KR850005845A - 7-아미노-3-치환된-메틸-3-세펨-4-카복실산 및 그의 저급 알킬실릴 유도체의 제조방법 - Google Patents

7-아미노-3-치환된-메틸-3-세펨-4-카복실산 및 그의 저급 알킬실릴 유도체의 제조방법 Download PDF

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Publication number
KR850005845A
KR850005845A KR1019850000823A KR850000823A KR850005845A KR 850005845 A KR850005845 A KR 850005845A KR 1019850000823 A KR1019850000823 A KR 1019850000823A KR 850000823 A KR850000823 A KR 850000823A KR 850005845 A KR850005845 A KR 850005845A
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South Korea
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amino
formula
group
substituted
carboxylic acid
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KR1019850000823A
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KR920002869B1 (ko
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다다오 시바누마 (외 6)
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모리오까 시게오
야마노우찌 세이야꾸 가부시기 가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음

Description

7-아미노-3-치환된-메틸-3-세펨-4-카복실산 및 그의 저급 알킬실릴 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 일반식(Ⅲ)의 7-아미노-3-할로게노메틸-3-세펨-4-카복실산을 일산식(Ⅲ1) 또는(Ⅲ2)의 (트리-저급알킬실릴)트리플루오로아세트 아미드 및 일반식(Ⅳ)의 피라딘 화합물과 반응시킨 다음 생성된 일반식(Ⅰ1)의 화합물의 보호그룹(즉, 트리저급알킬실릴그룹)을 제거함을 특징으로 하여, 일반식(Ⅰ2)의 7-아미노-3-치환된-메틸-3-세펨-4-카복실산 또는 카복실레이트를 제조하는 방법.
    상기식에서, R1은 저급알킬 그룹이고,
    A는또는
    이며,
    R2는 수소원자 또는 아미노 그룹이고, n은 정수 1 또는 2이고,는 음이온이고, X는 할로겐원자이다.
  2. 일반식(Ⅱ)의 7-아미노-3-할로게노메틸-3-세펨-4-카복실산을 일반식(Ⅲ1) 또는 (Ⅲ2)의 (트리-저급알킬실릴)트리플루오로아세트아미드 및 일반식(Ⅳ)의 피리딘 화합물과 반응시킴을 특징으로하여, 일반식(Ⅰ)의 트리-저급알킬실릴 유도체를 제조하는 방법.
    상기식에서,
    이며,
    R2는 수소원자 또는 아미노 그룹이고, n은 정수 1또는 2이고, ,는 음이온이고, R1은 저급알킬 그룹이고, X는 할로겐 원자이다.
  3. 일반식(Ⅰ1)의 트리-저급알킬실릴 유도체로부터 보호그룹(즉, 트리-저급알킬실릴그룹)을 제거함을 특징으로 하여, 일반식(Ⅰ2)의 7-아미노-3-치환된-메틸-3-세펨-4-카복실산을 제조하는 방법.
    (여기에서, R2는 수소원자 또는 아미노 그룹이고, n은 정수 1또는 2이다)이고,는 음이온이고, R1은 저급 알킬그룹이다.
  4. 제1,2 또는 3항에 있어서, R1이 메틸그룹인 방법.
  5. 제 1,2 또는 3항에 있어서, X가 요오드원자이고, Y가 요오드 원자인 방법.
  6. 제1,2 또는 3항에 있어서, Y가 무기 음이온인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850000823A 1984-02-10 1985-02-09 7-아미노-3-치환된-메틸-3-세펨-4-카복실산 및 그의 저급 알킬실릴 유도체의 제조방법 KR920002869B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP24110 1984-02-10
JP59024110A JPS60169486A (ja) 1984-02-10 1984-02-10 ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
JP24110/84 1984-02-10

Publications (2)

Publication Number Publication Date
KR850005845A true KR850005845A (ko) 1985-09-26
KR920002869B1 KR920002869B1 (ko) 1992-04-06

Family

ID=12129194

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KR1019850000823A KR920002869B1 (ko) 1984-02-10 1985-02-09 7-아미노-3-치환된-메틸-3-세펨-4-카복실산 및 그의 저급 알킬실릴 유도체의 제조방법

Country Status (5)

Country Link
US (2) US4699980A (ko)
EP (1) EP0154417A3 (ko)
JP (1) JPS60169486A (ko)
KR (1) KR920002869B1 (ko)
ES (2) ES8700861A1 (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60169486A (ja) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
WO1986003204A1 (en) * 1984-11-23 1986-06-05 Biochemie Gesellschaft M.B.H. New process for procuding cephalosporine derivatives
US4749522A (en) * 1985-10-31 1988-06-07 Angio-Medical Corporation Supercritical fluid extraction of animal derived materials
US5231170A (en) * 1986-08-27 1993-07-27 Paul Averback Antibodies to dense microspheres
EP0300546B1 (en) * 1987-07-10 1995-08-09 Gist-Brocades N.V. Process for the preparation of cephem compounds and cephalosporin derivatives
AT395854B (de) * 1991-05-24 1993-03-25 Biochemie Gmbh Neues verfahren zur herstellung von 7-amino-3azidomethyl-3-cephem-4-carbonsaeure und deren derivate
EP2753326A4 (en) 2011-09-09 2015-04-15 Cubist Pharm Inc METHOD FOR THE TREATMENT OF INTRAPULMONARY INFECTIONS
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
CN110279698B (zh) 2013-03-15 2022-10-28 默沙东有限责任公司 头孢特咯瓒抗生素组合物
US20140274993A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane-tazobactam pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5653557B2 (ko) * 1973-10-15 1981-12-19
GB1532682A (en) * 1976-04-27 1978-11-22 Bristol Myers Co Process for the preparation of cephadroxil
GB2069482B (en) * 1980-02-14 1984-04-04 Gist Brocades Nv Process for the preparation of 3'-bromosubstituted deacetoxycephalosporanic acid sulphoxide derivatives
DE3175156D1 (en) * 1980-08-29 1986-09-25 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"
GB2125807B (en) * 1982-05-26 1986-01-08 Lilly Industries Ltd Preparation of penicillin and cephalosporin compounds and novel intermediates useful therein
DE3232391A1 (de) * 1982-08-31 1984-03-01 Bayer Ag, 5090 Leverkusen Polycarbonate mit konjugierte doppelbindungen enthaltenden endgruppen, gegebenenfalls im gemisch mit bekannten aromatischen polycarbonaten, ihre herstellung und ihre verwendung
DE3247613A1 (de) * 1982-12-23 1984-07-05 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3248281A1 (de) * 1982-12-28 1984-06-28 Hoechst Ag, 6230 Frankfurt Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
DE3316796A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
DE3316798A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
US4540779A (en) * 1983-06-20 1985-09-10 Eli Lilly And Company Crystalline 7-(R)-amino-3-(1'pyridiniummethyl)-ceph-3-em-4-carboxylate monohydrochloride monohydrate compound
JPS60169486A (ja) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
US4665168A (en) * 1986-04-14 1987-05-12 Eli Lilly And Company Cephalosporin intermediate

Also Published As

Publication number Publication date
US4699980A (en) 1987-10-13
US4845211A (en) 1989-07-04
ES8700861A1 (es) 1986-11-16
ES8800241A1 (es) 1987-11-01
EP0154417A2 (en) 1985-09-11
ES554060A0 (es) 1987-11-01
ES540200A0 (es) 1986-11-16
KR920002869B1 (ko) 1992-04-06
EP0154417A3 (en) 1986-06-11
JPS60169486A (ja) 1985-09-02

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