KR860008123A - 신규 디아민 유도체의 제조방법 - Google Patents

신규 디아민 유도체의 제조방법 Download PDF

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Publication number
KR860008123A
KR860008123A KR1019860002508A KR860002508A KR860008123A KR 860008123 A KR860008123 A KR 860008123A KR 1019860002508 A KR1019860002508 A KR 1019860002508A KR 860002508 A KR860002508 A KR 860002508A KR 860008123 A KR860008123 A KR 860008123A
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KR
South Korea
Prior art keywords
sub
same
carbon atoms
different
diamine derivative
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KR1019860002508A
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English (en)
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KR940005917B1 (ko
Inventor
미찌로 다까기
야스유끼 가또오
다모쓰 야마자끼
Original Assignee
쥬우가이 세이야꾸 가부시끼가이샤
우에노 기미오
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Publication of KR860008123A publication Critical patent/KR860008123A/ko
Application granted granted Critical
Publication of KR940005917B1 publication Critical patent/KR940005917B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

신규 디아민 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(Ⅱ)의 클로로알킬아닐리드 유도체를 하기 일반식(Ⅲ)의 디아민 유도체와 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 신규 디아민 유도체의 제조방법.
    (식중, R1및R2는 서로 동일하거나 다른 탄소수 1∼3의 알킬기이고, R3는 수소원자 또는 탄소수 1∼3의 알킬기이며, R4및 R5는 서로 동일하거나 다른 수소원자 또는 탄소수 1∼8의 알킬기이고, 및 m,n은 동일하거나 다른 1∼7의 정수이다. 단, R4및 R5는 동시에 수소원자일 수는 없다).
  2. 제1항에 있어서, 반응이 염기의 존재하 및 불활성용매내에서, 환류온도에서 실시됨을 특징으로 하는 제조방법.
  3. 제2항에 있어서, 불활성 용매가 벤젠, 톨루엔, 크실렌, 디클로로메탄, 클로로포름 및 에틸아세테이트 등의 군으로부터 선택되며, 염기가 트리메틸아민, 트리에틸아민, 피리딘, 탄산칼륨 및 탄산나트륨 등의 군으로부터 선택되는 제조방법.
  4. 제2항에 있어서, 반응이 20℃∼150℃의 온도에서 실시되는 제조방법.
  5. 제2항에 있어서, 반응이 트리에틸아민의 존재하 및 톨루엔내에서, 환류온도에서 실시되는 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860002508A 1985-04-02 1986-04-02 신규 디아민 유도체의 제조방법 KR940005917B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6969485 1985-04-02
JP69694 1985-04-02
JP60-69694 1985-04-02

Publications (2)

Publication Number Publication Date
KR860008123A true KR860008123A (ko) 1986-11-12
KR940005917B1 KR940005917B1 (ko) 1994-06-24

Family

ID=13410231

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860002508A KR940005917B1 (ko) 1985-04-02 1986-04-02 신규 디아민 유도체의 제조방법

Country Status (13)

Country Link
US (1) US4855497A (ko)
EP (1) EP0196648B1 (ko)
JP (1) JPS6230746A (ko)
KR (1) KR940005917B1 (ko)
CN (1) CN1021908C (ko)
AT (1) ATE40677T1 (ko)
AU (1) AU593240B2 (ko)
CA (1) CA1290347C (ko)
DE (1) DE3662039D1 (ko)
ES (1) ES8706615A1 (ko)
HU (1) HU196357B (ko)
SU (1) SU1500155A3 (ko)
ZA (1) ZA862348B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4344648A1 (de) * 1993-12-24 1995-06-29 Dresden Arzneimittel Neue Aminocarbonsäureamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5779941A (en) * 1996-04-26 1998-07-14 Tatsuta Electric Wire And Cable Co., Ltd. 1,2-N-acyl-N-methylene-ethylenediamine, and electroconductive paste comprising it
US6789014B1 (en) * 2003-05-09 2004-09-07 Deere & Company Direct modification of DGPS information with inertial measurement data

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2644003A (en) * 1950-02-24 1953-06-30 Geigy Ag J R Quaternary ammonium compounds and their manufacture
US2948736A (en) * 1957-08-05 1960-08-09 Cilag Chemie New anilides and process for their production
US3401203A (en) * 1964-01-21 1968-09-10 Sun Chemical Corp Preparation of amines
CS156707B1 (ko) * 1969-12-23 1974-08-23
GB1276968A (en) * 1970-01-15 1972-06-07 Lepetit Spa Improvements in or relating to phenylacetamides and the preparation thereof
NL7302541A (ko) * 1972-02-28 1973-08-30
JPS568527B2 (ko) * 1973-05-14 1981-02-24
US3988473A (en) * 1973-06-12 1976-10-26 Astra Pharmaceutical Products, Inc. Tertiary-alkylamino-lower acyl-xylidide local anaesthetics
GB1458898A (en) * 1974-03-18 1976-12-15 Science Union & Cie Ortho alkoxyanilides a process for their preparation and pharmaceutical compositions containing them
US4070485A (en) * 1974-03-18 1978-01-24 Science Union Et Cie Alkoxy anilides process for preparing the same and pharmaceutical compositions
GB1518107A (en) * 1975-02-14 1978-07-19 Science Union & Cie Anilides process for their preparation and pharmaceutical compositions containing them
JPS598269B2 (ja) * 1975-08-22 1984-02-23 萬有製薬株式会社 オメガ − アミノアルカンサンアリ−ルアミドノ セイホウ
US4187318A (en) * 1975-09-26 1980-02-05 Eli Lilly And Company Rodenticidal N-alkyldiphenylamines
GB1574019A (en) * 1977-01-14 1980-09-03 Joullie International Sa Therapeutically useful 3,4,5-trimethoxybenzene derivatives
DE2915250A1 (de) * 1979-04-14 1980-10-30 Basf Ag Salze von alpha -aminoacetaniliden
IT1150959B (it) * 1980-06-10 1986-12-17 Simes Sostanze datate di attivita' antispastica vasale e procedimenti per la loro preparazione
US4562201A (en) * 1982-07-26 1985-12-31 American Hospital Supply Corporation Aminomethyl benzanilides
US4536346A (en) * 1983-05-06 1985-08-20 American Cyanamid Company Aralkanamidophenyl compounds

Also Published As

Publication number Publication date
EP0196648A1 (en) 1986-10-08
JPS6230746A (ja) 1987-02-09
ES8706615A1 (es) 1987-06-16
SU1500155A3 (ru) 1989-08-07
CN86102285A (zh) 1986-11-12
AU5521086A (en) 1986-10-09
HUT40999A (en) 1987-03-30
HU196357B (en) 1988-11-28
ATE40677T1 (de) 1989-02-15
ES553600A0 (es) 1987-06-16
AU593240B2 (en) 1990-02-08
US4855497A (en) 1989-08-08
JPH0466476B2 (ko) 1992-10-23
CN1021908C (zh) 1993-08-25
ZA862348B (en) 1986-11-26
DE3662039D1 (de) 1989-03-16
CA1290347C (en) 1991-10-08
EP0196648B1 (en) 1989-02-08
KR940005917B1 (ko) 1994-06-24

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