KR850006934A - 3-페닐-2-프로펜아민 유도체의 제법 - Google Patents
3-페닐-2-프로펜아민 유도체의 제법 Download PDFInfo
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- KR850006934A KR850006934A KR1019850000935A KR850000935A KR850006934A KR 850006934 A KR850006934 A KR 850006934A KR 1019850000935 A KR1019850000935 A KR 1019850000935A KR 850000935 A KR850000935 A KR 850000935A KR 850006934 A KR850006934 A KR 850006934A
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- South Korea
- Prior art keywords
- formula
- alkyl
- defined above
- hydrogen
- radical
- Prior art date
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- RDAFNSMYPSHCBK-UHFFFAOYSA-N 3-phenylprop-2-en-1-amine Chemical class NCC=CC1=CC=CC=C1 RDAFNSMYPSHCBK-UHFFFAOYSA-N 0.000 title claims 2
- 125000000217 alkyl group Chemical group 0.000 claims abstract 22
- 150000001875 compounds Chemical class 0.000 claims abstract 13
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 8
- 229910052736 halogen Inorganic materials 0.000 claims abstract 7
- 150000002367 halogens Chemical class 0.000 claims abstract 7
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 6
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract 6
- 125000004663 dialkyl amino group Chemical group 0.000 claims abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract 5
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims abstract 4
- 125000004414 alkyl thio group Chemical group 0.000 claims abstract 4
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims abstract 4
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 3
- 125000001424 substituent group Chemical group 0.000 claims abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims abstract 2
- 125000005842 heteroatom Chemical group 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 230000003287 optical effect Effects 0.000 claims abstract 2
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 2
- 125000004076 pyridyl group Chemical group 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 150000002431 hydrogen Chemical group 0.000 claims 11
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 7
- 239000011593 sulfur Chemical group 0.000 claims 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 4
- 150000001412 amines Chemical class 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 229910021529 ammonia Inorganic materials 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 claims 1
- -1 amino, Phenyl Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004852 dihydrofuranyl group Chemical group O1C(CC=C1)* 0.000 claims 1
- 150000002148 esters Chemical group 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- 150000002680 magnesium Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/21—Monoamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
