DK154192D0 - Heterocycliske forbindelser - Google Patents

Heterocycliske forbindelser

Info

Publication number
DK154192D0
DK154192D0 DK921541A DK154192A DK154192D0 DK 154192 D0 DK154192 D0 DK 154192D0 DK 921541 A DK921541 A DK 921541A DK 154192 A DK154192 A DK 154192A DK 154192 D0 DK154192 D0 DK 154192D0
Authority
DK
Denmark
Prior art keywords
heterocyclic compounds
heterocyclic
compounds
Prior art date
Application number
DK921541A
Other languages
English (en)
Inventor
Peter Moldt
Joergen Scheel-Krueger
Leif Helth Jensen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of DK154192D0 publication Critical patent/DK154192D0/da
Priority to DK921541A priority Critical patent/DK154192D0/da
Application filed by Neurosearch As filed Critical Neurosearch As
Priority to US08/093,183 priority patent/US5369113A/en
Priority to US08/093,181 priority patent/US5444070A/en
Priority to US08/093,182 priority patent/US5374636A/en
Priority to US08/093,184 priority patent/US5554626A/en
Priority to AU52362/93A priority patent/AU672052B2/en
Priority to AU52363/93A priority patent/AU672644B2/en
Priority to AU52361/93A priority patent/AU671163B2/en
Priority to ZA939367A priority patent/ZA939367B/xx
Priority to ZA939365A priority patent/ZA939365B/xx
Priority to ZA939366A priority patent/ZA939366B/xx
Priority to DE69332636T priority patent/DE69332636T2/de
Priority to DE69332366T priority patent/DE69332366T2/de
Priority to AT93610066T priority patent/ATE195314T1/de
Priority to NZ250513A priority patent/NZ250513A/en
Priority to ES93610066T priority patent/ES2149193T3/es
Priority to AT93610065T priority patent/ATE231147T1/de
Priority to AT93610063T priority patent/ATE225787T1/de
Priority to DK93610066T priority patent/DK0604355T3/da
Priority to EP93610066A priority patent/EP0604355B1/en
Priority to PT93610066T priority patent/PT604355E/pt
Priority to NZ250514A priority patent/NZ250514A/en
Priority to NZ250515A priority patent/NZ250515A/en
Priority to EP93610065A priority patent/EP0604354B1/en
Priority to DE69329184T priority patent/DE69329184T2/de
Priority to EP93610063A priority patent/EP0604352B1/en
Priority to CA002112061A priority patent/CA2112061C/en
Priority to CA002112083A priority patent/CA2112083C/en
Priority to CA002112084A priority patent/CA2112084C/en
Priority to NO934760A priority patent/NO301227B1/no
Priority to FI935800A priority patent/FI935800A/fi
Priority to JP5324475A priority patent/JPH06293760A/ja
Priority to NO934758A priority patent/NO301164B1/no
Priority to FI935798A priority patent/FI935798A/fi
Priority to JP32447193A priority patent/JP3841449B2/ja
Priority to FI935799A priority patent/FI935799A/fi
Priority to NO934761A priority patent/NO303578B1/no
Priority to JP5324472A priority patent/JPH06293759A/ja
Priority to KR1019930029245A priority patent/KR100310663B1/ko
Priority to KR1019930029243A priority patent/KR100300799B1/ko
Priority to KR1019930029244A priority patent/KR100344328B1/ko
Priority to GR20000402434T priority patent/GR3034746T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
DK921541A 1992-12-23 1992-12-23 Heterocycliske forbindelser DK154192D0 (da)

Priority Applications (42)

