KR840004089A - 구아니디노 헤테로사이클릭페닐아미딘의 제조방법 - Google Patents
구아니디노 헤테로사이클릭페닐아미딘의 제조방법Info
- Publication number
- KR840004089A KR840004089A KR1019830001151A KR830001151A KR840004089A KR 840004089 A KR840004089 A KR 840004089A KR 1019830001151 A KR1019830001151 A KR 1019830001151A KR 830001151 A KR830001151 A KR 830001151A KR 840004089 A KR840004089 A KR 840004089A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- formula
- compound
- reaction
- carried out
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 9
- 125000000623 heterocyclic group Chemical group 0.000 title claims 4
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 title 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000002015 acyclic group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- -1 cyano, acetyl Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- IYWCBYFJFZCCGV-UHFFFAOYSA-N formamide;hydrate Chemical compound O.NC=O IYWCBYFJFZCCGV-UHFFFAOYSA-N 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/535—Organo-phosphoranes
- C07F9/5355—Phosphoranes containing the structure P=N-
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5463—Compounds of the type "quasi-phosphonium", e.g. (C)a-P-(Y)b wherein a+b=4, b>=1 and Y=heteroatom, generally N or O
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Cosmetics (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시킴을 특징으로 하여 일반식(Ⅰ)의 화합물 및 그의 토오토머 및 산부가염을 제조하는 방법.상기 일반식에서R, R1및 R2는 같거나 다르며, 각각 수소원자 또는 탄소수 1내지 4의 알킬그룹을 나타내며, R3는 산소, 유황, 또는 질소원자 등의 헤테로원자를 임의로 함유하는 직쇄 또는 측쇄 알킬그룹, 직쇄 또는 측쇄알킬닐 그룹, 알키닐그룹, 시아노그룹, 사이클로알킬 또는 지환족 알킬 그룹, 비사이클릭그룹, 아릴그룹, 헤테로사이클릭그룹을 나타내거나 R3및 R2는 이들이 부착된 질소원자와 함께 헤테로사이클릭그룹을 나타내며, R4는 수소원자, 탄소수 1 내지 4의 알킬 또는 알콕시 그룹 또는 할로겐원자를 나타내며, Het는 두개 또는 세개의 헤테로원자를 함유하는 치환되거나 비치환된 헤테로사이클릭 그룹을 나타내며 A는 메톡시 또는 에톡시 그룹을 나타낸다.
- 제1항에 있어서 불활성 유기용매 존재하에 반응을 수행하는 방법.
- 제2항에 있어서 불활성 유기용매가 에탄올, 디옥산 또는 아세톤인 방법.
- 제1 내지 3항의 어느 하나에 있어 반응을 20 내지 60℃에서 수행하는 방법.
- 일반식(Ⅵ)의 화합물을 상기 일반식(Ⅱ)의 아민과 반응시킴을 특징으로 하여 상기 일반식(Ⅰ)의 화합물을 제조하는 방법.상기 일반식에서 R2및 R3는 제1항에서 전술한 바와 같고 Y는 메틸 또는 에틸 그룹을 나타낸다.
- 제5항에 있어서 반응을 20 내지 80℃에서 수행하는 방법.
- 일반식(Ⅶa) 또는 (Ⅶb) 화합물을 일반식(Ⅳ)의 아민과 반응시킴을 특징으로 하여 상기 일반식(Ⅰ) 화합물을 제조하는 방법.상기 일반식에서 R, R1내지 R4및 Het는 제1항에서 전술한 바와 같고, B는 시아노, 아세틸, 카브에톡시 또는 카바밀 그룹을 나타낸다.
- 제7항에 있어서 물 또는 디메틸포름아미드 존재하에 반응을 수행하는 방법.
