KR890000457A - 티오펜 유도체 - Google Patents

티오펜 유도체 Download PDF

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Publication number
KR890000457A
KR890000457A KR1019880007901A KR880007901A KR890000457A KR 890000457 A KR890000457 A KR 890000457A KR 1019880007901 A KR1019880007901 A KR 1019880007901A KR 880007901 A KR880007901 A KR 880007901A KR 890000457 A KR890000457 A KR 890000457A
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KR
South Korea
Prior art keywords
phenyl
formula
ring
compound
methoxyphenyl
Prior art date
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KR1019880007901A
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English (en)
Inventor
기미아끼 하야시
야스히꼬 오자끼
겐지 야마다
히데유끼 다께나가
이찌조오 이노우에
Original Assignee
아다찌 게이지로오
다나베 세이야꾸 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 아다찌 게이지로오, 다나베 세이야꾸 가부시기가이샤 filed Critical 아다찌 게이지로오
Publication of KR890000457A publication Critical patent/KR890000457A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C07D333/10—Thiophene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Dowels (AREA)
  • Joining Of Building Structures In Genera (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

티오펜 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
내용 없음

Claims (9)

  1. 일반식(I)의 티오펜 유도체 또는 그 염
    위의 일반식에서, R1, R2및 R3은 저급알킬이고, 환 A는 치환 또는 비치환 페닐이고, X는 -OCO-, -O- 또는 -S-이고, m 및 N은 0 또는 1의 정수이고, p 및 q는 0,1 또는 2의 정수이다.
  2. 제1항에 있어서, 환 A가 페닐, 저급알킬렌디옥시-치환된 페닐; 저급알킬, 저급알킬티오, 저급알콕시, 페닐저급알콕시, 저급알콕시카르보닐, 할로겐원자, 아미노 및 히드록시로 이루어진 그룹으로부터 선택한 1 내지 3의 기로 치환된 페닐인 일반식(I)의 티오펜 유도체 또는 그 염.
  3. 제1항에 있어서, R1, R2및 R3이 메틸 또는 에틸이고, 환 A가 페닐, 메틸렌디옥시-치환된 페닐이거나, 메틸, n-프로필, 3급-부틸, 메틸티오, 메톡시, 벤질옥시, 메톡시카르보닐, 클로린, 아미노 및 히드록시로 이루어진 그룹으로부터 선택한 1 내지 3의 기로 치환된 페닐인 일반식(I)의 티오펜 유도체 또는 그 염.
  4. 제3항에 있어서, 환 A가 페닐, 3,4-메틸렌디옥시페닐, 4-메틸페닐, 4-메틸티오페닐, 3-메톡시페닐, 4-메톡시페닐, 2,4-디메톡시페닐, 3,4-디메톡시페닐, 2,3,4-트리메톡시페닐, 3,4,5-트리메톡시페닐, 2-벤질옥시-3-메톡시페닐, 2-메톡시-5-메톡시카르보닐페닐, 3-메톡시-2-n-프로필페닐, 3,5-2(3급)-부틸-4-히드록시페닐, 4-히드록시-3,5-디메톡시페닐 또는 4-클로로페닐, 2-클로로-5-메톡시페닐, 4-클로로-3-메톡시페닐, 5-클로로-2-메톡시페닐 또는 4-아미노-3-클로로-2-메톡시페닐인 일반식(I)의 티오펜 유도체 또는 그의 염.
  5. 제3항에 있어서, R1이 에틸이고, R2및 R3이 메틸이고, 환 A가 3,4,5-트리메톡시페닐 또는 4-히드록시-3,5-디메톡시페닐인 일반식(I)의 티오펜 유도체 또는 그 염.
  6. 제3항에 있어서, R1이 에틸이고, R2및 R3이 메틸이고, 환 A가 3,4,5-트리메톡시페닐 또는 0이고, P가 1 또는 2이고, q가 0 또는 1인 일반식(I)의 티오펜 유도체 또는 그 염.
  7. 제6항에 있어서, 1-(4-히드록시-3,5-디메톡시벤질옥시메틸)-1-(2-티에닐)-N, N-디메틸프로필아민인 일반식(I)의 화합물 또는 그 염.
  8. [I] A) 일반식(II)의 아민을 알킬화 반응시키거나, B) 일반식(III)의 아미노알킬은 화합물을 일반식(IV)의 카르복시산 유도체 또는 그 반응성 유도체와 축합반응시키거나, C) 일반식(III)의 아미노알칸을 화합물을 일반식(V)의 화합물과 반응시키거나, [II] 생성물의 환 A가 3,4,5-트리(저급알콕시)페닐일 경우 이를 4-히드록시-3,5-디(저급알콕시)페닐로 탈알킬화하여, 일반식(I)의 티오펜유도체 또는 그 염을 제조하는 방법.
    위의 일반식에서, R1, R2및 R3은 저급알킬이고, 환 A은 페닐 또는 치환된 페닐이고 X는 -OCO-, -O- 또는 -S-이고, m 및 n은 0 또는 1이고, p 및 q는 0,1 또는 2이고, Y는 반응성 잔기이다.
  9. 일반식(I)의 화합물을 치료효과량 함유하고 약제학적 담체로 조성된 약제조성물.
    위의 일반식에서, R1, R2및 R3은 저급알킬이고, 환 A는 치환 또는 비치환 페닐이고, X는 -OCO-, -O- 또는 -S-이고, m 및 n은 0 또는 1의 정수이고, p 및 q는 0,1 또는 2의 정수이다.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880007901A 1987-06-30 1988-06-29 티오펜 유도체 KR890000457A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16483787 1987-06-30
JP62-164837 1987-06-30

