KR830010072A - 아미디노 피페리딘 유도체의 제조방법 - Google Patents

아미디노 피페리딘 유도체의 제조방법 Download PDF

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Publication number
KR830010072A
KR830010072A KR1019820002310A KR820002310A KR830010072A KR 830010072 A KR830010072 A KR 830010072A KR 1019820002310 A KR1019820002310 A KR 1019820002310A KR 820002310 A KR820002310 A KR 820002310A KR 830010072 A KR830010072 A KR 830010072A
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South Korea
Prior art keywords
formula
compound
group
alkyl
phenyl
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KR1019820002310A
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English (en)
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KR880002273B1 (ko
Inventor
무쯔미 무라마쯔
도시오 사또
히로야수 에끼네
아쯔시 덴도오
요시오 기가와
가나메 곤도오
Original Assignee
야마구찌 아끼라
닛뽕 케미파 가부시기 가이샤
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Priority claimed from JP56078142A external-priority patent/JPS57193457A/ja
Priority claimed from JP7814381A external-priority patent/JPS57193456A/ja
Priority claimed from JP13085681A external-priority patent/JPS5832865A/ja
Application filed by 야마구찌 아끼라, 닛뽕 케미파 가부시기 가이샤 filed Critical 야마구찌 아끼라
Publication of KR830010072A publication Critical patent/KR830010072A/ko
Application granted granted Critical
Publication of KR880002273B1 publication Critical patent/KR880002273B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

이미디노 피페리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 일반식(Ⅲ)의 화합물을 알킬 이소우레아 또는 알킬 이소티오우레아와 반응시킴을 특징으로 하여 일반식(Ⅱ)의 화합물 또는 그의 염을 제조하는 방법.
    상기식중 m은 1내지 3의 정수를 나타낸다.
  2. 일반식(Ⅳ)의 화합물 또는 그의 반응성 유도체를 일반식(Ⅵ)의 화합물 또는 그의 아황산염 유도체와 반응시키고, 따라서 수득된 R″가 벤질옥시카보닐페닐 또는 디페닐메틸옥시카보닐 비닐페닐그룹인 화합물을 촉매적으로 활성화된 수소로 수소화하여 R′가 카복실페닐 또는 카복시비닐페닐 그룹인 상응하는 화합물로 전환시킴을 특징으로 하여 일반식(Ⅰb)의 화합물 또는 그의 약제학적으로 허용되는 염을 제조하는 방법.
    R″-A-H (Ⅵ)
    상기 식에서 R′는 나프틸, 인다닐, 테트라하이드로나프틸 또는 피리딜기룹 또는 할로겐원자 및 알킬, 알케닐, 알콕시, 알카노일, 시아노, 포르밀, 트리플루오로메틸, 페닐, 페닐알킬, 알카노일아미노, 아미노-설포닐, 카복실, 알콕시카보닐, 벤질옥시카보닐, 벤조일비닐, 페닐비닐가보닐, 카복시비닐 및 디페닐메틸옥시카보닐비닐 그룹으로 구성되는 그룹중에서 선택된 1 내지 3개의 치환체를 가질 수 있는 페닐그룹이며, n은 0내지 3의 정수를 나타내고, R″는 나프틸, 인다닐, 테트라하이드로나프틸 또는 피리딜그룹 또는 할로겐원자 및 알킬, 알케닐, 알콕시, 알카노일, 시아노, 포르밀, 트리플루오로메틸, 페닐, 페닐알킬, 알카노일아미노, 아미노-설포닐, 알콕시카보닐, 벤질옥시카보닐, 벤질일비닐, 페닐비닐카보닐 및 디페닐메틸옥시카보닐비닐 그룹으로 구성되는 그룹중에서 선택된 1 내지 3개의 치환체를 가질 수 있는 페닐그룹이며, A는 산소 또는 황원자를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8202310A 1981-05-25 1982-05-25 아미디노 피페리딘 유도체의 제조방법 KR880002273B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP78142/1981 1981-05-25
JP56078142A JPS57193457A (en) 1981-05-25 1981-05-25 Amidinopiperidine derivative and its preparation
JP7814381A JPS57193456A (en) 1981-05-25 1981-05-25 Novel amidinopiperidine derivative and its preparation
JP78143/1981 1981-05-25
JP13085681A JPS5832865A (ja) 1981-08-22 1981-08-22 新規なアミジノピペリジン誘導体およびその製造法
JP130856/1981 1981-08-22

