KR830006237A - 카바모일옥시아미노-1,4-벤조디아제핀의 제조방법 - Google Patents

카바모일옥시아미노-1,4-벤조디아제핀의 제조방법 Download PDF

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KR830006237A
KR830006237A KR1019810001988A KR810001988A KR830006237A KR 830006237 A KR830006237 A KR 830006237A KR 1019810001988 A KR1019810001988 A KR 1019810001988A KR 810001988 A KR810001988 A KR 810001988A KR 830006237 A KR830006237 A KR 830006237A
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South Korea
Prior art keywords
carbon atoms
following general
general formula
formula
alkyl
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KR1019810001988A
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KR850000452B1 (ko
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푀르슈 만프레드
게르하르트 헤르만
Original Assignee
헤인리히 벡커
훽스트 아크티엔 게쩔샤프트
베른하르트 벡크
훽스트 아크티엔 게젤샤프트
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Publication of KR830006237A publication Critical patent/KR830006237A/ko
Priority to KR1019840005956A priority Critical patent/KR850000450B1/ko
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Publication of KR850000452B1 publication Critical patent/KR850000452B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

카바모일옥시아미노-1,4-벤조디아제핀의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 일반식 (Ⅱ)화합물을 다음 일반식 (Ⅲ)의 이소시아네이트 또는 다음 일반식 (Ⅳ)의 반응성 카르밤산유도체와 반응시키거나, 다음 일반식 (V)화합물을 하이드로실아민 또는 반응동안 염기로 유리되는 하이드록실아민의 염과 반응시킨 후 일반식 (Ⅲ)의 이소시아네이트 또는 일반식 (Ⅳ)의 카르밤산유도체와 반응시키거나 또는 다음 일반식 (V)화합물을 다음 일반식 (Ⅵ)의 O-아실화하이드록실아민과 반응시킴을 특징으로하여 다음 일반식(I) 및 (IA)의 카바모일옥시아미노-1,4-벤조디아제핀을 제조하는 방법.
    상기 일반식에서
    R1은 수소원자 또는 니트로 또는 트리플루오로메틸 그룹이고
    R2는 페닐, 피리딜 또는 탄소수 1내지 4의 알킬, 탄소수 1내지 4의 알콕시, 하이드록시, 할로겐 또는 트리플루오로메틸에 의해 모노 또는 이치환된 페닐환이고
    R3는 수소 또는 탄소수 1내지 4의 알킬, 모노알킬 카바모일 또는 디알킬카바모일 그룹이고
    R4는 페닐 또는 할로겐, 니트로, 시아노, 트리플루오로메틸, 탄소수 1내지 4의 알킬 또는 알콕시, 하이드록시 또는 각 알킬그룹에 1내지 4의 탄소원자가 함유된 디알킬아미노에 의해 모노 또는 디치환된 페닐환이고
    X는 할로겐 또는 페녹시이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810001988A 1980-06-04 1981-06-03 카바모일옥시아미노-1, 4-벤조디아제핀의 제조방법 KR850000452B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840005956A KR850000450B1 (ko) 1980-06-04 1984-09-27 카바모일옥시아미노-1, 4-벤조디아제핀의 제조방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803021107 DE3021107A1 (de) 1980-06-04 1980-06-04 Carbamoyloxyamino-1,4-benzodiazepine, verfahren zu irer herstellung und diese enthaltende arzneimittel
DE3021107.5 1980-06-04

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019840005956A Division KR850000450B1 (ko) 1980-06-04 1984-09-27 카바모일옥시아미노-1, 4-벤조디아제핀의 제조방법

Publications (2)

Publication Number Publication Date
KR830006237A true KR830006237A (ko) 1983-09-20
KR850000452B1 KR850000452B1 (ko) 1985-04-05

Family

ID=6103913

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019810001988A KR850000452B1 (ko) 1980-06-04 1981-06-03 카바모일옥시아미노-1, 4-벤조디아제핀의 제조방법
KR1019840005956A KR850000450B1 (ko) 1980-06-04 1984-09-27 카바모일옥시아미노-1, 4-벤조디아제핀의 제조방법

Family Applications After (1)

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KR1019840005956A KR850000450B1 (ko) 1980-06-04 1984-09-27 카바모일옥시아미노-1, 4-벤조디아제핀의 제조방법

Country Status (20)

