KR850007800A - 세팔로스포린 유도체의 에스테르 제조방법 - Google Patents
세팔로스포린 유도체의 에스테르 제조방법 Download PDFInfo
- Publication number
- KR850007800A KR850007800A KR1019850000263A KR850000263A KR850007800A KR 850007800 A KR850007800 A KR 850007800A KR 1019850000263 A KR1019850000263 A KR 1019850000263A KR 850000263 A KR850000263 A KR 850000263A KR 850007800 A KR850007800 A KR 850007800A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- alkyl
- compound
- group
- cephalosporin derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- 7β-〔2-(2-아미노티아졸-4-일)-(Z)-2-메톡스이미노아세트아미도〕-3-〔(1,2,3-타아디아졸-5-일)-티오메틸〕세프-3-엠-4-카르복실산을 산수용체 존재하에 하기 구조식(а)의 알킬화제와 반응시키는 단계로 구성되는, 하기 구조식(Ⅰ)화합물의 제조방법.상기식에서, R1은 수소 및 C1-C6알킬로 이루어지는 군에서 선택되고, R2는 C1-C6알킬, 아릴, 아다만틸 및 -OR3(R3는 C1-C6알킬)로 이루어지는 군에서 선택된다.
- (가) 하기 구조식(b) 화합물을 산수용체 존재하에 구조식(a)의 알킬화제와 반응시켜 구조식(c)화합물을 얻고, (나) 단계(가)의 생성물을 디시클로헥실카르보디이미드와 Ⅰ-하이드록시벤조트리아졸의 존재하에 구조식(d) 화합물과 반응시키는 단계들로 구성되는, 구조식(Ⅰ)화합물의 제조방법.상기식에서 R1은 수소 및 C1-C6알킬로 이루어지는 군에서 선택되고, R2는 C1-C6알킬, 아릴, 아다만틸 및 -OR3(R3는 C1-C6알킬)로 이루어지는 군에서 선택되며, 구조식(b)와 (d)의 아민기는 보호될 수 있다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US595844 | 1984-04-02 | ||
US06/595,844 US4914091A (en) | 1984-04-02 | 1984-04-02 | Esters of cephalosporin derivitives |
US595,844 | 1984-04-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR850007800A true KR850007800A (ko) | 1985-12-09 |
KR870001007B1 KR870001007B1 (ko) | 1987-05-18 |
Family
ID=24384908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850000263A KR870001007B1 (ko) | 1984-04-02 | 1985-01-17 | 세팔로스포린 유도체의 에스테르 제조방법 |
Country Status (15)
Country | Link |
---|---|
US (1) | US4914091A (ko) |
EP (1) | EP0157000A3 (ko) |
JP (1) | JPS60209589A (ko) |
KR (1) | KR870001007B1 (ko) |
AU (1) | AU571042B2 (ko) |
DK (1) | DK626984A (ko) |
ES (2) | ES8606873A1 (ko) |
FI (1) | FI851306L (ko) |
HU (1) | HU194252B (ko) |
IL (1) | IL73918A0 (ko) |
NO (1) | NO851336L (ko) |
NZ (1) | NZ210761A (ko) |
PH (1) | PH20664A (ko) |
PT (1) | PT80180B (ko) |
ZA (1) | ZA85240B (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0252473A3 (en) * | 1986-07-08 | 1989-07-05 | American Cyanamid Company | 7 beta-(substituted) amino-3-substituted cephalosporanic acids and esters |
SG10201600910YA (en) * | 2009-08-10 | 2016-03-30 | Bhi Ltd Partnership | Methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid |
EP2968274B1 (en) * | 2013-03-15 | 2019-10-16 | Kala Pharmaceuticals, Inc. | Meropenem derivatives and uses thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1425933A (en) * | 1972-03-13 | 1976-02-25 | Astra Laekemedel Ab | Cephalosporins |
DE2758000A1 (de) * | 1977-12-24 | 1979-07-05 | Hoechst Ag | Verfahren zur herstellung von penicillinen und cephalosporinen |
