KR880003965A - 이노소오스 유도체, 그의 제조방법 및 용도 - Google Patents

이노소오스 유도체, 그의 제조방법 및 용도 Download PDF

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KR880003965A
KR880003965A KR1019870009931A KR870009931A KR880003965A KR 880003965 A KR880003965 A KR 880003965A KR 1019870009931 A KR1019870009931 A KR 1019870009931A KR 870009931 A KR870009931 A KR 870009931A KR 880003965 A KR880003965 A KR 880003965A
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general formula
hydroxy
halogen
following general
inosose
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KR1019870009931A
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KR950006803B1 (ko
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사또시 호리이
히로시 후까세
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다께다야꾸힝고오교 가부시끼가이샤
우메모또 요시마사
다께다야꾸힝 고오교 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

이노소오스 유도체, 그의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 하기 일반식(I)의 이노소오스 화합물 :
    식중, X1및 X2는 둘다 할로겐이거나 ; X1는 수소이고 및 X2는 할로겐이거나 ; 또는 X1은 -SQ1이고 및 X2는 -SQ2(식중, Q1및 Q2는 각각 저급 알킬이거나 또는 Q1및 Q2는 저급 알킬렌을 형성한다.)이며 ; R1은 히드록시-보호기이고 ; 및 Y는 =0, =N-Z(식중 Z는 (보호) 히드록시이다.) 또는(식중, A는 수소 또는 아민잔기이다.)이다.
  2. 제1항에 있어서, 식중 Y가 =0인 이노소오스 화합물.
  3. 하기 일반식(4)로 나타내어지는 화합물을 염기로 처리함을 특징으로 하는 하기 일반식(a)로 나타내어지는 이노소오스 화합물의 제조방법.
    [식중, X1및 X2는 둘다 할로겐이거나 ; 또는 X1은 -SQ1이고 및 X2는 -SQ2(식중 Q1및 Q2는 각각 저급 알킬이거나 또는 Q1및 Q2는 저급 알킬렌을 형성한다.)이며 ; 및 R1은 히드록시-보호기이다.]
  4. 하기 일반식(5')의 화합물에 대하여 부분 탈할로겐화반응을 수행함을 특징으로 하는 하기 일반식(6')로 나타내어지는 이노소오스 화합물의 제조방법.
    식중, X1및 X2는 둘다 할로겐이고 ; 및 R1히드록시-보호기이다.)
  5. 하기 일반식(a)의 화합물을 일반식 R2-NH2(식중, R2는 아민 잔기 또는 보호 가능한 히드록시이다.)로 나타내어지는 1급 아민 또는 히드록실아민과 반응시키고, 이어서 생성물에 대하여 환원 반응 및 탈황화 반응 또는 탈할로겐화 반응을 실시한 후, 필요에 따라 탈보호 반응을 수행함을 특징으로 하는 하기 일반식(Ⅱ)로 나타내어지는 슈도아미노 슈가의 제조방법.
    [식중, X1및 X2는 둘다 할로겐이거나 ; X1는 수소이고 및 X2는 할로겐이거나 ; 또는 X1은 -SQ1이고 및 X2는 -SQ2(식중 Q1및 Q2는 각각 저급 알킬이거나 또는 Q1및 Q2는 저급 알킬렌을 형성한다.)이며 ; R1은 히드록시-보호기이고 ; R3은 수소 또는 히드록시-보호기이며 ; 및 A는 아민 잔기 또는 수소이다.]
  6. 하기 일반식(5')로 나타내어지는 화합물에 대하여 탈할로겐화 반응 또는 탈황화반응을 수행함을 특징으로 하는 하기 일반식(12)로 나타내어지는 이노소오스 화합물의 제조방법.
    [식중, X1및 X2는 둘다 할로겐이거나 ; 또는 X1-SQ1이고 및 X2는 -SQ2(식중, Q1및 Q2는 각각 저급 알킬이거나 또는 Q1및 Q2는 저급 알킬렌을 형성한다.)이며 ; R1은 히드록시-보호기이다].
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870009931A 1986-09-09 1987-09-08 이노소오스 유도체, 그의 제조방법 및 용도 KR950006803B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP21295286 1986-09-09
JP212952/1986 1986-09-09
JP212952 1986-09-09
JP26346286 1986-11-05
JP263462 1986-11-05
JP263462/1986 1986-11-05
JP779/1987 1987-01-06
JP77987 1987-01-06
JP779 1987-01-06

