KR830001292A - 3-엑소메틸렌세팜 설폭사이드류의 제법 - Google Patents
3-엑소메틸렌세팜 설폭사이드류의 제법 Download PDFInfo
- Publication number
- KR830001292A KR830001292A KR1019790003526A KR790003526A KR830001292A KR 830001292 A KR830001292 A KR 830001292A KR 1019790003526 A KR1019790003526 A KR 1019790003526A KR 790003526 A KR790003526 A KR 790003526A KR 830001292 A KR830001292 A KR 830001292A
- Authority
- KR
- South Korea
- Prior art keywords
- structural formula
- alkyl
- cepam
- exomethylene
- following
- Prior art date
Links
- 150000003462 sulfoxides Chemical class 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 1
- 125000006244 carboxylic acid protecting group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- -1 oxo compound Chemical class 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/08—Preparation by forming the ring or condensed ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Cephalosporin Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 다음 구조식(2)를 갖는 3-엑소메틸렌세팜 설포사이드 에스테르를 제조하는 방법.상기 구조식에서 R은 카복실산 잔기이고 R1은 카복실산 보호그룹이고 다음 단계의 방법을 포함한다.(a) 불활성 유기용매 중에서 무수의 조건하에서 다음 구조식 1을 갖는 2-클로로 설피닐아제티딘-4-은과다음의 원자단을 갖는 옥소화합물을 존재하에서 스타닉크롤라이드와 반응 시키는 방법.상기 구조식에서 R2는 각각 C1-C4알킬, R2'는 C1-C4알킬 C5-C6-사이클로알킬, 페닐이나 C1-C4알킬로 치환된 페닐, C1-C4알콕시 혹은 할로겐이고 Z은 -(-CH2-)-m, -CH2-CH2-O-CH2-CH2혹은 -CH2-O-CH2-CH2-CH2이고 m은 4혹은 5이고 Z1는여기에서 R2 0는 각각 수소 혹은 C1-C4알킬이고 n2은 3-6이다.(b) 콜플렉스를 분리하고 분해하여 구조식(2)의 화합물을 생성시키는 방법.※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/960,346 US4190724A (en) | 1978-11-13 | 1978-11-13 | Process for 3-exomethylenecepham sulfoxides |
| US960346 | 1978-11-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830001292A true KR830001292A (ko) | 1983-04-30 |
| KR830001591B1 KR830001591B1 (ko) | 1983-08-16 |
Family
ID=25503071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019790003526A KR830001591B1 (ko) | 1978-11-13 | 1979-10-13 | 3-엑소 메틸렌세팜 설폭사이드의 제조방법 |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US4190724A (ko) |
| EP (1) | EP0011369B1 (ko) |
| JP (1) | JPS5566590A (ko) |
| KR (1) | KR830001591B1 (ko) |
| AR (1) | AR225421A1 (ko) |
| AT (1) | ATA663779A (ko) |
| AU (1) | AU5147779A (ko) |
| BE (1) | BE879210A (ko) |
| BG (1) | BG30628A3 (ko) |
| CA (1) | CA1150240A (ko) |
| CH (1) | CH640537A5 (ko) |
| CS (1) | CS209824B2 (ko) |
| DD (1) | DD146457A5 (ko) |
| DE (1) | DE2962353D1 (ko) |
| DK (1) | DK431479A (ko) |
| ES (1) | ES484917A0 (ko) |
| FI (1) | FI793094A (ko) |
| FR (1) | FR2440952A1 (ko) |
| GB (1) | GB2034702B (ko) |
| GR (1) | GR73094B (ko) |
| HU (1) | HU180745B (ko) |
| IE (1) | IE48964B1 (ko) |
| IL (1) | IL58406A (ko) |
| IS (1) | IS1041B6 (ko) |
| LU (1) | LU81769A1 (ko) |
| MA (1) | MA18605A1 (ko) |
| MW (1) | MW2979A1 (ko) |
| NO (1) | NO793271L (ko) |
| OA (1) | OA06355A (ko) |
| PL (1) | PL117584B1 (ko) |
| PT (1) | PT70263A (ko) |
| ZA (1) | ZA795242B (ko) |
| ZM (1) | ZM8379A1 (ko) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5832884A (ja) * | 1981-08-20 | 1983-02-25 | Otsuka Chem Co Ltd | ３−エキソメチレンセフアム誘導体の製造方法 |
| FI103048B1 (fi) * | 1989-03-22 | 1999-04-15 | Dsm Nv | Menetelmä 3-eksometyleenikefaamisulfoksidijohdannaisten valmistamiseksi |
| US4950753A (en) * | 1989-05-17 | 1990-08-21 | Eli Lilly And Company | Process for 3-exomethylenecepham sulfoxide esters |
