EA200970267A1 - ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ МНОЖЕСТВО МИНИ-ТАБЛЕТОК, СОДЕРЖАЩИХ ИНГИБИТОР ФАКТОРА Xa - Google Patents
ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ МНОЖЕСТВО МИНИ-ТАБЛЕТОК, СОДЕРЖАЩИХ ИНГИБИТОР ФАКТОРА XaInfo
- Publication number
- EA200970267A1 EA200970267A1 EA200970267A EA200970267A EA200970267A1 EA 200970267 A1 EA200970267 A1 EA 200970267A1 EA 200970267 A EA200970267 A EA 200970267A EA 200970267 A EA200970267 A EA 200970267A EA 200970267 A1 EA200970267 A1 EA 200970267A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical composition
- tablets containing
- mini tablets
- inhibitor factor
- mini
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Фармацевтическая композиция модифицированного высвобождения для перорального введения, множество минитаблеток, включающих терапевтически эффективное количество ингибитора фактора Ха внутри матрицы из полимера (полимеров). Минитаблетки могут быть инкапсулированы внутрь желатиновой капсулы. Описаны также способ изготовления и способ применения.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82531406P | 2006-09-12 | 2006-09-12 | |
PCT/EP2007/059443 WO2008031782A1 (en) | 2006-09-12 | 2007-09-10 | Pharmaceutical composition comprising a plurality of mini-tablets comprising a factor xa inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200970267A1 true EA200970267A1 (ru) | 2009-08-28 |
Family
ID=38835794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970267A EA200970267A1 (ru) | 2006-09-12 | 2007-09-10 | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ МНОЖЕСТВО МИНИ-ТАБЛЕТОК, СОДЕРЖАЩИХ ИНГИБИТОР ФАКТОРА Xa |
Country Status (16)
Country | Link |
---|---|
US (1) | US20090285887A1 (ru) |
EP (1) | EP2061439A1 (ru) |
JP (1) | JP2010502762A (ru) |
KR (1) | KR20090052346A (ru) |
CN (1) | CN101516355A (ru) |
AR (1) | AR062721A1 (ru) |
AU (1) | AU2007296311A1 (ru) |
BR (1) | BRPI0716234A2 (ru) |
CA (1) | CA2662542A1 (ru) |
CL (1) | CL2007002618A1 (ru) |
EA (1) | EA200970267A1 (ru) |
IL (1) | IL197295A0 (ru) |
MX (1) | MX2009002669A (ru) |
PE (1) | PE20080661A1 (ru) |
TW (1) | TW200824723A (ru) |
WO (1) | WO2008031782A1 (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2685724C2 (ru) * | 2010-02-25 | 2019-04-23 | Бристол-Майерс Сквибб Холдингс Айрлэнд | Композиции апиксабана |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
NZ587547A (en) | 2004-06-24 | 2012-09-28 | Vertex Pharma | Modulators of ATP-Binding Cassette Transporters |
PL3219705T3 (pl) | 2005-12-28 | 2020-08-10 | Vertex Pharmaceuticals Incorporated | Kompozycje farmaceutyczne amorficznych postaci n-[2,4-bis(1,1-dimetyloetylo)-5-hydroksyfenylo]-1,4-dihydro-4-oksochinolino-3-karboksyamidu |
NZ624460A (en) | 2009-03-20 | 2015-12-24 | Vertex Pharma | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
EP2442791B1 (en) * | 2009-06-16 | 2019-11-27 | Pfizer Inc. | Dosage forms of apixaban |
WO2010151745A1 (en) * | 2009-06-25 | 2010-12-29 | Elite Laboratories, Inc. | Oral dosage forms |
AU2015271995A1 (en) * | 2010-02-25 | 2016-01-21 | Bristol-Myers Squibb Holdings Ireland | Apixaban formulations |
EP2608775A2 (en) * | 2010-08-27 | 2013-07-03 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
CA2814825C (en) | 2010-10-15 | 2016-11-22 | Lgch, Inc. | Method and apparatus for detecting seizures |
EP2554159A1 (en) * | 2011-08-04 | 2013-02-06 | ratiopharm GmbH | Dosage forms comprising apixaban and content uniformity enhancer |
IL265430B1 (en) | 2012-02-27 | 2024-04-01 | Vertex Pharma | Pharmaceutical preparations containing a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide and uses thereof |
KR101378973B1 (ko) * | 2012-04-13 | 2014-03-28 | 한미약품 주식회사 | 구형에 가까운 형태의 다중 투여 단위 정제를 포함하는 경질 캡슐 복합 제형 및 이의 제조방법 |
CA2873949A1 (en) * | 2012-05-24 | 2013-11-28 | Ratiopharm Gmbh | Dosage forms comprising apixaban and matrix former |
WO2014033077A1 (en) | 2012-08-28 | 2014-03-06 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Composition comprising an antibiotic and a beta-lactamase inhibitor, wherein at| least one of them is in the form of mini-tablets |
CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
CA3015607A1 (en) * | 2016-02-25 | 2017-08-31 | Mylan Inc. | A unique high-shear granulation process for improved bioavailability of rivaroxaban |
KR20190130411A (ko) | 2018-05-14 | 2019-11-22 | 신일제약주식회사 | 아픽사반 약제학적 제제 및 그의 제조방법 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002537321A (ja) * | 1999-02-22 | 2002-11-05 | エラン コーポレイション ピーエルスィー | 促進剤を含む固体経口剤形 |
WO2000048589A1 (en) * | 1999-02-22 | 2000-08-24 | Emisphere Holdings, Inc. | Solid oral dosage form containing heparin or a heparinoid in combination with a carrier |
US6794412B1 (en) * | 1999-03-11 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Treatment of thrombosis by combined use of a factor Xa inhibitor and aspirin |
GB0114004D0 (en) * | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
AR040680A1 (es) * | 2002-07-25 | 2005-04-13 | Pharmacia Corp | Composicion de tabletas de liberacion sostenida |
KR20040076203A (ko) * | 2003-02-24 | 2004-08-31 | 주식회사 엘지생명과학 | 음식물-약물 상호작용을 방지하기 위한 경구 투여용약제학적 조성물 및 방법 |
DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
-
2007
- 2007-09-10 TW TW096133641A patent/TW200824723A/zh unknown
- 2007-09-10 BR BRPI0716234-0A patent/BRPI0716234A2/pt not_active IP Right Cessation
- 2007-09-10 WO PCT/EP2007/059443 patent/WO2008031782A1/en active Application Filing
- 2007-09-10 CL CL200702618A patent/CL2007002618A1/es unknown
- 2007-09-10 CA CA002662542A patent/CA2662542A1/en not_active Abandoned
- 2007-09-10 AU AU2007296311A patent/AU2007296311A1/en not_active Abandoned
- 2007-09-10 EA EA200970267A patent/EA200970267A1/ru unknown
- 2007-09-10 CN CNA2007800338980A patent/CN101516355A/zh active Pending
- 2007-09-10 JP JP2009527796A patent/JP2010502762A/ja not_active Withdrawn
- 2007-09-10 EP EP07803361A patent/EP2061439A1/en not_active Withdrawn
- 2007-09-10 KR KR1020097005035A patent/KR20090052346A/ko not_active Application Discontinuation
- 2007-09-10 US US12/440,740 patent/US20090285887A1/en not_active Abandoned
- 2007-09-10 AR ARP070103983A patent/AR062721A1/es unknown
- 2007-09-10 MX MX2009002669A patent/MX2009002669A/es not_active Application Discontinuation
- 2007-09-10 PE PE2007001213A patent/PE20080661A1/es not_active Application Discontinuation
-
2009
- 2009-02-26 IL IL197295A patent/IL197295A0/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2685724C2 (ru) * | 2010-02-25 | 2019-04-23 | Бристол-Майерс Сквибб Холдингс Айрлэнд | Композиции апиксабана |
Also Published As
Publication number | Publication date |
---|---|
AU2007296311A1 (en) | 2008-03-20 |
TW200824723A (en) | 2008-06-16 |
PE20080661A1 (es) | 2008-06-12 |
US20090285887A1 (en) | 2009-11-19 |
CL2007002618A1 (es) | 2008-03-14 |
KR20090052346A (ko) | 2009-05-25 |
AR062721A1 (es) | 2008-11-26 |
BRPI0716234A2 (pt) | 2013-10-15 |
EP2061439A1 (en) | 2009-05-27 |
MX2009002669A (es) | 2009-03-24 |
JP2010502762A (ja) | 2010-01-28 |
CA2662542A1 (en) | 2008-03-20 |
CN101516355A (zh) | 2009-08-26 |
WO2008031782A1 (en) | 2008-03-20 |
IL197295A0 (en) | 2009-12-24 |
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