Country Link
US (1) US4395409A (ko)
EP (1) EP0041242B1 (ko)
JP (1) JPS5724371A (ko)
KR (2) KR850000452B1 (ko)
AR (1) AR229955A1 (ko)
AT (1) ATE8392T1 (ko)
AU (1) AU540897B2 (ko)
CA (1) CA1162190A (ko)
DE (2) DE3021107A1 (ko)
DK (1) DK244781A (ko)
ES (1) ES502603A0 (ko)
FI (1) FI811705L (ko)
GR (1) GR74614B (ko)
HU (1) HU186889B (ko)
IL (1) IL63025A (ko)
NO (1) NO811882L (ko)
NZ (1) NZ197273A (ko)
PH (1) PH16605A (ko)
PT (1) PT73124B (ko)
ZA (1) ZA813695B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60156769A (ja) * 1984-01-26 1985-08-16 Daicel Chem Ind Ltd 導電性水分散塗料
US4755508A (en) * 1984-06-26 1988-07-05 Merck & Co., Inc. Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin
JPS63156837A (ja) * 1986-12-19 1988-06-29 Kanebo Ltd 防黴殺菌性を有するポリビニルアセタール系多孔質体の製造方法
US4886626A (en) * 1987-05-19 1989-12-12 Crest-Foam Corporation Conductive polyurethane foam compositions containing tetralyanoethylene and method
US5028355A (en) * 1987-05-19 1991-07-02 Crest-Foam Corporation Conductive polyurethane foam containing picric acid and analog thereof
EP3535253A1 (en) * 2016-11-01 2019-09-11 H. Hoffnabb-La Roche Ag 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of cns related diseases

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3268586A (en) * 1966-08-23 Armnophenyl cycloalkyl ketones
US3205223A (en) * 1965-09-07 Process and intermediates for preparing z-amino-j-hydroxy
CH438339A (de) * 1963-11-15 1967-06-30 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
BE759099A (fr) * 1969-11-18 1971-04-30 Takeda Chemical Industries Ltd Procede de fabrication de composes heterocycliques
US3649617A (en) * 1970-07-20 1972-03-14 Upjohn Co 2-substituted amino-5-phenyl-3h-1 4-benzodiazepines
US3799920A (en) * 1970-08-24 1974-03-26 Siphar Sa 1,4-benzodiazepine derivatives
US3857854A (en) * 1971-09-08 1974-12-31 Upjohn Co 6-phenyl-1h,4h-{8 1,2,4{9 oxadiazalo{8 4,3-2{9 {8 1,4{9 benzodiazepin-1-ones
US3896109A (en) * 1971-09-30 1975-07-22 Upjohn Co 2,3-dehydro-1h-1,4-benzodiazepines
US3825533A (en) * 1972-03-20 1974-07-23 American Home Prod N-carboxymethyl-n-substituted glycinate esters of 3-hydroxy-1,4-benzo-diazepin-2-ones
NL162379C (nl) * 1974-02-08 1984-07-16 Specta Speciaal Chemicalien In Werkwijze ter bereiding van benzodiazepinederivaten.
AU476528B2 (en) * 1975-07-11 1975-09-25 The Upjohn Company Novel benzodiazepines and their preparation
GB1538164A (en) * 1976-05-05 1979-01-10 Clin Midy Benzodiazepine derivatives
DE2952279A1 (de) * 1979-12-24 1981-06-25 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
PT73124B (de) 1982-11-16
PT73124A (de) 1981-07-01
ES8300722A1 (es) 1982-11-01
IL63025A (en) 1985-07-31
AU7129581A (en) 1981-12-10
GR74614B (ko) 1984-06-29
US4395409A (en) 1983-07-26
ES502603A0 (es) 1982-11-01
EP0041242A1 (de) 1981-12-09
IL63025A0 (en) 1981-09-13
NZ197273A (en) 1984-05-31
KR850000450B1 (ko) 1985-04-05
DK244781A (da) 1981-12-05
AU540897B2 (en) 1984-12-06
HU186889B (en) 1985-10-28
PH16605A (en) 1983-11-24
AR229955A1 (es) 1984-01-31
DE3021107A1 (de) 1981-12-17
CA1162190A (en) 1984-02-14
EP0041242B1 (de) 1984-07-11
JPS5724371A (en) 1982-02-08
ATE8392T1 (de) 1984-07-15
NO811882L (no) 1981-12-07
DE3164704D1 (en) 1984-08-16
ZA813695B (en) 1982-06-30
KR850000452B1 (ko) 1985-04-05
FI811705L (fi) 1981-12-05

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