Application Number Priority Date Filing Date Title
DK921541A DK154192D0 (da) 1992-12-23 1992-12-23 Heterocycliske forbindelser
US08/093,183 US5369113A (en) 1992-12-23 1993-07-16 Certain 2,3-diphenyl-2-(1,2,4-oxadiazol-5-yl)tropanes useful as dopamide reuptake inhibitors
US08/093,181 US5444070A (en) 1992-12-23 1993-07-16 Phenyl substituted heterocyclic compounds
US08/093,182 US5374636A (en) 1992-12-23 1993-07-16 2,3-trans-disubstituted tropane compounds which have useful pharmaceutical utility
US08/093,184 US5554626A (en) 1992-12-23 1993-07-16 Substituted heterocyclic compounds as dopamine-reuptake inhibitors
AU52362/93A AU672052B2 (en) 1992-12-23 1993-12-13 Antidepressant and antiparkinsonian compounds
AU52361/93A AU671163B2 (en) 1992-12-23 1993-12-13 Alkyl substituted heterocyclic compounds
AU52363/93A AU672644B2 (en) 1992-12-23 1993-12-13 Aryl substituted heterocyclic compounds
ZA939367A ZA939367B (en) 1992-12-23 1993-12-14 Antidepressant and antiperkinsonian compounds
ZA939365A ZA939365B (en) 1992-12-23 1993-12-14 Alkyl substituted heterocyclic compounds
ZA939366A ZA939366B (en) 1992-12-23 1993-12-14 Aryl substituted heterocyclic compounds
EP93610063A EP0604352B1 (en) 1992-12-23 1993-12-20 Aryl-substituted heterocyclic compounds
PT93610066T PT604355E (pt) 1992-12-23 1993-12-20 Compostos heterociclicos substituidos por alquilo
DE69332366T DE69332366T2 (de) 1992-12-23 1993-12-20 Arylsubstituierte heterocyclische Verbindungen
AT93610066T ATE195314T1 (de) 1992-12-23 1993-12-20 Alkylsubstituierte heterocyclische verbindungen
NZ250513A NZ250513A (en) 1992-12-23 1993-12-20 Substituted 8-aza-bicyclo[3.2.1]octanes; medicaments
ES93610066T ES2149193T3 (es) 1992-12-23 1993-12-20 Compuestos heterociclicos sustituidos con alquilo.
AT93610065T ATE231147T1 (de) 1992-12-23 1993-12-20 Antidepressiv und gegen die parkinsonsche krankheit wirkende verbindungen
AT93610063T ATE225787T1 (de) 1992-12-23 1993-12-20 Arylsubstituierte heterocyclische verbindungen
DK93610066T DK0604355T3 (da) 1992-12-23 1993-12-20 Arylsubstituerede heterocykliske forbindelser
EP93610066A EP0604355B1 (en) 1992-12-23 1993-12-20 Akyl Substituted heterocyclic compounds
DE69332636T DE69332636T2 (de) 1992-12-23 1993-12-20 Antidepressiv und gegen die Parkinsonsche Krankheit wirkende Verbindungen
