- 1996-01-23 FI FI960316A patent/FI960316A/fi unknown
- 1996-01-23 NO NO960272A patent/NO306299B1/no not_active IP Right Cessation
- 1996-01-23 AP APAP/P/1996/000784A patent/AP612A/en active
- 1996-01-24 OA OA60770A patent/OA10258A/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI960316A0 (fi) | 1996-01-23 |
| NO306299B1 (no) | 1999-10-18 |
| HU219299B (en) | 2001-03-28 |
| FR2720397B1 (fr) | 1996-08-23 |
| EP0733053A1 (fr) | 1996-09-25 |
| FR2720397A1 (fr) | 1995-12-01 |
| PL312693A1 (en) | 1996-05-13 |
| PL181713B1 (en) | 2001-09-28 |
| HUT75112A (en) | 1997-04-28 |
| NO960272L (no) | 1996-01-23 |
| CA2167930A1 (fr) | 1995-11-30 |
| AU688052B2 (en) | 1998-03-05 |
| NO960272D0 (no) | 1996-01-23 |
| JPH09502453A (ja) | 1997-03-11 |
| CN1130906A (zh) | 1996-09-11 |
| CN1080264C (zh) | 2002-03-06 |
| AU2620995A (en) | 1995-12-18 |
| NZ287478A (en) | 1997-09-22 |
| FI960316A (fi) | 1996-03-22 |
| OA10258A (fr) | 1997-10-07 |
| US5708000A (en) | 1998-01-13 |
| KR100242891B1 (ko) | 2000-03-02 |
| RU2142462C1 (ru) | 1999-12-10 |
| AP612A (en) | 1997-09-05 |
| CZ21996A3 (en) | 1996-05-15 |
| WO1995032200A1 (fr) | 1995-11-30 |
| KR960703903A (ko) | 1996-08-31 |
| AP9600784A0 (en) | 1996-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB36 | Technical and formal requirements: requirement - article 36 of industrial property law | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |