ES2040856T3 - Un procedimiento para preparar un compuesto de tiofeno. - Google Patents

Un procedimiento para preparar un compuesto de tiofeno.

Info

Publication number
ES2040856T3
ES2040856T3 ES198888305744T ES88305744T ES2040856T3 ES 2040856 T3 ES2040856 T3 ES 2040856T3 ES 198888305744 T ES198888305744 T ES 198888305744T ES 88305744 T ES88305744 T ES 88305744T ES 2040856 T3 ES2040856 T3 ES 2040856T3
Authority
ES
Spain
Prior art keywords
preparing
procedure
integer
thiophene compound
zero
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888305744T
Other languages
English (en)
Inventor
Kimiaki Hayashi
Yasuhiko Ozaki
Kenji Yamada
Hideyuki Takenaga
Ichizo Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2040856T3 publication Critical patent/ES2040856T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C07D333/10—Thiophene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Dowels (AREA)
  • Joining Of Building Structures In Genera (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE DESCRIBE UN DERIVADO DE TIOFENO DE FORMULA (I), DONDE R1, R2 Y R3 SON UN GRUO ALQUENILO INFERIOR; EL ANILLO A ES UN GRUPO FENILO SUSTITUIDO O SIN SUSTITUIR; X ES -OCO-, -O- O -S-; M Y N SON 0 O 1; Y P Y Q SON 0, 1 O 2, O UNA DE SUS SALES, Y PROCEDIMIENTO PARA OBTENERLO. EL DERIVADO DE TIOFENO (I) ES UTIL COMO REGULADOR DE LA MOTILIDAD DEL TRACTO INTESTINAL. TAMBIEN SE DESCRIBEN METODOS PARA PREPARAR LOS COMPUESTOS NUEVOS, Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
ES198888305744T 1987-06-30 1988-06-23 Un procedimiento para preparar un compuesto de tiofeno. Expired - Lifetime ES2040856T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16483787 1987-06-30

Publications (1)

Publication Number Publication Date
ES2040856T3 true ES2040856T3 (es) 1993-11-01

Family

ID=15800866

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888305744T Expired - Lifetime ES2040856T3 (es) 1987-06-30 1988-06-23 Un procedimiento para preparar un compuesto de tiofeno.

Country Status (16)

Country Link
US (1) US4857543A (es)
EP (1) EP0297782B1 (es)
JP (1) JPS6479175A (es)
KR (1) KR890000457A (es)
CN (1) CN1021051C (es)
AT (1) ATE63746T1 (es)
AU (1) AU599495B2 (es)
CA (1) CA1320964C (es)
DE (1) DE3862901D1 (es)
DK (1) DK358088A (es)
ES (1) ES2040856T3 (es)
FI (1) FI882873A (es)
FR (1) FR2617402B1 (es)
GR (1) GR3001994T3 (es)
HU (1) HU203338B (es)
IL (1) IL86740A (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
FR2658817B1 (fr) * 1990-02-28 1993-02-05 Jouveinal Sa Ethylamines substituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese.
EP0446097A1 (fr) * 1990-02-26 1991-09-11 Jouveinal S.A. Ethylamines substituées, leur procédé de préparation, leur utilisation comme médicament et leurs intermédiaires de synthèse
CA2037114C (en) * 1990-02-26 2003-09-09 Jouveinal N-cycloalkylalkylamines, their process of preparation, their use as medication and their synthetic intermediates
FR2658822A1 (fr) * 1990-02-28 1991-08-30 Jouveinal Sa N-cycloalkylalkylamines, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese.
IE913279A1 (en) * 1990-09-26 1992-04-08 Astra Ab (2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties
JPH06509090A (ja) * 1991-07-10 1994-10-13 メルク　シヤープ　エンド　ドーム　リミテツド 芳香族化合物、それらを含む組成物、及び治療におけるそれらの使用
GB9211193D0 (en) * 1992-05-27 1992-07-08 Merck Sharp & Dohme Therapeutic agents
CN100415735C (zh) * 2000-07-13 2008-09-03 三共株式会社 氨基醇衍生物
MXPA03000397A (es) 2000-07-13 2003-05-27 Sankyo Co Derivados de aminoalcohol.
BR0306811A (pt) 2002-01-11 2004-10-26 Sankyo Co Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero
KR20110136901A (ko) 2004-02-24 2011-12-21 상꾜 가부시키가이샤 아미노 알코올 화합물
CN110407703A (zh) * 2019-08-02 2019-11-05 深圳振强生物技术有限公司 吲哚布芬杂质的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3122561A (en) * 1959-10-19 1964-02-25 Tuskegee Inst 1-(2-thenyl)-2-di-lower alkylaminoethyl diphenylacetate and related compounds
GB1343527A (en) * 1971-07-30 1974-01-10 Cerm Cent Europ Rech Mauvernay Amino-propanol derivatives
US4128551A (en) * 1976-12-06 1978-12-05 The Dow Chemical Co. Substituted pyridine carboxyl halides and derivatives
JPS58105946A (ja) * 1981-12-18 1983-06-24 Tanabe Seiyaku Co Ltd アミノブタノ−ルエステル誘導体の製法

Also Published As

Publication number Publication date
DE3862901D1 (de) 1991-06-27
EP0297782B1 (en) 1991-05-22
FI882873A0 (fi) 1988-06-16
FI882873A (fi) 1988-12-31
IL86740A (en) 1992-11-15
GR3001994T3 (en) 1992-11-23
HUT50160A (en) 1989-12-28
DK358088D0 (da) 1988-06-29
AU1853488A (en) 1989-01-05
AU599495B2 (en) 1990-07-19
KR890000457A (ko) 1989-03-14
JPH0546343B2 (es) 1993-07-13
EP0297782A1 (en) 1989-01-04
IL86740A0 (en) 1988-11-30
CN1021051C (zh) 1993-06-02
JPS6479175A (en) 1989-03-24
FR2617402A1 (fr) 1989-01-06
CN1030584A (zh) 1989-01-25
US4857543A (en) 1989-08-15
FR2617402B1 (fr) 1991-07-12
HU203338B (en) 1991-07-29
CA1320964C (en) 1993-08-03
DK358088A (da) 1988-12-31
ATE63746T1 (de) 1991-06-15

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