KR840005447A - 밀베마이신 d 유도체의 제조방법 - Google Patents
밀베마이신 d 유도체의 제조방법 Download PDFInfo
- Publication number
- KR840005447A KR840005447A KR1019830003387A KR830003387A KR840005447A KR 840005447 A KR840005447 A KR 840005447A KR 1019830003387 A KR1019830003387 A KR 1019830003387A KR 830003387 A KR830003387 A KR 830003387A KR 840005447 A KR840005447 A KR 840005447A
- Authority
- KR
- South Korea
- Prior art keywords
- acid
- compound
- general formula
- reactive derivative
- group
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 하기 식(I)의 화합물을 일반식 HOOC-R-COOH의 이염기산 또는 상기 산의 반응성 유도체와 반응시킴을 특징으로 하는 일반식(II)의 화합물의 제조방법.
-
- [식 중, R은 1∼4 탄소원자를 갖는 직쇄 알킬렌기, 비닐렌기 또는 일반식(식중, X는 수소원자 또는 1∼6 탄소원자를 갖는 알킬기이다)의 기를 나타낸다.]
- 제1항에 있어서, 산의 반응성 유도체가 산할라이드, 모노카르복실산과의 혼합 무수물 또는 내부 무수물인 방법.
- 제1항에 있어서, 산의 반응성 유도체가 일반식의 화합물 또는 일반식 Y-CO-R-COOH(식 중, Y는 히드록시기, 할로겐원자 또는 C2∼C5S/SB> 알킬 카르보닐기이다)의 화합물인 방법.
- 제1항에 있어서, 반응기 염기 및 불활성 용매의 존재하에 수행되는 방법.
- 제1항에 있어서, 반응이 -10℃∼+50℃의 온도에서 수행되는 방법.
- 제1항에 있어서, 반응성 유도체는 R이 에틸렌인 내부 무수물이며, 반응이 4-디메틸아미노피리딘 및 피리딘의 존재하에 수행되는 방법.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP128472 | 1982-07-23 | ||
JP57128472A JPS5920285A (ja) | 1982-07-23 | 1982-07-23 | ミルベマイシンdの5−二塩基酸エステル誘導体及びその塩 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840005447A true KR840005447A (ko) | 1984-11-12 |
KR900008698B1 KR900008698B1 (ko) | 1990-11-27 |
Family
ID=14985570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019830003387A KR900008698B1 (ko) | 1982-07-23 | 1983-07-22 | 밀베마이신 d 유도체의 제조방법 |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0102721B1 (ko) |
JP (1) | JPS5920285A (ko) |
KR (1) | KR900008698B1 (ko) |
AU (1) | AU559048B2 (ko) |
BR (1) | BR8303940A (ko) |
CA (1) | CA1202967A (ko) |
DE (1) | DE3361293D1 (ko) |
DK (1) | DK337783A (ko) |
ES (1) | ES524399A0 (ko) |
IE (1) | IE55552B1 (ko) |
IL (1) | IL69295A0 (ko) |
NZ (1) | NZ205003A (ko) |
SE (1) | SE8304067L (ko) |
ZA (1) | ZA835354B (ko) |
ZW (1) | ZW16583A1 (ko) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60126289A (ja) * | 1983-11-14 | 1985-07-05 | Sankyo Co Ltd | ミルベマイシン類の5−カ−ボネ−ト誘導体 |
DK165119C (da) * | 1984-06-05 | 1993-03-01 | American Cyanamid Co | Antibiotiske forbindelser betegnet ll-f28249alfa, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa, my og ny og pharmaceutisk or pharmakologisk acceptable salte deraf samt fremgangsmaade til deres fremstilling |
US5198464A (en) * | 1984-06-05 | 1993-03-30 | American Cyanamid Company | Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents |
US5317030A (en) * | 1984-06-05 | 1994-05-31 | American Cyanamid Company | Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents |
US5169956A (en) * | 1984-06-05 | 1992-12-08 | American Cyanamid Company | Macrolide antibiotic compounds |
US4579864A (en) * | 1984-06-11 | 1986-04-01 | Merck & Co., Inc. | Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives |
GB2168345B (en) * | 1984-12-14 | 1988-05-25 | Ciba Geigy Ag | Pesticidal 13b-substituted milbemycin derivatives |