Publications (1)

Publication Number Publication Date
KR890000457A true KR890000457A (ko) 1989-03-14

Family

ID=15800866

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880007901A KR890000457A (ko) 1987-06-30 1988-06-29 티오펜 유도체

Country Status (16)

Country Link
US (1) US4857543A (ko)
EP (1) EP0297782B1 (ko)
JP (1) JPS6479175A (ko)
KR (1) KR890000457A (ko)
CN (1) CN1021051C (ko)
AT (1) ATE63746T1 (ko)
AU (1) AU599495B2 (ko)
CA (1) CA1320964C (ko)
DE (1) DE3862901D1 (ko)
DK (1) DK358088A (ko)
ES (1) ES2040856T3 (ko)
FI (1) FI882873A (ko)
FR (1) FR2617402B1 (ko)
GR (1) GR3001994T3 (ko)
HU (1) HU203338B (ko)
IL (1) IL86740A (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
FR2658817B1 (fr) * 1990-02-28 1993-02-05 Jouveinal Sa Ethylamines substituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese.
FR2658822A1 (fr) * 1990-02-28 1991-08-30 Jouveinal Sa N-cycloalkylalkylamines, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese.
FI97384C (fi) * 1990-02-26 1996-12-10 Jouveinal Sa Menetelmä terapeuttisesti käyttökelpoisten N-sykloalkyylialkyyliamiinien valmistamiseksi
CA2037123A1 (en) * 1990-02-26 1991-08-27 Jouveinal S.A. Substituted ethylamines, their process of preparation, their use as medication and their synthetic intermediates
IE913279A1 (en) * 1990-09-26 1992-04-08 Astra Ab (2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties
CA2110725A1 (en) * 1991-07-10 1993-01-21 Andrew P. Owens Aromatic compounds, compositions containing them and their use in therapy
GB9211193D0 (en) * 1992-05-27 1992-07-08 Merck Sharp & Dohme Therapeutic agents
CN100415735C (zh) * 2000-07-13 2008-09-03 三共株式会社 氨基醇衍生物
NZ523554A (en) * 2000-07-13 2004-12-24 Sankyo Co Amino alcohol derivatives
PL211954B1 (pl) 2002-01-11 2012-07-31 Sankyo Co Związek, kompozycja farmaceutyczna oraz zastosowanie kompozycji farmaceutycznej
EP1733724A4 (en) 2004-02-24 2010-07-07 Sankyo Co Aminoalcohol compound
CN110407703A (zh) * 2019-08-02 2019-11-05 深圳振强生物技术有限公司 吲哚布芬杂质的制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3122561A (en) * 1959-10-19 1964-02-25 Tuskegee Inst 1-(2-thenyl)-2-di-lower alkylaminoethyl diphenylacetate and related compounds
GB1343527A (en) * 1971-07-30 1974-01-10 Cerm Cent Europ Rech Mauvernay Amino-propanol derivatives
US4128551A (en) * 1976-12-06 1978-12-05 The Dow Chemical Co. Substituted pyridine carboxyl halides and derivatives
JPS58105946A (ja) * 1981-12-18 1983-06-24 Tanabe Seiyaku Co Ltd アミノブタノ−ルエステル誘導体の製法

Also Published As

Publication number Publication date
EP0297782B1 (en) 1991-05-22
HU203338B (en) 1991-07-29
CN1021051C (zh) 1993-06-02
US4857543A (en) 1989-08-15
GR3001994T3 (en) 1992-11-23
DK358088A (da) 1988-12-31
AU599495B2 (en) 1990-07-19
CN1030584A (zh) 1989-01-25
EP0297782A1 (en) 1989-01-04
AU1853488A (en) 1989-01-05
ES2040856T3 (es) 1993-11-01
FR2617402A1 (fr) 1989-01-06
DK358088D0 (da) 1988-06-29
FI882873A0 (fi) 1988-06-16
IL86740A (en) 1992-11-15
CA1320964C (en) 1993-08-03
DE3862901D1 (de) 1991-06-27
JPS6479175A (en) 1989-03-24
HUT50160A (en) 1989-12-28
JPH0546343B2 (ko) 1993-07-13
IL86740A0 (en) 1988-11-30
FR2617402B1 (fr) 1991-07-12
ATE63746T1 (de) 1991-06-15
FI882873A (fi) 1988-12-31

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