DE69332366T2 - Arylsubstituierte heterocyclische Verbindungen - Google Patents

Arylsubstituierte heterocyclische Verbindungen

Info

Publication number
DE69332366T2
DE69332366T2 DE69332366T DE69332366T DE69332366T2 DE 69332366 T2 DE69332366 T2 DE 69332366T2 DE 69332366 T DE69332366 T DE 69332366T DE 69332366 T DE69332366 T DE 69332366T DE 69332366 T2 DE69332366 T2 DE 69332366T2
Authority
DE
Germany
Prior art keywords
substituted heterocyclic
heterocyclic compounds
aryl substituted
compounds
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332366T
Other languages
English (en)
Other versions
DE69332366D1 (de
Inventor
Peter Moldt
Joergen Scheel-Krueger
Leif Helth Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK921541A external-priority patent/DK154192D0/da
Priority claimed from DK71893A external-priority patent/DK71893D0/da
Priority claimed from US08/093,184 external-priority patent/US5554626A/en
Application filed by Neurosearch AS filed Critical Neurosearch AS
Application granted granted Critical
Publication of DE69332366D1 publication Critical patent/DE69332366D1/de
Publication of DE69332366T2 publication Critical patent/DE69332366T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
DE69332366T 1992-12-23 1993-12-20 Arylsubstituierte heterocyclische Verbindungen Expired - Lifetime DE69332366T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK921541A DK154192D0 (da) 1992-12-23 1992-12-23 Heterocycliske forbindelser
DK71893A DK71893D0 (da) 1993-06-18 1993-06-18 Heterocykliske forbindelser
US08/093,184 US5554626A (en) 1992-12-23 1993-07-16 Substituted heterocyclic compounds as dopamine-reuptake inhibitors

Publications (2)

Publication Number Publication Date
DE69332366D1 DE69332366D1 (de) 2002-11-14
DE69332366T2 true DE69332366T2 (de) 2003-06-18

Family

ID=27220884

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332366T Expired - Lifetime DE69332366T2 (de) 1992-12-23 1993-12-20 Arylsubstituierte heterocyclische Verbindungen

Country Status (9)

Country Link
EP (1) EP0604352B1 (de)
JP (1) JPH06293760A (de)
AT (1) ATE225787T1 (de)
AU (1) AU672644B2 (de)
CA (1) CA2112083C (de)
DE (1) DE69332366T2 (de)
FI (1) FI935799A (de)
NO (1) NO301227B1 (de)
NZ (1) NZ250514A (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329520B1 (en) * 1990-08-09 2001-12-11 Research Triangle Institute Cocaine receptor binding ligands
WO1997016451A1 (en) * 1995-11-02 1997-05-09 Neurosearch A/S Fused tropane-derivatives as neurotransmitter reuptake inhibitors
JP3238414B2 (ja) * 1996-02-22 2001-12-17 ニューロサーチ・アクティーゼルスカブ トロパン―誘導体、その製造方法及びその使用方法
JP2001505576A (ja) * 1996-12-02 2001-04-24 ジョージタウン ユニバーシティ トロパン誘導体類及びそれらの合成方法
GB9915617D0 (en) * 1999-07-05 1999-09-01 Knoll Ag Therapeutic agents
WO2003045388A1 (en) 2001-11-30 2003-06-05 Neurosearch A/S Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
MXPA06003762A (es) 2003-10-16 2006-06-14 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de recaptacion de neurotransmisor monoamina y un inhibidor de acetilcolinesterasa.
EP1779851A1 (de) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Behandlung von Diabetes
BRPI0716532A2 (pt) * 2006-09-11 2013-09-24 Glaxo Group Ltd compostos azabicÍclios como inidores de reabsorÇço de monoaminas
WO2010125033A1 (en) * 2009-04-29 2010-11-04 Glaxo Group Limited Azabicyclo[4.1.0]heptane derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
FR2276823A1 (fr) * 1974-07-04 1976-01-30 Roussel Uclaf Nouveaux derives de la dibenzo(b.e)thiepine et leurs sels, procede de preparation et application a titre de medicaments desdits produits
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
EP0398578B1 (de) * 1989-05-17 1997-03-12 Pfizer Inc. 2-Piperidino-1-alkanol-Derivate als antiischemische Wirkstoffe
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
EP0905135B1 (de) * 1991-11-15 2006-09-06 Research Triangle Institute Kokain-Rezeptor Bindungsliganden
US5262428A (en) * 1992-03-13 1993-11-16 Wake Forest University Biologically active tropane derivatives
US5268480A (en) * 1992-09-22 1993-12-07 Mayo Foundation For Medical Education And Research Cocaine analogs
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds

Also Published As

Publication number Publication date
AU5236393A (en) 1994-07-07
CA2112083A1 (en) 1994-06-24
FI935799A (fi) 1994-06-24
ATE225787T1 (de) 2002-10-15
NO934760D0 (no) 1993-12-22
AU672644B2 (en) 1996-10-10
FI935799A0 (fi) 1993-12-22
EP0604352A3 (de) 1995-02-08
JPH06293760A (ja) 1994-10-21
DE69332366D1 (de) 2002-11-14
NO301227B1 (no) 1997-09-29
CA2112083C (en) 2002-02-19
NO934760L (no) 1994-06-24
EP0604352A2 (de) 1994-06-29
EP0604352B1 (de) 2002-10-09
NZ250514A (en) 1996-03-26

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Legal Events

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