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KR880003965A true KR880003965A (ko) 1988-06-01
KR950006803B1 KR950006803B1 (ko) 1995-06-22

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US (2) US4898986A (ko)
EP (1) EP0260121B1 (ko)
KR (1) KR950006803B1 (ko)
CA (1) CA1293259C (ko)
DE (1) DE3784602T2 (ko)
ES (1) ES2053551T3 (ko)
HU (2) HU203317B (ko)

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AU3601899A (en) * 1998-03-31 1999-10-18 Bayer Aktiengesellschaft Valiolone, a method of preparing it, and its use to prepare acarbose and voglibose
JPWO2003080561A1 (ja) * 2002-03-27 2005-07-21 沢井製薬株式会社 ボグリボースの製造法
CN1882526A (zh) * 2003-09-26 2006-12-20 兰贝克赛实验室有限公司 制备伏格列波糖的方法
WO2005049547A1 (en) * 2003-11-21 2005-06-02 Ranbaxy Laboratories Limited Process for the preparation of 1,2,3,4-cyclohexanetetrol derivatives
WO2006032011A2 (en) * 2004-09-14 2006-03-23 Elixir Pharmaceuticals, Inc. Combination therapy for controlled carbohydrate digestion
CN101325959A (zh) * 2005-09-14 2008-12-17 伊利舍医药品公司 用于受控碳水化合物消化的联合疗法
CN101566610B (zh) * 2008-04-21 2012-07-04 重庆鼎联制药有限公司 伏格列波糖中间体的分析检测方法
US20100240883A1 (en) * 2009-03-18 2010-09-23 Nian Wu Lipid-drug conjugates for drug delivery
CN104119301B (zh) * 2013-04-27 2018-05-08 浙江海翔药业股份有限公司 一种伏格列波糖中间体及其制备方法
CN104098458B (zh) * 2014-08-07 2015-09-09 重庆植恩药业有限公司 一种伏格列波糖中间体的制备方法
CN105601485B (zh) * 2015-11-11 2017-11-07 重庆植恩药业有限公司 一种伏格列波糖中间体的制备方法
CN111748000B (zh) * 2019-03-29 2022-05-20 沈阳药科大学 3-脱氧-5-羟基-1-氨基碳糖类化合物及其用途
CN115340465B (zh) * 2022-10-20 2023-01-03 中孚药业股份有限公司 一种伏格列波糖的合成方法

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US3591643A (en) * 1968-02-28 1971-07-06 Procter & Gamble Process for the preparation of bicyclo hexane compounds and the novel compound demethyl-cis-sabinene hydrate
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US4446319A (en) * 1981-04-28 1984-05-01 Takeda Chemical Industries, Ltd. Aminocyclitols and their production

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DE3784602D1 (de) 1993-04-15
KR950006803B1 (ko) 1995-06-22
US5004838A (en) 1991-04-02
ES2053551T3 (es) 1994-08-01
HUT46029A (en) 1988-09-28
CA1293259C (en) 1991-12-17
EP0260121A3 (en) 1989-09-13
HU203317B (en) 1991-07-29
EP0260121B1 (en) 1993-03-10
DE3784602T2 (de) 1993-08-05
HU201088B (en) 1990-09-28
US4898986A (en) 1990-02-06
EP0260121A2 (en) 1988-03-16

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