내용 없음
Description
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Claims (1)
- 하기 방법 (1)-(9)로 구성된 하기 일반식(Ⅰ)의 3-페닐-2-프로펜아민 및 그의 제약상 허용되는 염의 제조방법.(Ⅰ)상기식에서, R은 수소, 할로겐, 알킬, 알킬옥시, 알킬티오, 아미노, 알킬아미노, 디알킬아미노 또는 트리플루오로메틸을 나타내며, R3는 수소 또는 알킬을 나타내며; -R4와 R5는 각기 수소를 나타내며, R1과 R2는 동일 또는 상이한 것으로 각기 수소나 또는 C2-4알케닐에 의해 치환되거나 비치환된 알킬을 나타내거나 또는 R1과 R2는 그들이 결합되어 있는 질소원자와 함께 일킬에 의해 치환되거나 비치환된, 산소, 유황 또는 질소와 같은 다른 헤테로원자를 임의로 함유하는 4-7개의 환원자를 가진 포화헤테로고리라디칼을 나타내며; 또는 -R4는 수소를 나타내고 R1은 수소 또는 알킬을 나타내며 R2과 R5는 함께 C3-4알킬렌라디칼을 형성하며 (i) A는 할로겐, 알킬, 알킬옥시, 알킬티오, 아미노, 알킬아미노, 디알킬아미노, 니트로 및 트리플루오로메틸로 부터 선택된 하나 또는 2개의 치환분에 의해 치환되거나 비치환된 페닐 또는 알킬을 나타내거나 또는 A는 피리딜, 벤질 또는 C3-6사이클로알킬을 나타내며, Y는 유황, 설피닐,설포닐 또는 하기구조(Ⅱ)의 라디칼을 나타내며,(Ⅱ)(여기서, R6는 수소 또는 알킬을 나타내며, R7은 수소 또는 알킬카보닐, 알킬옥시카보닐, 알킬아미노카보닐, 또는 벤조일을 나타내며 이것은 할로겐, 알킬, 알킬옥시, 일킬티오, 아미노, 알킬아미노, 디알킬아미노, 니트로 및 트리플루오로메틸로 부터 선택된 하나 또는 두개의 치환분에 의해 치환되었거나 비치환 되었다); 또는, (ii)는 Y는 A는 함께 5또는 6개의 환탄소를 함유하는 1-하이드록시사이클로 알킬라디칼을 형성하며 이것은 임의로 벤젠환에 결합되어 있으며, 상기한 알킬라디칼 및 알킬부분의 직쇄 또는 분지쇄로서 각기 1-4개의 탄소원자를 함유하며, 생성물은 어떤 기하학적 또는 광학적이성채나 그의 혼합물 형태로 있을 수 있다, (1) Y가 상기 구조식(Ⅱ)의 라디칼을 나타내며(여기서 R6는 상기 정의한 바와 같으며 R7은 수소를 나타낸다)A,R,R1,및 R2가 R1및/또는 R2가 수소가 아닌 경우를 제외하곤 상기 정의한 바와같으며 생성물이 Z 배위를 갖는 경우, 하기 구조식(Ⅲ)의 화합물을 하기 구조식(Ⅳ)의 카르보음이온과 반응시키고; 또는,A-CO-R6(Ⅲ)(Ⅳ)상기 식들에서, A와 R6는 상기한 바와같으며 나머지 부호들은 R1및/또는 R2가 수소가 아닌것을 제외하곤 상기 정의한 바와 같다. (2) Y가 상기 구조식(Ⅱ)의 라디칼을 나타내며(여기서 R6와 R7은 수소를 나타낸다), A가 상기 (i)에서 정의한 바와같으며, R1이 수소를 나타내며, R2가 수소 또는 C2-4알케닐에 의해 치환되었거나 비치환된 알킬을 나타내며, R3가 상기 정의한 바와 같으며, R4및 R5가 수소를 나타내며, 생성물이 Z 배위를 갖는 경우, 하기 구조식(XIV)의 디하이드로푸란 환을 계환하고; 또는(ⅩⅣ)상기 식에서, A는 상기 (i)에서 정의한 바와 같으며 R2′는 C2-4알케닐에 의해 치환되거나 비치환된 알킬을 나타낸다.(3) Y가 유황을 나타내고 R4와 R5가 수소를 나타내며, A가 상기 (i)에서 정의한 바와 같고 나머지 부호들이 R1및/또는 R2가 수소가 아닌것을 제외하곤 상기 정의한 바와 같으며, 생성물이 Z 또는 E 배위를 갖는 경우, 하기 구조식(XⅦ)의 메르캅탄을 하기 구조식(XⅧ)의 화합물과 반응시킨 다음 얻어진 구조식(XⅨ)의 중간체를 환원시키고; 또는A-SH (XⅦ)(XⅧ)(XⅨ)상기 식들에서 A는 상기 (i)에서 정의한 바와같으며, R,R1,R2및 R3는 R|1및/또는 R2가 수소가 아닌 경우를 제외하곤 상기 정의한 바와 같으며, Hal은 할로겐을 나타내며 X′는 음이온을 나타낸다. (4) Y가 유황을 나타내며, R4및 R5가 수소를 나타내며, A가 상기 (i)에서 정의한 바와 같으며, 나머지 부호들이 상기 정의한 바와 같으며 생성물이 E 또는 Z배위를 갖는 경우, 암모니아 또는 하기 구조식(XX)의 아민을 하기 구조식(XXI)의 알데히드와 반응시키거나;(XX)(XXI)상기 식들에서, R1,및 R2는 상기 정의한 바와 같으며, A는 상기 (i)에서 정의한 바와 같으며, R 및 R3는 상기 정의한 바와 같으며 이것은 E 또는 Z배위를 갖는다; (5) Y가 구조식(Ⅱ)의 라디칼을 나타내거나(여기서 R7은 수소를 나타냄)또는 Y가 상기 (ii)에서 정의한 바와 같으며 나머지 부호들이 상기 정의한 바와같은 경우 하기 구조식(XXⅢ)의 유기마그네슘 유도체를 하기 구조식(XXIV)의 화합물과 반응시키고; 또는(XXⅢ)(XXIV)상기 식들에서, R은 상기 정의한 바와 같으며, X0는 할로겐 원자를 나타내며 나머지 부호들은 상기 정의한 바와 같다. (6) Y가 구조식(Ⅱ)의 라디칼을 나타내며(여기서 R7은 알킬카보닐, 알킬옥시카보닐 또는 벤조일을 나타냄)나머지 부호들이 상기한 바와같은 경우, 하기 구조식(XXⅦ)의 화합물을 Y가 수소원자를 나타내며 나머지 부호들이 상기 정의한 바와 같은 구조식(Ⅰ)의 화합물, 즉 하기 구조식(XXⅧ)의 화합물과 반응시키고; 또는,R7'X1(XXⅦ)(XXⅧ)상기 식들에서 R7′은 알킬카보닐, 알킬옥시카보닐 또는 벤조일을 나타내며, X1은 반응성 에스테르 잔기를 나타낸다. (7) Y가 유황 또는 구조식(Ⅱ)의 라디칼(상기 정의한 바와 같음)을 나타내며 R4및 