KR830004301A - 3,6,7,8-치환-s-트리아졸로[4,3-b] 피리다진 및 이의 조성물 - Google Patents
3,6,7,8-치환-s-트리아졸로[4,3-b] 피리다진 및 이의 조성물 Download PDFInfo
- Publication number
- KR830004301A KR830004301A KR1019800004120A KR800004120A KR830004301A KR 830004301 A KR830004301 A KR 830004301A KR 1019800004120 A KR1019800004120 A KR 1019800004120A KR 800004120 A KR800004120 A KR 800004120A KR 830004301 A KR830004301 A KR 830004301A
- Authority
- KR
- South Korea
- Prior art keywords
- substituted
- amine
- formula
- lower alkyl
- pyridazine
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- -1 R 6 amine Chemical class 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 150000001412 amines Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000012433 hydrogen halide Substances 0.000 claims 1
- 229910000039 hydrogen halide Inorganic materials 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 150000003222 pyridines Chemical class 0.000 claims 1
- 239000012429 reaction media Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 다음 구조식(Ⅴ)의 3,6-디할로-4,5-치환 피리딘을 하기에서 정의된 R6에 상응하는 아민과 불용성 용매중에서 과량의 비친핵성 아민 또는 무기염기 할로겐화수소 수용체 존재하에 반응시켜 형성된 3-할로피리다진을 다음 구조식(Ⅶ)의 화합물과 불활성 액체 매질중에서 50 내지 200℃로 반응시키거나 다음 구조식(Ⅲ)의 화합물을 다음 구조식(Ⅳ)의 화합물과 40 내지 150℃에서 반응시킨 후 생성된 6-할로-트리아졸로 피리다진을 하기에서 정의된 R6에 상응하는 아민과 75 내지 160℃에서 반응매질로서 불활성용매 또는 과량의 R6아민 중에서 또는 R6아민과 무기염기 또는 비친핵성 아민 존재하에 반응시킴을 특징으로하여 다음 구조식(I)의 3,6,7,8-치환-s-트리아졸로[4,3-b] 피리다진을 제조하는 방법.상기 구조식에서R3는 수소 또는 저급알킬이고R6는 아미노, 저급알킬아미노, 디저급알킬아미노 또는 저급알킬 치환 헤테로사이클 아미노인데 여기에서 헤테로사이클 부위는 하나 또는 두개의 환형성 질소원자를 함유하고 또 하나의 환형성 황 또는 산소원자를 함유하거나 함유하지 않은 5 또는 7원 환을 형성하며R7은 저급알킬이고R8은 수소 또는 저급알킬이고R7및 R8은 함께 3 또는 4 메틸렌 단위를 가진 폴리메틸렌 또는 저급알킬 또는 메탄오 또는 에탄오 가교에 의해 치환된 3 또는 4 메틸렌 단위를 가진 치환 폴리메틸렌이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8907179A | 1979-10-29 | 1979-10-29 | |
| US89071 | 1979-10-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830004301A true KR830004301A (ko) | 1983-07-09 |
| KR850001701B1 KR850001701B1 (ko) | 1985-11-26 |
Family
ID=22215530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019800004120A KR850001701B1 (ko) | 1979-10-29 | 1980-10-28 | 3,6,7,8-치환된-s-트리아졸로 [4,3-b] 피리다진의 제조방법 |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0029130B1 (ko) |
| JP (1) | JPS5679690A (ko) |
| KR (1) | KR850001701B1 (ko) |
| AR (2) | AR227651A1 (ko) |
| AT (1) | ATE16808T1 (ko) |
| AU (1) | AU536351B2 (ko) |
| CA (1) | CA1144544A (ko) |
| DE (1) | DE3071278D1 (ko) |
| DK (1) | DK158353C (ko) |
| ES (2) | ES8202555A1 (ko) |
| FI (1) | FI70413C (ko) |
| GB (1) | GB2061275B (ko) |
| GR (1) | GR70309B (ko) |
| IL (1) | IL61316A (ko) |
| NO (1) | NO156011C (ko) |
| NZ (1) | NZ195355A (ko) |
| PT (1) | PT71952B (ko) |
| ZA (1) | ZA806523B (ko) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI81350C (fi) * | 1982-01-18 | 1990-10-10 | Lepetit Spa | Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat. |
| US4485106A (en) * | 1982-07-12 | 1984-11-27 | The Dow Chemical Company | Substituted tetrahydrotetrazolo[5,1-a]phthalazines |
| US4487930A (en) * | 1982-09-07 | 1984-12-11 | The Dow Chemical Company | 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines |
| IT1194310B (it) * | 1983-07-12 | 1988-09-14 | Lepetit Spa | Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti |
| US4578464A (en) * | 1983-11-22 | 1986-03-25 | Merrell Dow Pharmaceuticals Inc. | 6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds |
| US5011835A (en) * | 1990-02-07 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Substituted triazolopyridazines, pharmaceutical compositions and use |
