ES8606873A1 - Procedimiento para preparar esteres de cefalosporinas - Google Patents

Procedimiento para preparar esteres de cefalosporinas

Info

Publication number
ES8606873A1
ES8606873A1 ES539367A ES539367A ES8606873A1 ES 8606873 A1 ES8606873 A1 ES 8606873A1 ES 539367 A ES539367 A ES 539367A ES 539367 A ES539367 A ES 539367A ES 8606873 A1 ES8606873 A1 ES 8606873A1
Authority
ES
Spain
Prior art keywords
ester
cephalosporin derivatives
cephalosporin
derivatives
prodrugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539367A
Other languages
English (en)
Other versions
ES539367A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES539367A0 publication Critical patent/ES539367A0/es
Publication of ES8606873A1 publication Critical patent/ES8606873A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ESTERES DE CEFALOSPORINA, DE FORMULA (I), EN LA QUE R1 REPRESENTA HIDROGENO O ALQUILO C1-6; Y R2 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. COMPRENDE LA REACCION DE ALQUILACION DEL ACIDO 7B-2-(2-AMINO-TIAZOL-4-IL)-(Z)-2-METOXIMINOACETAMIDO-3-(1,2,3-TIADIAZOL-5-IL)-TIADIAZOL-5-IL-TIOMETILCEF-3-EM-4-CARBPXILICO, POR TRATAMIENTO CON UN AGENTE ALQUILANTE DE FORMULA (II), EN LA QUE R1 Y R2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), EN PRESENCIA DE UN ACEPTOR DE ACIDO, TAL COMO UNA AMINA TERCIARIA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIAL.
ES539367A 1984-04-02 1985-01-04 Procedimiento para preparar esteres de cefalosporinas Expired ES8606873A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/595,844 US4914091A (en) 1984-04-02 1984-04-02 Esters of cephalosporin derivitives

Publications (2)

Publication Number Publication Date
ES539367A0 ES539367A0 (es) 1986-05-16
ES8606873A1 true ES8606873A1 (es) 1986-05-16

Family

ID=24384908

Family Applications (2)

Application Number Title Priority Date Filing Date
ES539367A Expired ES8606873A1 (es) 1984-04-02 1985-01-04 Procedimiento para preparar esteres de cefalosporinas
ES549294A Expired ES8606359A1 (es) 1984-04-02 1985-11-26 Procedimiento para preparar esteres de cefalosporinas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES549294A Expired ES8606359A1 (es) 1984-04-02 1985-11-26 Procedimiento para preparar esteres de cefalosporinas

Country Status (15)

Country Link
US (1) US4914091A (es)
EP (1) EP0157000A3 (es)
JP (1) JPS60209589A (es)
KR (1) KR870001007B1 (es)
AU (1) AU571042B2 (es)
DK (1) DK626984A (es)
ES (2) ES8606873A1 (es)
FI (1) FI851306L (es)
HU (1) HU194252B (es)
IL (1) IL73918A0 (es)
NO (1) NO851336L (es)
NZ (1) NZ210761A (es)
PH (1) PH20664A (es)
PT (1) PT80180B (es)
ZA (1) ZA85240B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252473A3 (en) * 1986-07-08 1989-07-05 American Cyanamid Company 7 beta-(substituted) amino-3-substituted cephalosporanic acids and esters
NZ598085A (en) * 2009-08-10 2014-02-28 Bhi Ltd Partnership Methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid
BR112015023621A8 (pt) 2013-03-15 2018-01-23 Kala Pharmaceuticals Inc derivados de meropenem e suas utilizações

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1425933A (en) * 1972-03-13 1976-02-25 Astra Laekemedel Ab Cephalosporins
DE2758000A1 (de) * 1977-12-24 1979-07-05 Hoechst Ag Verfahren zur herstellung von penicillinen und cephalosporinen
IT8067851A0 (it) * 1979-06-01 1980-05-30 Sankyo Co Derivati di cefalosporina sommini strabili per via orale e procedimento per la loro preparazione
US4399132A (en) * 1980-08-11 1983-08-16 American Cyanamid Company 7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-acetamido]-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C1 -C6 alkyl derivatives thereof
IT1142096B (it) * 1980-12-15 1986-10-08 Fujisawa Pharmaceutical Co Derivati dell'acido 7-acilammino cefalosporanico e procedimenti per la loro preparazione
JPS57163386A (en) * 1981-08-13 1982-10-07 Takeda Chem Ind Ltd Cephalosporin derivative and its production
JPS59225191A (ja) * 1983-06-02 1984-12-18 Takeda Chem Ind Ltd 経口用セフアロスポリン誘導体
CA1215354A (en) * 1983-06-02 1986-12-16 Akio Miyake Cephalosporin esters, their production and use

Also Published As

Publication number Publication date
ES539367A0 (es) 1986-05-16
JPS60209589A (ja) 1985-10-22
KR850007800A (ko) 1985-12-09
FI851306L (fi) 1985-10-03
PT80180A (en) 1985-04-01
ZA85240B (en) 1985-09-25
FI851306A0 (fi) 1985-04-01
NZ210761A (en) 1988-08-30
EP0157000A2 (en) 1985-10-09
IL73918A0 (en) 1985-03-31
US4914091A (en) 1990-04-03
HUT37436A (en) 1985-12-28
DK626984A (da) 1985-10-03
ES549294A0 (es) 1986-05-01
AU3702184A (en) 1985-10-10
NO851336L (no) 1985-10-03
EP0157000A3 (en) 1986-10-22
PT80180B (en) 1987-02-06
DK626984D0 (da) 1984-12-21
HU194252B (en) 1988-01-28
PH20664A (en) 1987-03-23
ES8606359A1 (es) 1986-05-01
KR870001007B1 (ko) 1987-05-18
AU571042B2 (en) 1988-03-31

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