US4778809A (en) * | 1985-08-23 | 1988-10-18 | Ciba-Geigy Corporation | 5-esters of milbemycins for controlling parasitic pests |
US4916153A (en) * | 1986-03-12 | 1990-04-10 | American Cyanamid Company | Macrolid compounds |
GB8803836D0 (en) * | 1988-02-18 | 1988-03-16 | Glaxo Group Ltd | Compositions |
US5428034A (en) * | 1988-09-02 | 1995-06-27 | Sankyo Co., Ltd. | Milbemycin derivatives, their preparation and their use |
JP2622197B2 (ja) * | 1990-03-01 | 1997-06-18 | 三共株式会社 | 13−エーテル置換ミルベマイシン誘導体 |
US6495591B1 (en) | 1997-10-02 | 2002-12-17 | Essential Therapeutics, Inc. | Fungal efflux pump inhibitors |
KR100711931B1 (ko) | 2000-04-27 | 2007-05-02 | 상꾜 라이프테크 가부시키가이샤 | 13-치환 밀베마이신 유도체, 그의 제조 및 곤충 및 다른해충에 대한 그의 용도 |
WO2012028556A1 (en) | 2010-08-31 | 2012-03-08 | Bayer Animal Health Gmbh | Macrocyclic lactones and their use and their combinations with other active substances |
DE102010064245A1 (de) | 2010-12-28 | 2012-06-28 | Bayer Animal Health Gmbh | Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5632481A (en) * | 1979-08-23 | 1981-04-01 | Sankyo Co Ltd | Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent |
NZ201681A (en) * | 1981-09-03 | 1985-11-08 | Merck & Co Inc | Avermectin derivatives and parasiticidal compositions |
-
1982
- 1982-07-23 JP JP57128472A patent/JPS5920285A/ja active Pending
-
1983
- 1983-07-18 DE DE8383304145T patent/DE3361293D1/de not_active Expired
- 1983-07-18 EP EP83304145A patent/EP0102721B1/en not_active Expired
- 1983-07-19 CA CA000432712A patent/CA1202967A/en not_active Expired
- 1983-07-20 SE SE8304067A patent/SE8304067L/xx not_active Application Discontinuation
- 1983-07-21 IE IE1709/83A patent/IE55552B1/en not_active IP Right Cessation
- 1983-07-21 ZW ZW165/83A patent/ZW16583A1/xx unknown
- 1983-07-21 IL IL69295A patent/IL69295A0/xx unknown
- 1983-07-21 AU AU17168/83A patent/AU559048B2/en not_active Ceased
- 1983-07-22 DK DK337783A patent/DK337783A/da not_active Application Discontinuation
- 1983-07-22 ES ES524399A patent/ES524399A0/es active Granted
- 1983-07-22 NZ NZ205003A patent/NZ205003A/en unknown
- 1983-07-22 BR BR8303940A patent/BR8303940A/pt unknown
- 1983-07-22 KR KR1019830003387A patent/KR900008698B1/ko not_active IP Right Cessation
- 1983-07-22 ZA ZA835354A patent/ZA835354B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ZA835354B (en) | 1984-04-25 |
EP0102721B1 (en) | 1985-11-21 |
ES8502126A1 (es) | 1984-12-16 |
DK337783A (da) | 1984-01-24 |
ZW16583A1 (en) | 1984-02-15 |
IL69295A0 (en) | 1983-11-30 |
SE8304067L (sv) | 1984-01-24 |
NZ205003A (en) | 1986-06-11 |
JPS5920285A (ja) | 1984-02-01 |
AU559048B2 (en) | 1987-02-19 |
IE55552B1 (en) | 1990-10-24 |
DK337783D0 (da) | 1983-07-22 |
DE3361293D1 (en) | 1986-01-02 |
SE8304067D0 (sv) | 1983-07-20 |
IE831709L (en) | 1984-01-23 |
ES524399A0 (es) | 1984-12-16 |
AU1716883A (en) | 1984-01-26 |
CA1202967A (en) | 1986-04-08 |
EP0102721A1 (en) | 1984-03-14 |
KR900008698B1 (ko) | 1990-11-27 |
BR8303940A (pt) | 1984-02-28 |
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