DE69332636D1 - Antidepressiv und gegen die Parkinsonsche Krankheit wirkende Verbindungen - Google Patents

Antidepressiv und gegen die Parkinsonsche Krankheit wirkende Verbindungen

Info

Publication number
DE69332636D1
DE69332636D1 DE69332636T DE69332636T DE69332636D1 DE 69332636 D1 DE69332636 D1 DE 69332636D1 DE 69332636 T DE69332636 T DE 69332636T DE 69332636 T DE69332636 T DE 69332636T DE 69332636 D1 DE69332636 D1 DE 69332636D1
Authority
DE
Germany
Prior art keywords
compounds
parkinsonian
antidepressant
chem
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332636T
Other languages
English (en)
Other versions
DE69332636T2 (de
Inventor
Peter Moldt
Jorgen Scheel-Krueger
Leif Helth Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK921541A external-priority patent/DK154192D0/da
Application filed by Neurosearch AS filed Critical Neurosearch AS
Application granted granted Critical
Publication of DE69332636D1 publication Critical patent/DE69332636D1/de
Publication of DE69332636T2 publication Critical patent/DE69332636T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Hydrogenated Pyridines (AREA)
DE69332636T 1992-12-23 1993-12-20 Antidepressiv und gegen die Parkinsonsche Krankheit wirkende Verbindungen Expired - Lifetime DE69332636T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK921541A DK154192D0 (da) 1992-12-23 1992-12-23 Heterocycliske forbindelser
US08/093,182 US5374636A (en) 1992-12-23 1993-07-16 2,3-trans-disubstituted tropane compounds which have useful pharmaceutical utility

Publications (2)

Publication Number Publication Date
DE69332636D1 true DE69332636D1 (de) 2003-02-20
DE69332636T2 DE69332636T2 (de) 2003-09-11

Family

ID=26065882

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332636T Expired - Lifetime DE69332636T2 (de) 1992-12-23 1993-12-20 Antidepressiv und gegen die Parkinsonsche Krankheit wirkende Verbindungen

Country Status (9)

Country Link
EP (1) EP0604354B1 (de)
JP (1) JP3841449B2 (de)
AT (1) ATE231147T1 (de)
AU (1) AU672052B2 (de)
CA (1) CA2112084C (de)
DE (1) DE69332636T2 (de)
FI (1) FI935800A (de)
NO (1) NO303578B1 (de)
NZ (1) NZ250515A (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU673265B2 (en) * 1993-05-18 1996-10-31 Wake Forest University Treatment process with biologically active tropane derivatives
UA49801C2 (uk) * 1994-04-19 2002-10-15 Нейросерч А/С Похідні тропан-2-альдоксиму, спосіб їх отримання, фармацевтична композиція, спосіб лікування
IL123583A (en) * 1995-10-13 2003-07-31 Neurosearch As 3-substituted -8-azabicyclo [3,2,1] oct-2-ene derivatives, their preparation and pharmaceutical compositions containing them
AU720358B2 (en) * 1996-02-22 2000-06-01 Neurosearch A/S Tropane-derivatives, their preparation and use
WO1999038866A1 (en) * 1998-01-28 1999-08-05 Neurosearch A/S 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled form and use of 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled and unlabelled form
CA2335336A1 (en) * 1998-06-19 1999-12-23 James Edmund Audia Inhibition of serotonin reuptake
ATE407124T1 (de) * 2000-01-11 2008-09-15 Molecular Insight Pharm Inc Polypharmacophore verbindungen
WO2003014114A2 (en) * 2001-08-08 2003-02-20 Neurosearch A/S Substituted amine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CA2458801A1 (en) * 2001-08-17 2003-02-27 President And Fellows Of Harvard College Therapeutic tropane compounds
ATE345135T1 (de) 2001-11-30 2006-12-15 Neurosearch As Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen
CN100551924C (zh) * 2003-02-12 2009-10-21 神经研究公司 8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途
WO2004072071A1 (en) * 2003-02-12 2004-08-26 Neurosearch A/S 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP2006517567A (ja) * 2003-02-12 2006-07-27 ニューロサーチ、アクティーゼルスカブ 新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
NZ547152A (en) 2003-10-16 2009-12-24 Neurosearch As Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor
WO2007028770A1 (en) * 2005-09-05 2007-03-15 Neurosearch A/S Monoamine neurotransmitter re-uptake inhibitors for neuroprotection in patients suffering from an advanced stage of a mental disease
EP1779851A1 (de) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Behandlung von Diabetes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
US3901892A (en) * 1973-12-14 1975-08-26 Sterling Drug Inc 1,3-ethanoindeno(2,1-c)-pyridines and 1,3-ethanobenz(g)isoquinolines
FR2276823A1 (fr) * 1974-07-04 1976-01-30 Roussel Uclaf Nouveaux derives de la dibenzo(b.e)thiepine et leurs sels, procede de preparation et application a titre de medicaments desdits produits
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
ES2098248T3 (es) * 1989-05-17 1997-05-01 Pfizer Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK0644775T3 (da) * 1991-11-15 2000-03-06 Nat Inst Health Kokainreceptorbindende ligander
US5262428A (en) * 1992-03-13 1993-11-16 Wake Forest University Biologically active tropane derivatives
US5268480A (en) * 1992-09-22 1993-12-07 Mayo Foundation For Medical Education And Research Cocaine analogs

Also Published As

Publication number Publication date
CA2112084C (en) 2002-06-11
NO934761D0 (no) 1993-12-22
DE69332636T2 (de) 2003-09-11
NO303578B1 (no) 1998-08-03
ATE231147T1 (de) 2003-02-15
NZ250515A (en) 1996-09-25
CA2112084A1 (en) 1994-06-24
EP0604354A2 (de) 1994-06-29
EP0604354A3 (de) 1995-02-08
AU672052B2 (en) 1996-09-19
JPH06293758A (ja) 1994-10-21
FI935800A0 (fi) 1993-12-22
JP3841449B2 (ja) 2006-11-01
NO934761L (no) 1994-06-24
EP0604354B1 (de) 2003-01-15
FI935800A (fi) 1994-06-24
AU5236293A (en) 1994-07-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition