KR830004311A - 페니실린 화합물의 제조방법 - Google Patents

페니실린 화합물의 제조방법 Download PDF

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Publication number
KR830004311A
KR830004311A KR1019800003809A KR800003809A KR830004311A KR 830004311 A KR830004311 A KR 830004311A KR 1019800003809 A KR1019800003809 A KR 1019800003809A KR 800003809 A KR800003809 A KR 800003809A KR 830004311 A KR830004311 A KR 830004311A
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South Korea
Prior art keywords
hydrogen
group
hydroxy
formula
structural formula
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KR1019800003809A
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English (en)
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KR840000799B1 (ko
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마까베 오사무
무라이 야수시
오고노기 투네오
오노데라 마사히로
요시다 다까시
후까쮸 순조
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나까가와 규우
메이지 세이까 가부시끼 가이샤
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Priority to KR1019800003809A priority Critical patent/KR840000799B1/ko
Publication of KR830004311A publication Critical patent/KR830004311A/ko
Application granted granted Critical
Publication of KR840000799B1 publication Critical patent/KR840000799B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/70—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with hetero rings as additional substituents on the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

페니실린 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 구조식(A)로 표시되는 아목실린이나 기능그룹이 보호된 아목실린을 구조식(Ⅱ)의 카복실산이나 이들의 반응성 유도체 또는 R1,R2및 또는 R3가 하이드록시를 나타낼 때는 이 카복실산의 하이드록시 보호유도체나 그 반응성 유도체와 반응시킴을 특징으로 하여 구조식(Ⅲ)으로 표시되는 페니실린 화합물 및 약학적으로 무독한 이들의 염을 제조하는 방법.
    상기 구조식(Ⅲ)에서
    R1,R2및 R3는 수소, 저급알킬그룹, 할로겐원자, 저급알콕시그룹, 하이드록시그룹, 치환되거나 치환되지 않은 페닐알콕시그룹(R1,R2및 R3는 동시에 수소일 수는 없다)이며;
    R4는 수소나 저급알킬그룹이다.
    상기 구조식(Ⅱ)에서
    R1,R2,R3와 R4와는 전술한 바와 같다.
  2. 6-아미노페니실란산이나 기능그룹이 보호된 이들의 유도체를 다음 구조식(Ⅳ)로 표시되는 화합물이나 이들의 반응성 유도체 또는 R1,R2,R3및 또는 R5가 하이드록시를 의미할 때는 하이드록시가 보호된 유도체나 그 반응성 유도체와 반응시킴을 특징으로 하여 다음 구조식(I)의 페니실린 화합물을 제조하는 방법.
    상기 구조식(I)에서
    R1,R2와 R3는 수소, 저급알킬그룹, 할로겐원자, 저급알콕시, 하이드록시그룹, 치환되거나 비치환된 알콕시그룹이며; R4는 수소나 저급알콕시그룹, R5는 수소나 하이드록시그룹(R1,R2및 R3가 동시에 수소일 수는 없다)을 나타낸다.
    상기 구조식(Ⅳ)에서 R1,R2,R3,R4와 R5는 전술한 바와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800003809A 1980-10-02 1980-10-02 페니실린 화합물의 제조방법 KR840000799B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019800003809A KR840000799B1 (ko) 1980-10-02 1980-10-02 페니실린 화합물의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019800003809A KR840000799B1 (ko) 1980-10-02 1980-10-02 페니실린 화합물의 제조방법

Publications (2)

Publication Number Publication Date
KR830004311A true KR830004311A (ko) 1983-07-09
KR840000799B1 KR840000799B1 (ko) 1984-06-12

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KR1019800003809A KR840000799B1 (ko) 1980-10-02 1980-10-02 페니실린 화합물의 제조방법

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KR840000799B1 (ko) 1984-06-12

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