R5가 수소를 나타내며 나머지 부호들이 상기 정의한 바와 같으며, 생성물이 E 또는 Z배위를 갖는 경우, 암모니아, 아민전구체 또는 하기 구조식(XX)의 아민을 하기 구조식(XXIX)의 화합물과 반응시킨 다음, Y가 R7가 수소인 구조식(Ⅱ)의 라디칼을 나타내며 R4및 R5가 수소를 나타내며 나머지 부호들이 상기한 바와 같은 구조식(Ⅰ)의 화합물을 얻기 위해서 얻어진 생성물을 임의로 가수분해시키고; 또는,(XX)(XXIX)상기 식들에서, A는 상기 (i)에서 정의한 바와 같으며 R은 상기 정의한 바와 같으며 (a)-X는 염소를 나태내고 Y′는 유황 또는 구조식(Ⅱ)의 라디칼(여기서 R6는 상기 정의한 바와 같으며, R7은 알킬옥시카보닐을 나타낸다)을 나타내며 E 또는 Z 배위를 갖는다. (8) Y가 구조식(Ⅱ)의 라디칼을 나타내며 (여기서 R7은 알킬아미노카보닐을 나타낸다), 나머지 부호들이 상기 정의한 바와같은 경우 하기 구조식(XXX)의 이소시아네이트를 Y가 구조식(Ⅱ)의 라디칼을 나타내며(R7은 수소를 나타냄), 나머지 부호들이 상기 정의한 바와같은 일반식(Ⅰ)의 화합물, 즉 하기 구조식(XXⅧ)의 화합물과 반응시키고; 또는,O=C=-N-R˝7(XXX)(XXⅧ)상기 식들에서, R7″은 일킬을 나타낸다, (9) Y가 설피닐 또는 설포닐을 나타내며, 나머지 부호들이 상기 정의한 바와같은 경우, Y가 유황을 나타내며 나머지 부호들이 상기 정의한 바와같은 구조식(Ⅰ)의 화합물 즉 하기 구조식(XXXI)의 화합물을 산화시키고;(XXXI)얻어진 생성물을 단리시킨 다음 임의로 이것을 제약상 허용되는 염으로 전환시킨다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8402338 | 1984-02-16 | ||
| FR8402338A FR2559765B1 (fr) | 1984-02-16 | 1984-02-16 | Nouveaux derives de la phenyl-3 propene-2 amine, leur preparation et les medicaments qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR850006934A true KR850006934A (ko) | 1985-10-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850000935A KR850006934A (ko) | 1984-02-16 | 1985-02-15 | 3-페닐-2-프로펜아민 유도체의 제법 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US4686309A (ko) |
| EP (1) | EP0153890B1 (ko) |
| JP (1) | JPS60208948A (ko) |
| KR (1) | KR850006934A (ko) |
| AT (1) | ATE39682T1 (ko) |
| AU (1) | AU576347B2 (ko) |
| CA (1) | CA1250298A (ko) |
| CS (1) | CS252826B2 (ko) |
| DD (6) | DD243277A5 (ko) |
| DE (1) | DE3567201D1 (ko) |
| DK (1) | DK74185A (ko) |
| ES (6) | ES8602605A1 (ko) |
| FR (1) | FR2559765B1 (ko) |
| GR (1) | GR850388B (ko) |
| HU (1) | HUT41714A (ko) |
| IL (1) | IL74324A (ko) |
| MA (1) | MA20349A1 (ko) |
| PT (1) | PT79975B (ko) |
| SU (2) | SU1402251A3 (ko) |
| ZA (1) | ZA851127B (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826844A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
| US4745191A (en) * | 1987-09-30 | 1988-05-17 | American Home Products Corporation | 1-((A-substituted phenyl-ω-substituted piperazinyl)alkenyl) cyclohexanol |
| US4996235A (en) * | 1987-11-25 | 1991-02-26 | Eli Lilly And Company | 3,4-diphenylbutanamines |
| US4902710A (en) * | 1988-12-14 | 1990-02-20 | Eli Lilly And Company | Serotonin and norepinephrine uptake inhibitors |
| DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| DE10048714A1 (de) * | 2000-09-30 | 2002-04-11 | Gruenenthal Gmbh | 5-Amino-1-penlen-3-ol-Derivate |
| US20050176136A1 (en) * | 2003-11-19 | 2005-08-11 | Dexcom, Inc. | Afinity domain for analyte sensor |
| CN103819400B (zh) * | 2013-09-16 | 2016-05-04 | 江西师范大学 | 一种多组分反应合成具有不对称结构1.4-二氢吡啶及其衍生物的方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3978129A (en) * | 1972-01-28 | 1976-08-31 | A. H. Robins Company, Incorporated | Alkenyl- and alkanylamines |
