HRP20181261T1 - Modulatori regulatora transmembranske provodljivosti cistične fibroze - Google Patents
Modulatori regulatora transmembranske provodljivosti cistične fibrozeInfo
- Publication number
- HRP20181261T1 HRP20181261T1 HRP20181261TT HRP20181261T HRP20181261T1 HR P20181261 T1 HRP20181261 T1 HR P20181261T1 HR P20181261T T HRP20181261T T HR P20181261TT HR P20181261 T HRP20181261 T HR P20181261T HR P20181261 T1 HRP20181261 T1 HR P20181261T1
- Authority
- HR
- Croatia
- Prior art keywords
- modulators
- cystic fibrosis
- fibrosis transmembrane
- conductance regulator
- transmembrane conductance
- Prior art date
Links
- 102000012605 Cystic Fibrosis Transmembrane Conductance Regulator Human genes 0.000 title 1
- 108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 title 1
Classifications
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US16213009P | 2009-03-20 | 2009-03-20 | |
EP10710748.4A EP2408749B1 (en) | 2009-03-20 | 2010-03-19 | Modulators of cystic fibrosis transmembrane conductance regulator |
PCT/US2010/028062 WO2010108155A1 (en) | 2009-03-20 | 2010-03-19 | Modulators of cystic fibrosis transmembrane conductance regulator |
Publications (1)
Publication Number | Publication Date |
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HRP20181261T1 true HRP20181261T1 (hr) | 2018-12-14 |
Family
ID=42136194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20181261TT HRP20181261T1 (hr) | 2009-03-20 | 2018-08-02 | Modulatori regulatora transmembranske provodljivosti cistične fibroze |
Country Status (22)
Country | Link |
---|---|
US (4) | US8614325B2 (hr) |
EP (1) | EP2408749B1 (hr) |
JP (3) | JP5636418B2 (hr) |
CN (1) | CN102361856A (hr) |
AU (1) | AU2010226393B2 (hr) |
BR (1) | BRPI1012549B8 (hr) |
CA (1) | CA2755969C (hr) |
CY (1) | CY1120593T1 (hr) |
DK (1) | DK2408749T3 (hr) |
ES (1) | ES2683633T3 (hr) |
HR (1) | HRP20181261T1 (hr) |
HU (1) | HUE038854T2 (hr) |
IL (1) | IL215261A (hr) |
LT (1) | LT2408749T (hr) |
MX (1) | MX2011009868A (hr) |
NZ (1) | NZ595151A (hr) |
PL (1) | PL2408749T3 (hr) |
PT (1) | PT2408749T (hr) |
RU (1) | RU2518897C2 (hr) |
SI (1) | SI2408749T1 (hr) |
WO (1) | WO2010108155A1 (hr) |
ZA (1) | ZA201106618B (hr) |
Families Citing this family (52)
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TWI735416B (zh) | 2014-10-06 | 2021-08-11 | 美商維泰克斯製藥公司 | 囊腫纖維化症跨膜傳導調節蛋白之調節劑 |
RU2749213C2 (ru) | 2014-10-07 | 2021-06-07 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе |
KR101721029B1 (ko) * | 2014-10-16 | 2017-03-29 | 연세대학교 산학협력단 | 인돌리지노[3,2-c]퀴놀린 유도체, 이의 약제학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 낭포성 섬유증 예방 또는 치료용 약학조성물 |
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AU2016327603B2 (en) | 2015-09-25 | 2021-04-22 | Vertex Pharmaceuticals (Europe) Limited | Deuterated CFTR potentiators |
AU2017223490B2 (en) | 2016-02-22 | 2021-07-22 | Mars, Incorporated | Pet food |
WO2018029336A1 (en) | 2016-08-12 | 2018-02-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for determining whether a subject was administered with an activator of the ppar beta/delta pathway. |
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JP2009521468A (ja) * | 2005-12-24 | 2009-06-04 | バーテックス ファーマシューティカルズ インコーポレイテッド | Abc輸送体の調節因子としてのキノリン−4−オン誘導体 |
EP1974212A1 (en) * | 2005-12-27 | 2008-10-01 | Vertex Pharmaceuticals Incorporated | Compounds useful in cftr assays and methods therewith |
DK3219705T3 (da) | 2005-12-28 | 2020-04-14 | Vertex Pharma | Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid |
JP5461405B2 (ja) * | 2007-09-14 | 2014-04-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症膜コンダクタンス制御因子の調節因子 |
AU2010226393B2 (en) * | 2009-03-20 | 2016-08-11 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
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