KR870010016A - 아미드 유도체의 제조방법 - Google Patents

아미드 유도체의 제조방법 Download PDF

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Publication number
KR870010016A
KR870010016A KR870004118A KR870004118A KR870010016A KR 870010016 A KR870010016 A KR 870010016A KR 870004118 A KR870004118 A KR 870004118A KR 870004118 A KR870004118 A KR 870004118A KR 870010016 A KR870010016 A KR 870010016A
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KR
South Korea
Prior art keywords
group
general formula
alkyl group
lower alkoxy
following general
Prior art date
Application number
KR870004118A
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English (en)
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KR890003810B1 (ko
Inventor
마고또 다까이
가즈히로 오모리
다까히로 구모나까
신지 오자와
도시오 와까바야시
Original Assignee
도자와 미쓰오
데루모 가부시끼가이샤
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Priority claimed from JP61096638A external-priority patent/JPH0660160B2/ja
Application filed by 도자와 미쓰오, 데루모 가부시끼가이샤 filed Critical 도자와 미쓰오
Publication of KR870010016A publication Critical patent/KR870010016A/ko
Application granted granted Critical
Publication of KR890003810B1 publication Critical patent/KR890003810B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

아미드 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식(Ⅴ)로 나타내는 카르복시산의 반응성 유동체를 하기 일반식(Ⅵ)으로 나타내는 아민유도체와 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)로 나타내는 아미드 유도체의 제조방법.
    [상기 식들중,
    R1및 R2는 동일하거나 다르며, 각각 저급 알킬기, 벤질기, 테트라히드로푸라닐기, 저급 알콕시(저급)알킬기 또는 저급 알콕시카르보닐기를 나타내며:
    R3는 수소 원자 또는 저급 알콕시기를 나타내고:
    m은 정수 1 또는 2를 나타내며: 및
    Y는 하기 일반식(Ⅱ),(Ⅲ), 또는 (Ⅳ)의 기를 나타낸다.
    (상기식들중,
    X1및X2는 동일하거나 다르며, 각각 수소원자, 할로겐원자 또는 저급 알콕시기를 나타내며:
    n,p 및 q는 각각 정수 1-4를 나타내는 데, 단, R1및 R2가 동일하거나 다르며 각각 저급 알킬기 또는 저급 알콕시기를 나타낼때는, Y는 상기 일반식(Ⅱ)또는 (Ⅲ)의 기를 나타내지 않는다.)]
  2. 제1항에 있어서, R1이 저급 알킬기를 나타내고, R2가 벤질기, 테트라히드 로푸라닐기 또는 저급 알콕시(저급)알킬기를 나타내며, R3가 수소원자를 나타내고 Y가 일반식(Ⅳ)의 기를 나타내는 일반식(Ⅰ)로 나타내는 아미드 유도체의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870004118A 1986-04-28 1987-04-28 아미드 유도체의 제조방법 KR890003810B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP96638 1986-04-28
JP61096638A JPH0660160B2 (ja) 1985-12-13 1986-04-28 アミド誘導体およびこれを含有する抗アレルギ−剤
JP96638/1986 1986-04-28

Publications (2)

Publication Number Publication Date
KR870010016A true KR870010016A (ko) 1987-11-30
KR890003810B1 KR890003810B1 (ko) 1989-10-05

Family

ID=14170370

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870004118A KR890003810B1 (ko) 1986-04-28 1987-04-28 아미드 유도체의 제조방법

Country Status (3)

Country Link
US (1) US4859673A (ko)
EP (1) EP0244319A3 (ko)
KR (1) KR890003810B1 (ko)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB809760A (en) * 1956-04-20 1959-03-04 Lab Pharmaceutica Dr C Janssen Improvements in or relating to pharmacologically active piperazine derivatives and processes for preparing them
US4046767A (en) * 1970-09-03 1977-09-06 John Wyeth & Brother Limited Piperidino compounds
US4070484A (en) * 1973-01-18 1978-01-24 Kissei Pharmaceutical Co., Ltd. Antiallergic composition containing aromatic carboxylic amide derivatives and method of using the same
JPS59118765A (ja) * 1982-12-24 1984-07-09 Fujisawa Pharmaceut Co Ltd ピペラジン誘導体
JPS60146844A (ja) * 1984-01-09 1985-08-02 Terumo Corp ピロカテコ−ル誘導体およびこれを有効成分とする５−リポキシゲナ−ゼ作用阻害剤
JPS60214766A (ja) * 1984-04-04 1985-10-28 Terumo Corp アミド誘導体およびこれを有効成分として含有する５−リポキシゲナ−ゼ作用阻害剤
US4673684A (en) * 1984-04-04 1987-06-16 Terumo Corporation Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient
JPS6212757A (ja) * 1985-07-10 1987-01-21 Yoshitomi Pharmaceut Ind Ltd 桂皮酸アミド誘導体
JPH0660160B2 (ja) * 1985-12-13 1994-08-10 テルモ株式会社 アミド誘導体およびこれを含有する抗アレルギ−剤

Also Published As

Publication number Publication date
EP0244319A3 (en) 1990-04-25
US4859673A (en) 1989-08-22
EP0244319A2 (en) 1987-11-04
KR890003810B1 (ko) 1989-10-05

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