NL8003186A (nl) * | 1979-06-01 | 1980-12-03 | Sankyo Co | Cefalosporine-verbindingen die geschikt zijn voor orale toediening. |
US4399132A (en) * | 1980-08-11 | 1983-08-16 | American Cyanamid Company | 7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-acetamido]-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C1 -C6 alkyl derivatives thereof |
ES507942A0 (es) * | 1980-12-15 | 1983-02-01 | Fujisawa Pharmaceutical Co | Un procedimiento para preparar derivados del acido 7-acilaminocefalosporanico . |
JPS57163386A (en) * | 1981-08-13 | 1982-10-07 | Takeda Chem Ind Ltd | Cephalosporin derivative and its production |
JPS59225191A (ja) * | 1983-06-02 | 1984-12-18 | Takeda Chem Ind Ltd | 経口用セフアロスポリン誘導体 |
CA1215354A (en) * | 1983-06-02 | 1986-12-16 | Akio Miyake | Cephalosporin esters, their production and use |
-
1984
- 1984-04-02 US US06/595,844 patent/US4914091A/en not_active Expired - Lifetime
- 1984-09-27 JP JP59200689A patent/JPS60209589A/ja active Pending
- 1984-12-20 EP EP84116013A patent/EP0157000A3/en not_active Withdrawn
- 1984-12-21 DK DK626984A patent/DK626984A/da not_active Application Discontinuation
- 1984-12-21 AU AU37021/84A patent/AU571042B2/en not_active Ceased
- 1984-12-23 IL IL73918A patent/IL73918A0/xx unknown
-
1985
- 1985-01-04 ES ES539367A patent/ES8606873A1/es not_active Expired
- 1985-01-04 NZ NZ210761A patent/NZ210761A/xx unknown
- 1985-01-10 ZA ZA85240A patent/ZA85240B/xx unknown
- 1985-01-10 HU HU8578A patent/HU194252B/hu unknown
- 1985-01-17 KR KR1019850000263A patent/KR870001007B1/ko not_active IP Right Cessation
- 1985-03-27 PH PH32057A patent/PH20664A/en unknown
- 1985-03-28 PT PT80180A patent/PT80180B/pt not_active IP Right Cessation
- 1985-04-01 NO NO851336A patent/NO851336L/no unknown
- 1985-04-01 FI FI851306A patent/FI851306L/fi not_active Application Discontinuation
- 1985-11-26 ES ES549294A patent/ES8606359A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES539367A0 (es) | 1986-05-16 |
PH20664A (en) | 1987-03-23 |
US4914091A (en) | 1990-04-03 |
HUT37436A (en) | 1985-12-28 |
FI851306A0 (fi) | 1985-04-01 |
DK626984D0 (da) | 1984-12-21 |
KR870001007B1 (ko) | 1987-05-18 |
AU571042B2 (en) | 1988-03-31 |
IL73918A0 (en) | 1985-03-31 |
NZ210761A (en) | 1988-08-30 |
PT80180A (en) | 1985-04-01 |
EP0157000A2 (en) | 1985-10-09 |
FI851306L (fi) | 1985-10-03 |
AU3702184A (en) | 1985-10-10 |
EP0157000A3 (en) | 1986-10-22 |
ES549294A0 (es) | 1986-05-01 |
ES8606359A1 (es) | 1986-05-01 |
JPS60209589A (ja) | 1985-10-22 |
HU194252B (en) | 1988-01-28 |
DK626984A (da) | 1985-10-03 |
ZA85240B (en) | 1985-09-25 |
PT80180B (en) | 1987-02-06 |
ES8606873A1 (es) | 1986-05-16 |
NO851336L (no) | 1985-10-03 |
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G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
LAPS | Lapse due to unpaid annual fee |