| US4056630A (en) * | 1973-02-24 | 1977-11-01 | Beecham Group Limited | Diphenylpropylamines for treating depression |
| US4018895A (en) * | 1974-01-10 | 1977-04-19 | Eli Lilly And Company | Aryloxyphenylpropylamines in treating depression |
| US4018845A (en) * | 1975-06-06 | 1977-04-19 | Uop Inc. | Hydrocarbon isomerization process |
| JPS5896045A (ja) * | 1981-11-30 | 1983-06-07 | Sumitomo Chem Co Ltd | 新規なジフエニルアルカノアミン誘導体およびその製造法 |
-
1984
- 1984-02-16 FR FR8402338A patent/FR2559765B1/fr not_active Expired
-
1985
- 1985-02-08 MA MA20573A patent/MA20349A1/fr unknown
- 1985-02-12 IL IL74324A patent/IL74324A/xx unknown
- 1985-02-13 GR GR850388A patent/GR850388B/el unknown
- 1985-02-14 AT AT85400254T patent/ATE39682T1/de active
- 1985-02-14 EP EP85400254A patent/EP0153890B1/fr not_active Expired
- 1985-02-14 AU AU38726/85A patent/AU576347B2/en not_active Ceased
- 1985-02-14 DE DE8585400254T patent/DE3567201D1/de not_active Expired
- 1985-02-14 ZA ZA851127A patent/ZA851127B/xx unknown
- 1985-02-15 DD DD85287313A patent/DD243277A5/de unknown
- 1985-02-15 ES ES540471A patent/ES8602605A1/es not_active Expired
- 1985-02-15 US US06/702,088 patent/US4686309A/en not_active Expired - Fee Related
- 1985-02-15 DK DK74185A patent/DK74185A/da not_active Application Discontinuation
- 1985-02-15 HU HU85576A patent/HUT41714A/hu unknown
- 1985-02-15 DD DD85287060A patent/DD243022A5/de unknown
- 1985-02-15 PT PT79975A patent/PT79975B/pt unknown
- 1985-02-15 CA CA000474436A patent/CA1250298A/fr not_active Expired
- 1985-02-15 JP JP60028164A patent/JPS60208948A/ja active Pending
- 1985-02-15 DD DD85287135A patent/DD243024A5/de unknown
- 1985-02-15 DD DD85273319A patent/DD239403A5/de unknown
- 1985-02-15 DD DD85287682A patent/DD243491A5/de unknown
- 1985-02-15 CS CS851089A patent/CS252826B2/cs unknown
- 1985-02-15 KR KR1019850000935A patent/KR850006934A/ko not_active Application Discontinuation
- 1985-07-17 ES ES545314A patent/ES8604519A1/es not_active Expired
- 1985-07-17 ES ES545310A patent/ES8700224A1/es not_active Expired
- 1985-07-17 ES ES545311A patent/ES8604484A1/es not_active Expired
- 1985-07-17 ES ES545313A patent/ES8604486A1/es not_active Expired
- 1985-07-17 ES ES545312A patent/ES8604485A1/es not_active Expired
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1986
- 1986-01-14 DD DD86287435A patent/DD243494A5/de unknown
- 1986-03-14 SU SU864027084A patent/SU1402251A3/ru active
- 1986-03-14 SU SU864027077A patent/SU1391495A3/ru active
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1987
- 1987-02-03 US US07/010,558 patent/US4755599A/en not_active Expired - Fee Related
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