NZ250514A NZ250514A (en) 1992-12-23 1993-12-20 Substituted 8-aza-bicyclo[3.2.1]octanes; medicaments
NZ250515A NZ250515A (en) 1992-12-23 1993-12-20 Substituted 8-aza-bicyclo[3.2.1]octanes and medicaments
EP93610065A EP0604354B1 (en) 1992-12-23 1993-12-20 Antidepressant and antiparkinsonian compounds
DE69329184T DE69329184T2 (de) 1992-12-23 1993-12-20 Alkylsubstituierte heterocyclische Verbindungen
CA002112084A CA2112084C (en) 1992-12-23 1993-12-21 Antidepressant and antiparkinsonian compounds
CA002112061A CA2112061C (en) 1992-12-23 1993-12-21 Alkyl substituted heterocyclic compounds
CA002112083A CA2112083C (en) 1992-12-23 1993-12-21 Aryl substituted heterocyclic compounds
JP5324472A JPH06293759A (ja) 1992-12-23 1993-12-22 アルキル置換複素環式化合物
FI935798A FI935798A (fi) 1992-12-23 1993-12-22 Alkyylisubstituoituja heterosyklisiä yhdisteitä
FI935800A FI935800A (fi) 1992-12-23 1993-12-22 Masennuksenvastaisia ja Parkinsonin taudin vastaisia yhdisteitä
JP5324475A JPH06293760A (ja) 1992-12-23 1993-12-22 アリール置換ヘテロ環式化合物
NO934758A NO301164B1 (no) 1992-12-23 1993-12-22 Alkylsubstituerte, heterosykliske forbindelser, anvendelser derav og farmasöytisk preparat som omfatter en slik forbindelse
NO934760A NO301227B1 (no) 1992-12-23 1993-12-22 Arylsubstituerte, heterosykliske forbindelser, anvendelser derav og farmasöytisk preparat som omfatter en slik forbindelse
JP32447193A JP3841449B2 (ja) 1992-12-23 1993-12-22 抗鬱病および抗パーキンソン氏病化合物
FI935799A FI935799A (fi) 1992-12-23 1993-12-22 Aryylisubstituoituja heterosyklisiä yhdisteitä
NO934761A NO303578B1 (no) 1992-12-23 1993-12-22 Anvendelse av 2,3-trans-disubstituerte tropanforbindelser for fremstilling av medikamenter, samt slike forbindelser og farmas°ytiske preparater som omfatter dem
KR1019930029245A KR100310663B1 (ko) 1992-12-23 1993-12-23 트로판유도체,이의제조방법및이를함유하는약제학적조성물
KR1019930029243A KR100300799B1 (ko) 1992-12-23 1993-12-23 알킬치환된헤테로사이클릭화합물,이를포함하는약제학적조성물및이의제조방법
KR1019930029244A KR100344328B1 (ko) 1992-12-23 1993-12-23 아릴치환된헤테로사이클릭화합물,이의제조방법및이를함유하는약제학적조성물
GR20000402434T GR3034746T3 (en) 1992-12-23 2000-11-02 Akyl Substituted heterocyclic compounds.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK921541A DK154192D0 (da) 1992-12-23 1992-12-23 Heterocycliske forbindelser