- 제7 및 8항에 있어서 반응을 실온에서 수행하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20356A/82 | 1982-03-24 | ||
| IT20356/82A IT1200371B (it) | 1982-03-24 | 1982-03-24 | Guanidino eterociclifenilamidine,processi per la loro preparazione e loro impiego farmaceutico |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840004089A true KR840004089A (ko) | 1984-10-08 |
Family
ID=11165991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830001151A KR840004089A (ko) | 1982-03-24 | 1983-03-22 | 구아니디노 헤테로사이클릭페닐아미딘의 제조방법 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US4548944A (ko) |
| EP (1) | EP0089730B1 (ko) |
| JP (1) | JPS58185574A (ko) |
| KR (1) | KR840004089A (ko) |
| AT (1) | ATE27455T1 (ko) |
| AU (1) | AU562246B2 (ko) |
| CA (1) | CA1190546A (ko) |
| DD (1) | DD232704A5 (ko) |
| DE (2) | DE89730T1 (ko) |
| DK (1) | DK63183A (ko) |
| ES (3) | ES8404982A1 (ko) |
| FI (1) | FI78476C (ko) |
| GB (1) | GB2116975B (ko) |
| GR (1) | GR77435B (ko) |
| HU (1) | HU187877B (ko) |
| IL (1) | IL68204A (ko) |
| IT (1) | IT1200371B (ko) |
| NO (1) | NO159269C (ko) |
| NZ (1) | NZ203663A (ko) |
| PL (2) | PL138921B1 (ko) |
| PT (1) | PT76432B (ko) |
| SU (2) | SU1151208A3 (ko) |
| YU (2) | YU43160B (ko) |
| ZA (1) | ZA832016B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1210914B (it) * | 1982-07-29 | 1989-09-29 | Angeli Inst Spa | Eterociclilfenilsolfonil e fosfonilamidine sostituite, procedimento per la loro preparazione e loro uso farmaceutico. |
| GB9125970D0 (en) * | 1991-12-06 | 1992-02-05 | Fujisawa Pharmaceutical Co | New compounds |
| GB9211163D0 (en) * | 1992-05-26 | 1992-07-08 | Fujisawa Pharmaceutical Co | New oxazole derivatives |
| US6787490B2 (en) * | 2001-12-26 | 2004-09-07 | Kimberly-Clark Worldwide, Inc. | Glove donning delivery system |
| KR100969686B1 (ko) | 2006-08-07 | 2010-07-14 | 한국과학기술연구원 | 신규한 티아졸계 화합물 및 이를 함유하는 ｔ-형 칼슘 채널저해제 |
| WO2022034121A1 (en) | 2020-08-11 | 2022-02-17 | Université De Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54132566A (en) * | 1978-01-18 | 1979-10-15 | Ici Ltd | Guanidine derivative*its manufacture and secretion controlling pharmaceutical composition containing it |
| EP0014057B1 (en) * | 1979-01-18 | 1985-01-02 | Imperial Chemical Industries Plc | Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| IT1209431B (it) * | 1980-11-28 | 1989-07-16 | Angeli Inst Spa | Imidazolilfenil amidine, processi per la loro preparazione e loro impiego farmaceutico, ed intermedi di preparazione. |
-
1982
- 1982-03-24 IT IT20356/82A patent/IT1200371B/it active
-
1983
- 1983-02-10 US US06/465,572 patent/US4548944A/en not_active Expired - Fee Related
- 1983-02-14 DK DK63183A patent/DK63183A/da not_active Application Discontinuation
- 1983-03-22 KR KR1019830001151A patent/KR840004089A/ko not_active Application Discontinuation
- 1983-03-22 DD DD83249053A patent/DD232704A5/de not_active IP Right Cessation
- 1983-03-22 FI FI830940A patent/FI78476C/fi not_active IP Right Cessation