| SG182297A1 (en) | 2009-12-31 | 2012-08-30 | Ct Nac Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| WO2013005041A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Tricyclic heterocyclic compounds as kinase inhibitors |
| WO2013005057A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncológicas (Cnio) | New compounds |
| WO2013004984A1 (en) | 2011-07-07 | 2013-01-10 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Tricyclic compounds for use as kinase inhibitors |
| CN103694244B (zh) * | 2014-01-09 | 2016-03-30 | 郑州大学 | 3,6位取代-1,2,4-三氮唑并[3,4-a]酞嗪类化合物及其制备和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3708484A (en) * | 1970-10-16 | 1973-01-02 | Sandoz Ag | Amino and substituted amino-s-triazolo-(4,3-b)-pyridazines |
| US3915968A (en) * | 1973-09-21 | 1975-10-28 | Lepetit Spa | Triazolopyridazines |
| DE2418435A1 (de) * | 1974-04-17 | 1975-10-30 | Boehringer Mannheim Gmbh | Nitroimidazolyl-triazolo-pyridazine und verfahren zu ihrer herstellung |
| US4136182A (en) * | 1976-05-26 | 1979-01-23 | The Dow Chemical Company | Triazolopyridazines used to alleviate bronchial spasms |
| CA1080712A (en) * | 1976-09-22 | 1980-07-01 | Jay D. Albright | Hypotensive agents |
-
1980
- 1980-10-11 GR GR63143A patent/GR70309B/el unknown
- 1980-10-20 IL IL61316A patent/IL61316A/xx unknown
- 1980-10-21 GB GB8033959A patent/GB2061275B/en not_active Expired
- 1980-10-21 AU AU63561/80A patent/AU536351B2/en not_active Ceased
- 1980-10-22 PT PT71952A patent/PT71952B/pt not_active IP Right Cessation
- 1980-10-23 ZA ZA00806523A patent/ZA806523B/xx unknown
- 1980-10-23 DE DE8080106450T patent/DE3071278D1/de not_active Expired
- 1980-10-23 NZ NZ195355A patent/NZ195355A/en unknown
- 1980-10-23 EP EP80106450A patent/EP0029130B1/en not_active Expired
- 1980-10-23 AT AT80106450T patent/ATE16808T1/de not_active IP Right Cessation
- 1980-10-27 FI FI803355A patent/FI70413C/fi not_active IP Right Cessation
- 1980-10-28 NO NO803218A patent/NO156011C/no unknown
- 1980-10-28 KR KR1019800004120A patent/KR850001701B1/ko active
- 1980-10-28 CA CA000363395A patent/CA1144544A/en not_active Expired
- 1980-10-28 ES ES496354A patent/ES8202555A1/es not_active Expired
- 1980-10-29 JP JP15199480A patent/JPS5679690A/ja active Granted
- 1980-10-29 DK DK457480A patent/DK158353C/da not_active IP Right Cessation
- 1980-10-30 AR AR283078A patent/AR227651A1/es active
-
1981
- 1981-11-06 ES ES506946A patent/ES8207178A1/es not_active Expired
-
1982
- 1982-02-12 AR AR288415A patent/AR227087A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0248558B2 (ko) | 1990-10-25 |
| NZ195355A (en) | 1984-09-28 |
| DE3071278D1 (en) | 1986-01-16 |
| ES496354A0 (es) | 1982-02-01 |
| DK158353B (da) | 1990-05-07 |
| ES506946A0 (es) | 1982-09-01 |
| AU6356180A (en) | 1981-05-07 |
| GB2061275A (en) | 1981-05-13 |
| ES8207178A1 (es) | 1982-09-01 |
| EP0029130B1 (en) | 1985-12-04 |
| JPS5679690A (en) | 1981-06-30 |
| ZA806523B (en) | 1982-05-26 |
| IL61316A0 (en) | 1980-12-31 |
| GB2061275B (en) | 1983-08-10 |
| EP0029130A1 (en) | 1981-05-27 |
| ES8202555A1 (es) | 1982-02-01 |
| AU536351B2 (en) | 1984-05-03 |
| AR227651A1 (es) | 1982-11-30 |
| CA1144544A (en) | 1983-04-12 |
| AR227087A1 (es) | 1982-09-15 |
| GR70309B (ko) | 1982-09-08 |
| DK457480A (da) | 1981-04-30 |
| FI70413B (fi) | 1986-03-27 |
| ATE16808T1 (de) | 1985-12-15 |
| PT71952B (en) | 1982-03-31 |
| NO803218L (no) | 1981-04-30 |
| FI803355L (fi) | 1981-04-30 |
| PT71952A (en) | 1980-11-01 |
| IL61316A (en) | 1984-03-30 |
| KR850001701B1 (ko) | 1985-11-26 |
| FI70413C (fi) | 1986-09-19 |
| NO156011C (no) | 1987-07-08 |
| DK158353C (da) | 1990-10-01 |
| NO156011B (no) | 1987-03-30 |
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