Publications (1)

Publication Number Publication Date
DK154192D0 true DK154192D0 (da) 1992-12-23

Family

ID=8105889

Family Applications (1)

Application Number Title Priority Date Filing Date
DK921541A DK154192D0 (da) 1992-12-23 1992-12-23 Heterocycliske forbindelser

Country Status (4)

Country Link
US (3) US5444070A (da)
KR (3) KR100344328B1 (da)
DK (1) DK154192D0 (da)
ZA (3) ZA939366B (da)

Families Citing this family (45)

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US7011813B2 (en) * 1990-08-09 2006-03-14 Research Triangle Institute Cocaine receptor binding ligands
US6706880B2 (en) * 1990-08-09 2004-03-16 Research Triangle Institute Cocaine receptor binding ligands
US6329520B1 (en) * 1990-08-09 2001-12-11 Research Triangle Institute Cocaine receptor binding ligands
US6531483B1 (en) * 1990-08-09 2003-03-11 Research Triangle Institute Cocaine receptor binding ligands
US7189737B2 (en) * 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US5935953A (en) * 1990-08-09 1999-08-10 Research Triangle Institute Methods for controlling invertebrate pests using cocaine receptor binding ligands
US5736123A (en) * 1990-08-09 1998-04-07 Research Triangle Institute Cocaine receptor binding ligands
US5750089A (en) * 1996-01-11 1998-05-12 Neuro Imaging Technologies, Llc Halogenated neuroprobe for mapping monoamine reuptake sites
US5698179A (en) * 1992-02-25 1997-12-16 Neuro Imaging Technologies, Llc Iodinated neuroprobe for mapping monoamine reuptake sites
US5760055A (en) * 1992-03-13 1998-06-02 Wake Forest University Biologically active tropane derivatives
US6632456B1 (en) * 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
EP0831941B1 (en) * 1995-06-06 2012-04-04 GE Healthcare Limited Iodinated neuroprobes for mapping monoamine reuptake sites
PL185357B1 (pl) * 1995-10-13 2003-04-30 Neurosearch As Pochodne 8-azabicyklo [3.2.1] okt-2-enowe, ich wytwarzanie i zastosowanie
US5948933A (en) * 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
AU778629B2 (en) * 1996-08-22 2004-12-16 Research Triangle Institute Cocaine receptor binding ligands
JP2001505576A (ja) * 1996-12-02 2001-04-24 ジョージタウン ユニバーシティ トロパン誘導体類及びそれらの合成方法
US5834484A (en) * 1997-03-12 1998-11-10 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Cocaine analogs
US6013242A (en) * 1998-01-13 2000-01-11 Wake Forest University Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
DK1246806T3 (da) * 1999-11-03 2008-06-16 Amr Technology Inc Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin
EP1257541B1 (en) * 2000-01-11 2008-09-03 Molecular Insight Pharmaceuticals, Inc. Polypharmacophoric agents
US6479509B1 (en) 2000-05-22 2002-11-12 Research Triangle Institute Method of promoting smoking cessation
KR100821410B1 (ko) * 2000-07-11 2008-04-10 에이엠알 테크놀로지, 인크. 4-페닐 치환된 테트라하이드로이소퀴놀린 및 이의치료학적 용도
US20040030131A1 (en) * 2000-10-04 2004-02-12 Martine Keenan Pharmaceutical compounds
JP2004520396A (ja) * 2001-02-15 2004-07-08 ニューロサーチ、アクティーゼルスカブ 過剰な又は不十分な細胞死によって特徴づけられる疾患の治療
EP1397358A1 (en) * 2001-05-23 2004-03-17 Neurosearch A/S Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20040235906A1 (en) * 2001-08-08 2004-11-25 Gouliaev Alex Haahr Substituted amine derivatives and their use as monoamine neurotransmitter re-up-take inhibitors
ATE345135T1 (de) * 2001-11-30 2006-12-15 Neurosearch As Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen
JP2005529156A (ja) * 2002-03-28 2005-09-29 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ トロパン化合物
WO2005039580A1 (en) 2003-10-16 2005-05-06 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor
AU2005205882A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist
AU2005205880B2 (en) * 2004-01-22 2010-06-10 Neurosearch A/S Compounds for the sustained reduction of body weight
US20050278472A1 (en) * 2004-06-14 2005-12-15 Gierke Justin T USB extender
KR101389246B1 (ko) 2004-07-15 2014-04-24 브리스톨-마이어스스퀴브컴파니 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
US20060111385A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
US20060111394A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US20060111393A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
JP5258561B2 (ja) * 2005-07-15 2013-08-07 アルバニー モレキュラー リサーチ， インコーポレイテッド アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
EP1779851A1 (en) * 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Treatment of diabetes
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) * 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
JP5739415B2 (ja) * 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
EP2429296B1 (en) 2009-05-12 2017-12-27 Albany Molecular Research, Inc. 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
MX2011011901A (es) 2009-05-12 2012-01-20 Albany Molecular Res Inc Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
US9045468B2 (en) 2010-08-17 2015-06-02 Albany Molecular Research, Inc. 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

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Also Published As

Publication number Publication date
KR940013555A (ko) 1994-07-15
KR100300799B1 (ko) 2001-11-22
KR940013508A (ko) 1994-07-15
US5369113A (en) 1994-11-29
ZA939367B (en) 1994-08-08
KR100344328B1 (ko) 2002-11-29
ZA939366B (en) 1994-08-08
US5374636A (en) 1994-12-20
KR940013507A (ko) 1994-07-15
ZA939365B (en) 1994-08-08
KR100310663B1 (ko) 2002-06-20
US5444070A (en) 1995-08-22

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