Publications (2)

Publication Number Publication Date
KR830010072A true KR830010072A (ko) 1983-12-26
KR880002273B1 KR880002273B1 (ko) 1988-10-21

Family

ID=27302625

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8202310A KR880002273B1 (ko) 1981-05-25 1982-05-25 아미디노 피페리딘 유도체의 제조방법

Country Status (12)

Country Link
US (1) US4433152A (ko)
KR (1) KR880002273B1 (ko)
AR (1) AR242560A1 (ko)
BR (1) BR8203060A (ko)
CA (1) CA1188302A (ko)
CH (1) CH654298A5 (ko)
DE (1) DE3219614A1 (ko)
ES (1) ES8307218A1 (ko)
FR (1) FR2506306B1 (ko)
IT (1) IT1157014B (ko)
MX (1) MX158198A (ko)
NL (1) NL8202109A (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139357A (ja) * 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
FR2603583B1 (fr) * 1986-09-05 1988-12-09 Andre Buzas Derives de la benzhydryloxyethyl-piperidine, procede d'obtention et compositions pharmaceutiques les contenant
IT1231238B (it) * 1987-09-21 1991-11-26 Angeli Inst Spa Derivati ammidinici
TW201303B (ko) * 1990-07-05 1993-03-01 Hoffmann La Roche
AU2915892A (en) * 1991-11-14 1993-06-15 Glaxo Group Limited Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
EP0623120A1 (en) * 1992-01-21 1994-11-09 Glaxo Group Limited Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
TW223629B (ko) * 1992-03-06 1994-05-11 Hoffmann La Roche
TW394760B (en) * 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
US5637599A (en) * 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
US5932733A (en) * 1994-06-17 1999-08-03 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
US5658930A (en) * 1994-12-13 1997-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US5792769A (en) * 1995-09-29 1998-08-11 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
BR9610876A (pt) * 1995-09-29 1999-07-13 Dimensional Pharm Inc Inibidores de protease de guanidino
DE69631692T2 (de) * 1995-12-29 2004-12-02 3-Dimensional Pharmaceuticals, Inc. Amidino proteaseinhibitoren
US6756389B2 (en) * 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
JP4247415B2 (ja) 1996-10-07 2009-04-02 広栄化学工業株式会社 γ―（ピペリジル）酪酸の酸塩の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3189601A (en) * 1964-01-10 1965-06-15 Ciba Geigy Corp N, n-alkylene-imino-lower alkanoamidine compounds
US3933797A (en) * 1972-02-22 1976-01-20 Pfizer Inc. 6-[α-(ω-QUANIDINOALKANOYLAMIDO)ACYLAMIDO]PENICILLANIC ACIDS
US3979398A (en) * 1973-02-08 1976-09-07 Smith Kline & French Laboratories Limited Sulphoxides
US3972872A (en) * 1974-09-23 1976-08-03 Pfizer Inc. 6-[α-(ω-Guanidinoalkanoylamido)acylamido]penicillanic acids

Also Published As

Publication number Publication date
FR2506306A1 (fr) 1982-11-26
IT1157014B (it) 1987-02-11
FR2506306B1 (fr) 1985-12-06
US4433152A (en) 1984-02-21
NL8202109A (nl) 1982-12-16
ES512519A0 (es) 1983-07-01
MX158198A (es) 1989-01-16
CH654298A5 (fr) 1986-02-14
CA1188302A (en) 1985-06-04
DE3219614A1 (de) 1982-12-23
ES8307218A1 (es) 1983-07-01
KR880002273B1 (ko) 1988-10-21
IT8267668A0 (it) 1982-05-24
BR8203060A (pt) 1983-05-10
DE3219614C2 (ko) 1990-10-04
AR242560A1 (es) 1993-04-30

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