| US5126446A (en) * | 1991-01-04 | 1992-06-30 | Eli Lilly And Company | Process for 3-exomethylenecepham sulfoxide esters |
| US5350845A (en) * | 1992-04-08 | 1994-09-27 | Eli Lilly And Company | Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters |
| US5604222A (en) * | 1993-12-27 | 1997-02-18 | Lupin Laboratories, Ltd. | Method for the preparation of 2-chloro sulfinyl azetidinones |
| US5578721A (en) * | 1994-07-11 | 1996-11-26 | Lupin Laboratories Limited | Process for preparation of 3-exomethylene cepham sulfoxide esters |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3843682A (en) * | 1972-05-15 | 1974-10-22 | Lilly Co Eli | 2-chlorosulfinyl-3-imido-azetedin-4-ones |
| US4052387A (en) * | 1974-12-24 | 1977-10-04 | Eli Lilly And Company | Method of preparation of 3-methylenecephams |
| GR59922B (en) * | 1974-12-24 | 1978-03-20 | Lilly Co Eli | Process for preparing 3-methylene cepham |
| CA1069126A (en) * | 1974-12-24 | 1980-01-01 | Eli Lilly And Company | Sulfinyl halides and their preparation from penicillin sulfoxides |
| US4375397A (en) * | 1976-03-15 | 1983-03-01 | E. R. Squibb & Sons, Inc. | Process for preparing 3-methylene cephalosporins |
-
1978
- 1978-11-13 US US05/960,346 patent/US4190724A/en not_active Expired - Lifetime
-
1979
- 1979-10-02 PT PT70263A patent/PT70263A/pt unknown
- 1979-10-02 MA MA18805A patent/MA18605A1/fr unknown
- 1979-10-02 ZA ZA00795242A patent/ZA795242B/xx unknown
- 1979-10-04 FR FR7924712A patent/FR2440952A1/fr active Granted
- 1979-10-04 AU AU51477/79A patent/AU5147779A/en not_active Abandoned
- 1979-10-05 IL IL58406A patent/IL58406A/xx unknown
- 1979-10-05 FI FI793094A patent/FI793094A/fi not_active Application Discontinuation
- 1979-10-05 BE BE1/9551A patent/BE879210A/fr not_active IP Right Cessation
- 1979-10-05 MW MW29/79A patent/MW2979A1/xx unknown
- 1979-10-08 BG BG7945077A patent/BG30628A3/xx unknown
- 1979-10-08 GR GR60217A patent/GR73094B/el unknown
- 1979-10-09 EP EP79302151A patent/EP0011369B1/en not_active Expired
- 1979-10-09 DE DE7979302151T patent/DE2962353D1/de not_active Expired
- 1979-10-09 GB GB7935061A patent/GB2034702B/en not_active Expired
- 1979-10-09 ZM ZM83/79A patent/ZM8379A1/xx unknown
- 1979-10-10 AR AR278436A patent/AR225421A1/es active
- 1979-10-10 LU LU81769A patent/LU81769A1/fr unknown
- 1979-10-10 ES ES484917A patent/ES484917A0/es active Granted
- 1979-10-10 CA CA000337271A patent/CA1150240A/en not_active Expired
- 1979-10-11 NO NO793271A patent/NO793271L/no unknown
- 1979-10-11 AT AT663779A patent/ATA663779A/de not_active Application Discontinuation
- 1979-10-12 JP JP13278479A patent/JPS5566590A/ja active Granted
- 1979-10-12 PL PL1979218930A patent/PL117584B1/pl unknown
- 1979-10-12 CH CH923979A patent/CH640537A5/fr not_active IP Right Cessation
- 1979-10-12 DK DK431479A patent/DK431479A/da unknown
- 1979-10-12 IE IE1941/79A patent/IE48964B1/en not_active IP Right Cessation
- 1979-10-12 HU HU79EI883A patent/HU180745B/hu unknown
- 1979-10-12 DD DD79216204A patent/DD146457A5/de unknown
- 1979-10-12 CS CS796949A patent/CS209824B2/cs unknown
- 1979-10-13 OA OA56915A patent/OA06355A/xx unknown
- 1979-10-13 KR KR1019790003526A patent/KR830001591B1/ko active
- 1979-10-15 IS IS2515A patent/IS1041B6/is unknown
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