- 1983-03-22 EP EP83200388A patent/EP0089730B1/en not_active Expired
- 1983-03-22 YU YU689/83A patent/YU43160B/xx unknown
- 1983-03-22 AT AT83200388T patent/ATE27455T1/de not_active IP Right Cessation
- 1983-03-22 DE DE198383200388T patent/DE89730T1/de active Pending
- 1983-03-22 DE DE8383200388T patent/DE3371784D1/de not_active Expired
- 1983-03-23 NO NO831027A patent/NO159269C/no unknown
- 1983-03-23 ES ES520869A patent/ES8404982A1/es not_active Expired
- 1983-03-23 SU SU833566497A patent/SU1151208A3/ru active
- 1983-03-23 PL PL1983241145A patent/PL138921B1/pl unknown
- 1983-03-23 PT PT76432A patent/PT76432B/pt unknown
- 1983-03-23 HU HU83976A patent/HU187877B/hu not_active IP Right Cessation
- 1983-03-23 IL IL68204A patent/IL68204A/xx unknown
- 1983-03-23 CA CA000424307A patent/CA1190546A/en not_active Expired
- 1983-03-23 JP JP58048611A patent/JPS58185574A/ja active Pending
- 1983-03-23 GR GR70860A patent/GR77435B/el unknown
- 1983-03-23 AU AU12732/83A patent/AU562246B2/en not_active Ceased
- 1983-03-23 PL PL1983246384A patent/PL139031B1/pl unknown
- 1983-03-23 NZ NZ203663A patent/NZ203663A/en unknown
- 1983-03-23 ZA ZA832016A patent/ZA832016B/xx unknown
- 1983-03-23 GB GB08307957A patent/GB2116975B/en not_active Expired
- 1983-03-23 ES ES520867A patent/ES8404980A1/es not_active Expired
- 1983-03-23 ES ES520868A patent/ES8404981A1/es not_active Expired
- 1983-12-05 SU SU833675010A patent/SU1251804A3/ru active
-
1985
- 1985-06-24 US US06/748,309 patent/US4645841A/en not_active Expired - Fee Related
- 1985-09-24 YU YU1521/85A patent/YU43418B/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR870003998A (ko) | 퀴나졸린 유도체류의 제조방법 | |
| KR830007642A (ko) | 7-아미노-1-사이클로프로필-4-옥소-1,4-디하이드로-나프티리딘-3-카복실산의 제조방법 | |
| KR860000272A (ko) | 헤테로아릴옥시아세트아미드의 제조방법 | |
| KR840003618A (ko) | 2-시아노벤즈 이미다졸 유도체의 제조방법 | |
| KR900009593A (ko) | 2-클로로피리딘 3-카르복실산 에스테르 제조 방법 | |
| KR830007575A (ko) | 이미다졸릴페닐 아미딘 유도체의 제조방법 | |
| KR850001184A (ko) | 1,5-벤조티아제핀 유도체의 제조방법 | |
| KR840002825A (ko) | 아미노설포닐 우레아 유도체의 제조방법 | |
| KR860000243A (ko) | 아민유도체의 제조방법 | |
| KR890011904A (ko) | 안드로스타-1,4, -디엔-3,17-디온의 6-메틸렌 유도체 합성방법 | |
| KR850008165A (ko) | 헤테로사이클릭 유도체의 제조방법 | |
| KR840004089A (ko) | 구아니디노 헤테로사이클릭페닐아미딘의 제조방법 | |
| KR840008023A (ko) | 크로몬-및 티오크로몬-치환된 1,4- 디하이드로피리딘유도체의 제조방법 | |
| KR840001177A (ko) | 제초제인 설폰아미드의 제조방법 | |
| KR830004301A (ko) | 3,6,7,8-치환-s-트리아졸로[4,3-b] 피리다진 및 이의 조성물 | |
| KR850001907A (ko) | 구충제 화화물 및 조성물의 제조방법 | |
| KR850006934A (ko) | 3-페닐-2-프로펜아민 유도체의 제법 | |
| KR850001173A (ko) | 2-치환된 4-페닐이미다졸 아미딘 유도체의 제조방법 | |
| KR860003231A (ko) | 2-시아노벤즈 이미다졸 유도체의 제조방법 | |
| KR840006226A (ko) | 티아트리아진 유도체의 제조방법 | |
| KR830002744A (ko) | 구아니딘 화합물의 제조방법 | |
| KR860000295A (ko) | 옥시캄 유도체의 제조방법 | |
| KR840008647A (ko) | 대칭 1,4-디하이드로피리딘디카복실 에스테르의 제조방법 | |
| KR830010057A (ko) | Nn-(아릴티오알킬)-n'-(아미노알킬) 우레아의 제조방법 | |
| KR860008148A (ko) | 헤테로 사이클릭 아미드 유도체의 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |