KR860001097A - 4-아미노-2-페닐퀴놀린의 제조방법 - Google Patents

4-아미노-2-페닐퀴놀린의 제조방법 Download PDF

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KR860001097A
KR860001097A KR1019850005110A KR850005110A KR860001097A KR 860001097 A KR860001097 A KR 860001097A KR 1019850005110 A KR1019850005110 A KR 1019850005110A KR 850005110 A KR850005110 A KR 850005110A KR 860001097 A KR860001097 A KR 860001097A
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South Korea
Prior art keywords
formula
process according
phenylquinoline
piperidinecarboxamide
quinolinyl
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KR1019850005110A
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English (en)
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프란시스 필드 죠지 (외 1)
Original Assignee
장-자크 오가이, 노베르뜨 에이·꼬똥
에프·호프만-라롯슈 앤드 캄퍼니 아크티엔 게젤샤프트
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Publication of KR860001097A publication Critical patent/KR860001097A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

내용 없음

Description

4―아미노―2―페닐퀴놀린의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 일반식(Ⅱ)의 4―할로―2―페닐퀴놀린을 일반식(Ⅲ)의 이소니페코타미드와 반응시키거나 일반식(Ⅳ)의 화합물을 일반식(Ⅴ)의 아민과 반응시킴을 특징으로 하여 일반식(Ⅰ)의 4―아미노―2―페닐퀴놀린을 제조하는 방법.
  4. NHR1R2(Ⅴ)
  5. 상기 식에서, R1및 R2는 각각 수소 또는 저급알킬이고; R3및 R4는 각각 수소, 할로겐 또는 저급알킬이나, 단, R3및 R4가 모두 수소일 수는 없고, X는 할로겐이고; Y는 할로겐, 하이드록시 또는 저급알콕시이다.
  6. 제1항에 있어서, R1및 R2가 각각 수소, 메틸 또는 에틸인 방법.
  7. 제1 또는 2항에 있어서, R3가 염소, 브롬, 메틸 또는 에틸인 방법.
  8. 제 1항에 있어서, 1―〔2―(4―클로로페닐)―4―퀴놀리닐〕―N―에틸―4―피페리딘카복스아미드를 제조하는 방법.
  9. 제 1항에 있어서, 1―〔2―(4―클로로페닐)―6―플루오로―4―퀴놀리닐〕―4―피페리딘카복스아미드를 제조하는 방법.
  10. 제 1항에 있어서, 1―〔2―(4―클로로페닐)―4―퀴놀리닐〕―N―에틸―4―피페리딘카복스아미드를 제조하는 방법.
  11. 제 1항에 있어서, 1―〔2―(4―클로로페닐)―4―퀴놀리닐〕―4―피페리딘카복스아미드를 제조하는 방법.
  12. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850005110A 1984-07-18 1985-07-18 4-아미노-2-페닐퀴놀린의 제조방법 KR860001097A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US631971 1984-07-18
US06/631,971 US4560692A (en) 1984-07-18 1984-07-18 4-Piperidino-2-phenylquinolines

Publications (1)

Publication Number Publication Date
KR860001097A true KR860001097A (ko) 1986-02-22

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ID=24533539

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Application Number Title Priority Date Filing Date
KR1019850005110A KR860001097A (ko) 1984-07-18 1985-07-18 4-아미노-2-페닐퀴놀린의 제조방법

Country Status (18)

Country Link
US (1) US4560692A (ko)
EP (1) EP0168812A1 (ko)
JP (1) JPS6136283A (ko)
KR (1) KR860001097A (ko)
AU (1) AU4508085A (ko)
CS (1) CS252830B2 (ko)
DK (1) DK326085A (ko)
ES (2) ES8609302A1 (ko)
FI (1) FI852790L (ko)
GR (1) GR851761B (ko)
HU (1) HU194207B (ko)
IL (1) IL75825A0 (ko)
MC (1) MC1691A1 (ko)
NO (1) NO852854L (ko)
PH (1) PH21022A (ko)
PT (1) PT80824B (ko)
ZA (1) ZA854718B (ko)
ZW (1) ZW11785A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3800868A1 (de) * 1988-01-14 1989-07-27 Thomae Gmbh Dr K Mittel zur behandlung von bradycardien und bradyarrhythmien
US5304554A (en) * 1990-04-27 1994-04-19 Emory University 4-[(alkyl or dialkyl)amino]quinolines and their method of preparation
AU2879799A (en) 1998-02-26 1999-09-15 Neurogen Corporation 4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: gaba brain receptor ligands
AU2793199A (en) * 1998-02-26 1999-09-15 Neurogen Corporation 2-(het-)aryl-4-(cyclic amino substituted) heteroaryl fused pyridine derivatives,their preparation and their use as (ant-)agonists for gaba (a) brain receptors
US6297256B1 (en) * 1999-06-15 2001-10-02 Neurogen Corporation Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
US6440995B1 (en) 1999-10-01 2002-08-27 Hoffman-La Roche Inc. Quinolin-4-yl derivatives
US6339093B1 (en) * 1999-10-08 2002-01-15 Hoffmann-La Roche Inc. Isoquinoline derivatives
WO2001083456A1 (fr) 2000-04-27 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Derives d'heteroaryle condenses
US7825389B2 (en) 2007-12-04 2010-11-02 Tel Epion Inc. Method and apparatus for controlling a gas cluster ion beam formed from a gas mixture
BR112015023948A2 (pt) * 2013-03-18 2017-07-18 Genoscience Pharma composto de fórmula (i), composição farmacêutica, método para o tratamento e/ou prevenção de uma doença proliferativa e para a inibição ou a diferenciação do crescimento de uma célula tronco do câncer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1510009A (fr) * 1966-12-02 1968-01-19 Dérivés de l'amino-4 quinoléine
PT66682B (pt) * 1976-06-18 1978-11-15 Ind Biolog Francaise /(quinolyl-4)-propyl-1/-4 piperidines leur preparation et leur utilisation comme medicaments /(quinolyl-4)-propyl/-4 piperidines leur preparation et leur utilisation comme medicaments
FR2485014A1 (fr) * 1980-06-20 1981-12-24 Pharmindustrie Nouveaux derives de (quinolyl-2, -3 ou -4)-1 (piperidyl ou pyrrolidinyl-2 ou -3)-2 ou -3 ethanone ou propanone, procedes pour leur preparation, et leur utilisation comme medicaments
HU190796B (en) * 1981-06-12 1986-11-28 Roussel Uclaf,Fr Process for producing n-dihydrothiazolyl-3-quinoline-carboxamide derivatives

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ZA854718B (en) 1986-03-26
ES8705421A1 (es) 1987-05-01
IL75825A0 (en) 1985-11-29
DK326085A (da) 1986-01-19
ES545298A0 (es) 1986-09-01
HUT38333A (en) 1986-05-28
PT80824B (en) 1987-05-27
ZW11785A1 (en) 1986-02-12
CS527485A2 (en) 1987-03-12
FI852790L (fi) 1986-01-19
US4560692A (en) 1985-12-24
JPS6136283A (ja) 1986-02-20
FI852790A0 (fi) 1985-07-16
HU194207B (en) 1988-01-28
GR851761B (ko) 1985-11-26
ES552402A0 (es) 1987-05-01
ES8609302A1 (es) 1986-09-01
EP0168812A1 (de) 1986-01-22
PT80824A (en) 1985-08-01
MC1691A1 (fr) 1986-07-18
PH21022A (en) 1987-06-30
NO852854L (no) 1986-01-20
CS252830B2 (en) 1987-10-15
DK326085D0 (da) 1985-07-17
AU4508085A (en) 1986-01-23

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