PT100689A - Derivados de 2-(4-hidroxipiperidino)-1-alcanol como agentes anti-isquemicos - Google Patents

Derivados de 2-(4-hidroxipiperidino)-1-alcanol como agentes anti-isquemicos

Info

Publication number
PT100689A
PT100689A PT100689A PT10068992A PT100689A PT 100689 A PT100689 A PT 100689A PT 100689 A PT100689 A PT 100689A PT 10068992 A PT10068992 A PT 10068992A PT 100689 A PT100689 A PT 100689A
Authority
PT
Portugal
Prior art keywords
hydroxipipididine
alcanol
derivatives
ischemic agents
ischemic
Prior art date
Application number
PT100689A
Other languages
English (en)
Other versions
PT100689B (pt
Inventor
Willard Mckowan Welch Jr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT100689A publication Critical patent/PT100689A/pt
Publication of PT100689B publication Critical patent/PT100689B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT100689A 1991-07-17 1992-07-15 Derivados de 2-(4-hidroxipiperidino)-1-alcanol como agentes anti-isquemicos PT100689B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73157791A 1991-07-17 1991-07-17

Publications (2)

Publication Number Publication Date
PT100689A true PT100689A (pt) 1993-10-29
PT100689B PT100689B (pt) 1999-06-30

Family

ID=24940103

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100689A PT100689B (pt) 1991-07-17 1992-07-15 Derivados de 2-(4-hidroxipiperidino)-1-alcanol como agentes anti-isquemicos

Country Status (22)

Country Link
EP (1) EP0594729A1 (pt)
JP (1) JP2571904B2 (pt)
KR (1) KR0165003B1 (pt)
CN (1) CN1043759C (pt)
AU (1) AU655840B2 (pt)
BR (1) BR9206272A (pt)
CA (1) CA2113568A1 (pt)
CZ (1) CZ284133B6 (pt)
EG (1) EG20048A (pt)
FI (2) FI940192A (pt)
HU (1) HUT70528A (pt)
IE (1) IE922311A1 (pt)
IL (1) IL102473A (pt)
MX (1) MX9204190A (pt)
NO (1) NO180445C (pt)
NZ (1) NZ243580A (pt)
PL (1) PL169884B1 (pt)
PT (1) PT100689B (pt)
RU (1) RU2065859C1 (pt)
TW (1) TW201732B (pt)
WO (1) WO1993002052A1 (pt)
ZA (1) ZA925306B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
BR9307331A (pt) * 1992-10-30 1999-05-25 Pfizer Compostos neuroprotetores 3,4-dihidro-2(1ho-quinolona
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
WO2000061558A1 (fr) * 1999-04-09 2000-10-19 Mochida Pharmaceutical Co., Ltd. Remedes pour douleurs neurogenes
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
CA2386441A1 (en) 1999-10-29 2001-05-03 Merck Sharp & Dohme Limited Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
SI1379520T1 (sl) 2001-02-23 2006-08-31 Merck & Co Inc N-substituirani nonaril-heterociklicni NMDA/NR2B antagonisti
WO2002080928A1 (en) 2001-04-03 2002-10-17 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
CA2507509A1 (en) 2002-11-25 2004-06-10 Mochida Pharmaceutical Co., Ltd. Therapeutic agent for respiratory disease containing 4-hydroxypiperidine derivative as active ingredient
JP2007508288A (ja) * 2003-10-08 2007-04-05 ファイザー株式会社 縮合ラクタム化合物
TWI409289B (zh) 2010-09-02 2013-09-21 Taiwan Union Technology Corp 由氮氧雜環化合物所製得之聚合物之穩態溶液及其製法與用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FR2546166B1 (fr) * 1983-05-19 1985-10-25 Synthelabo Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
EP0398578B1 (en) * 1989-05-17 1997-03-12 Pfizer Inc. 2-piperidino-1-alkanol derivatives as antiischemic agents
CA2080475C (en) * 1990-05-10 2001-04-17 Bertrand Leo Chenard Neuroprotective indolone and related derivatives

Also Published As

Publication number Publication date
ZA925306B (en) 1994-01-17
KR0165003B1 (en) 1999-01-15
IL102473A0 (en) 1993-01-14
NO940144D0 (no) 1994-01-14
CN1043759C (zh) 1999-06-23
JPH06504293A (ja) 1994-05-19
TW201732B (pt) 1993-03-11
NO940144L (no) 1994-01-14
IL102473A (en) 1997-07-13
FI940192A0 (fi) 1994-01-14
AU655840B2 (en) 1995-01-12
EG20048A (en) 1997-03-27
BR9206272A (pt) 1995-04-11
CN1068566A (zh) 1993-02-03
FI940192A (fi) 1994-01-14
IE922311A1 (en) 1993-01-27
EP0594729A1 (en) 1994-05-04
NZ243580A (en) 1994-10-26
PL169884B1 (pl) 1996-09-30
MX9204190A (es) 1993-01-01
RU2065859C1 (ru) 1996-08-27
FI981956A (fi) 1998-09-11
AU2322592A (en) 1993-02-23
PT100689B (pt) 1999-06-30
CZ400892A3 (en) 1994-03-16
NO180445C (no) 1997-04-23
CA2113568A1 (en) 1993-02-04
CZ284133B6 (cs) 1998-08-12
WO1993002052A1 (en) 1993-02-04
NO180445B (no) 1997-01-13
HU9400136D0 (en) 1994-05-30
JP2571904B2 (ja) 1997-01-16
HUT70528A (en) 1995-10-30
FI981956A0 (fi) 1998-09-11

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19930421

FG3A Patent granted, date of granting

Effective date: 19990316

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20010930