KR870007907A - 디엔 유도체의 제법 - Google Patents

디엔 유도체의 제법 Download PDF

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Publication number
KR870007907A
KR870007907A KR870000884A KR870000884A KR870007907A KR 870007907 A KR870007907 A KR 870007907A KR 870000884 A KR870000884 A KR 870000884A KR 870000884 A KR870000884 A KR 870000884A KR 870007907 A KR870007907 A KR 870007907A
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KR
South Korea
Prior art keywords
producing
lower alkoxy
diene derivative
derivative according
diene
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KR870000884A
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English (en)
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KR890002428B1 (ko
Inventor
마꼬또 다까이
신 하또리
도시오 와까바야시
야스시 스와베
쇼조 미야오까
Original Assignee
도자와 미쓰오
테루모 가부시끼가이샤
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Publication of KR870007907A publication Critical patent/KR870007907A/ko
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Publication of KR890002428B1 publication Critical patent/KR890002428B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

디엔 유도체의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식(Ⅱ)로 표시되는 카르복실산의 반응성 유도체를 하기 일반식(Ⅲ)으로 표시되는 아민유도체와 반응시키고, 반응생성물인 아미도유도체를 환원시킴을 특징으로 하는 하기 일반식(Ⅰ)로 표시되는 디엔유도체의 제조방법.
    (상기 식중 R1,R2,R3및 R4는 같거나 서로 다르며, 각각 수소원자, 히드록실기 또는 저급알콕시기를 나타내고, X는 수소원자 또는 할로겐원자를 나타낸다).
  2. 제1항에 있어서, R1,R2,R3및 R4가 모두 수소원자인 디엔유도체의 제조방법.
  3. 제1항에 있어서, R1이 수소원자이고, R2,R3및 R4가 저급알콕시기인 디엔유도체의 제조방법.
  4. 제3항에 있어서, 저급알콕시기가 메톡시기인 디엔유도체의 제조방법.
  5. 제1항에 있어서, R1,R2및 R3가 저급알콕시기이고, R4가 수소원자인 디엔유도체의 제조방법.
  6. 제5항에 있어서, 저급알콕시기가 메톡시기인 디엔유도체의 제조방법.
  7. 제1항에 있어서, R1및 R3가 저급알콕시기이고, R2및 R4가 수소원자인 디엔유도체의 제조방법.
  8. 제7항에 있어서, 저급알콕시기가 메톡시기인 디엔유도체의 제조방법.
  9. 제1항에 있어서, X가 플루오르인 디엔유도체의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870000884A 1986-02-04 1987-02-04 디엔 유도체의 제법 KR890002428B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22506 1986-02-04
JP2250686 1986-02-04

Publications (2)

Publication Number Publication Date
KR870007907A true KR870007907A (ko) 1987-09-22
KR890002428B1 KR890002428B1 (ko) 1989-07-03

Family

ID=12084633

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870000884A KR890002428B1 (ko) 1986-02-04 1987-02-04 디엔 유도체의 제법

Country Status (4)

Country Link
US (1) US4792553A (ko)
EP (1) EP0232205A3 (ko)
JP (1) JPS62277370A (ko)
KR (1) KR890002428B1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0660160B2 (ja) * 1985-12-13 1994-08-10 テルモ株式会社 アミド誘導体およびこれを含有する抗アレルギ−剤
FR2614021B1 (fr) * 1987-04-14 1991-03-01 Andre Buzas Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant
FR2902427B1 (fr) * 2006-06-19 2008-08-22 Pierre Fabre Medicament Sa Derives de phenylpentadienoyle

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2139628A1 (en) * 1971-05-28 1973-01-12 Lipha 5-(4-aryl piperazino-alkyl and alkylene) indans - with tranquillizing activity
BE790971A (fr) * 1971-11-09 1973-05-07 Janssen Pharmaceutica Nv Metode ter voorkoming van patologische reakties die de funktie van het komplement vereisen
JPS4962489A (ko) * 1972-10-21 1974-06-17
CH605873A5 (en) * 1975-12-02 1978-10-13 Chemosynth Ag Antihistaminic 1-benzhydryl-4-cinnamyl-piperazine prodn.
IT1213131B (it) * 1984-02-02 1989-12-14 Yason Srl Composto ad attivita' calcio antagonista periferica, anticonvulsivante ed eumetabolica cerebrale,metodo per la sua preparazione e composizioni farmaceutiche.
JPS60222472A (ja) * 1984-03-30 1985-11-07 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
BG41728A1 (en) * 1984-12-28 1987-08-14 Ninov Crystal form of 1- benzhydryl- 4- adyl- piperazine dihydrochloride and method for its preparation
JPS61161272A (ja) * 1985-01-11 1986-07-21 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
JPS61254559A (ja) * 1985-05-07 1986-11-12 Terumo Corp ビニル誘導体およびこれを含有する５−リポキシゲナ−ゼ作用阻害剤

Also Published As

Publication number Publication date
US4792553A (en) 1988-12-20
JPH0513950B2 (ko) 1993-02-23
KR890002428B1 (ko) 1989-07-03
EP0232205A3 (en) 1989-01-25
JPS62277370A (ja) 1987-12-02
EP0232205A2 (en) 1987-08-12

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